The gut hormone glucagon-like peptide-1 produced in brain: Is this physiologically relevant?

Current Opinion in Pharmacology

Volumn 13, Issue 6, 2013, Pages 964-969

  Trapp, Stefan ^a   Richards, James E ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; PREPROGLUCAGON;

ARTICLE; BRAIN NERVE CELL; BRAIN REGION; BRAIN STEM; ENERGY BALANCE; FOOD INTAKE; FOREBRAIN; HEART RATE; HORMONE SYNTHESIS; HUMAN; IMMUNOCYTOCHEMISTRY; INSULIN RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SOLITARY TRACT NUCLEUS; THERMOREGULATION;

ANIMALS; BRAIN; GASTROINTESTINAL HORMONES; GASTROINTESTINAL TRACT; GLUCAGON-LIKE PEPTIDE 1; HUMANS; NEURONS;

EID: 84888205219     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2013.09.006     Document Type: Review

References (57)

1. A. De Silva The gut hormones PYY 3-36 and GLP-1 7-36 amide reduce food intake and modulate brain activity in appetite centers in humans Cell Metab 14 2011 700 706
2. K.G. Murphy, and S.R. Bloom Gut hormones and the regulation of energy homeostasis Nature 444 2006 854 859 (Pubitemid 46024992)
3. N. Vrang, and P.J. Larsen Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides Prog Neurobiol 92 2010 442 462
4. J.L. Lachey The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice Endocrinology 146 2005 458 462 (Pubitemid 40051771)
5. L. Huo Divergent leptin signaling in proglucagon neurons of the nucleus of the solitary tract in mice and rats Endocrinology 149 2008 492 497 (Pubitemid 351159324)
6. T.J. Kieffer, and J.F. Habener The glucagon-like peptides Endocr Rev 20 1999 876 913 (Pubitemid 30647076)
7. N. Vrang, and K. Grove The brainstem preproglucagon system in a non-human primate (Macaca mulatta) Brain Res 1397 2011 28 37
8. J.G. Barrera GLP-1 and energy balance: an integrated model of short-term and long-term control Nat Rev Endocrinol 7 2011 507 516
9. S. Trapp, and K. Hisadome Glucagon-like peptide 1 and the brain: central actions-central sources? Auton Neurosci 161 2011 14 19
10. S.L. Jin Distribution of glucagonlike peptide I (GLP-I), glucagon, and glicentin in the rat brain: an immunocytochemical study J Comp Neurol 271 1988 519 532
11. J.M. Conlon Glucagon-like polypeptides in canine brain Diabetes 28 1979 700 702 (Pubitemid 9226274)
12. I. Loren Gut-type glucagon immunoreactivity in nerves of the rat brain Histochemistry 61 1979 335 341 (Pubitemid 9243329)
13. D.J. Drucker, and S. Asa Glucagon gene expression in vertebrate brain J Biol Chem 263 1988 13475 13478
14. P.J. Larsen Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem Neuroscience 77 1997 257 270 (Pubitemid 27060323)
15. L. Rinaman Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamus Am J Physiol 277 1999 R582 R590
16. L. Rinaman Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energy expenditure Brain Res 1350 2010 18 34
17. I. Merchenthaler, M. Lane, and P. Shughrue Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system J Comp Neurol 403 1999 261 280 (Pubitemid 28566834)
18. N. Vrang Characterization of brainstem preproglucagon projections to the paraventricular and dorsomedial hypothalamic nuclei Brain Res 1149 2007 118 126 (Pubitemid 46671416)
19. A.M. Dossat Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake J Neurosci 31 2011 14453 14457
20. A.L. Alhadeff, L.E. Rupprecht, and M.R. Hayes GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake Endocrinology 153 2012 647 658
21. I.J. Llewellyn-Smith Preproglucagon (PPG) neurons innervate neurochemically identified autonomic neurons in the mouse brainstem Neuroscience 229 2013 130 143
22. I.J. Llewellyn-Smith Preproglucagon neurons project widely to autonomic control areas in the mouse brain Neuroscience 180 2011 111 121
23. F. Reimann Glucose sensing in L cells: a primary cell study Cell Metab 8 2008 532 539
24. R. Manton Preproglucagon neurons innervate spinal autonomic neurons Proc Physiol Soc 27 2012 PC134
25. N. Thiebaud Expression and activity of glucagon-like peptide 1 in the mouse olfactory bulb. Association of Chemoreception Sciences (AChemS) Chemical Senses 2013 64 10.1093/chemse/bjt036 abstract #P110 p
26. R. Goke Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites Eur J Neurosci 7 1995 2294 2300
27. P.L. McClean The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease J Neurosci 31 2011 6587 6594
28. M.J. During Glucagon-like peptide-1 receptor is involved in learning and neuroprotection Nat Med 9 2003 1173 1179 (Pubitemid 37173702)
29. T. Iwai Glucagon-like peptide-1 inhibits LPS-induced IL-1beta production in cultured rat astrocytes Neurosci Res 55 2006 352 360 (Pubitemid 43866249)
30. C. Knauf Role of central nervous system glucagon-like peptide-1 receptors in enteric glucose sensing Diabetes 57 2008 2603 2612
31. C. Knauf Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage J Clin Invest 115 2005 3554 3563 (Pubitemid 43121843)
32. C. Cabou Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity Diabetes 57 2008 2577 2587
33. H. Yamamoto Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons J Clin Invest 110 2002 43 52 (Pubitemid 34743464)
34. L. Rinaman A functional role for central glucagon-like peptide-1 receptors in lithium chloride-induced anorexia Am J Physiol 277 Pt 2 1999 R1537 R1540
35. M.R. Hayes, K.P. Skibicka, and H.J. Grill Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation Endocrinology 149 2008 4059 4068
36. M.D. Turton A role for glucagon-like peptide-1 in the central regulation of feeding Nature 379 1996 69 72 (Pubitemid 26008136)
37. K. Meeran Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat Endocrinology 140 1999 244 250 (Pubitemid 29011165)
38. R.R. Schick Peptides that regulate food intake: glucagon-like peptide 1-(7-36) amide acts at lateral and medial hypothalamic sites to suppress feeding in rats Am J Physiol Regul Integr Comp Physiol 284 2003 R1427 R1435
39. C. Montrose-Rafizadeh High potency antagonists of the pancreatic glucagon-like peptide-1 receptor J Biol Chem 272 1997 21201 21206 (Pubitemid 27373982)
40. T.E. Thiele Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) receptor antagonist attenuates lithium chloride-induced c-Fos induction in rat brainstem Brain Res 801 1998 164 170 (Pubitemid 28401660)
41. R.J. Seeley The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride J Neurosci 20 2000 1616 1621 (Pubitemid 30220440)
42. M. Tauchi Role of central glucagon-like peptide-1 in hypothalamo- pituitary-adrenocortical facilitation following chronic stress Exp Neurol 210 2008 458 466
43. K.P. Kinzig CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors J Neurosci 23 2003 6163 6170 (Pubitemid 36875615)
44. D.A. Sandoval Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake Diabetes 57 2008 2046 2054
45. M.A. Burmeister Acute activation of central GLP-1 receptors enhances hepatic insulin action and insulin secretion in high-fat-fed, insulin resistant mice Am J Physiol Endocrinol Metab 302 2012 E334 E343
46. A.M. Dossat Nucleus accumbens GLP-1 receptors influence meal size and palatability Am J Physiol Endocrinol Metab 67 2013 E1314 E1320
47. M.R. Hayes, L. Bradley, and H.J. Grill Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling Endocrinology 150 2009 2654 2659
48. S.L. Dickson The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors J Neurosci 32 2012 4812 4820
49. H.J. Grill Attenuation of lipopolysaccharide anorexia by antagonism of caudal brain stem but not forebrain GLP-1-R Am J Physiol Regul Integr Comp Physiol 287 2004 R1190 R1193
50. J.W. Maniscalco, and L. Rinaman Overnight food deprivation markedly attenuates hindbrain noradrenergic, glucagon-like peptide-1, and hypothalamic neural responses to exogenous cholecystokinin in male rats Physiol Behav 121 2013 35 42
51. N. Vrang Gastric distension induces c-Fos in medullary GLP-1/2-containing neurons Am J Physiol Regul Integr Comp Physiol 285 2003 R470 R478
52. C.F. Elias Chemical characterization of leptin-activated neurons in the rat brain J Comp Neurol 423 2000 261 281 (Pubitemid 30421790)
53. L. Rinaman, and E.E. Rothe GLP-1 receptor signaling contributes to anorexigenic effect of centrally administered oxytocin in rats Am J Physiol Regul Integr Comp Physiol 283 2002 R99 R106
54. K. Hisadome Leptin directly depolarizes preproglucagon neurons in the nucleus tractus solitarius: electrical properties of glucagon-like peptide 1 neurons Diabetes 59 2010 1890 1898
55. A. Plamboeck The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty Am J Physiol Gastrointest Liver Physiol 304 2013 G1117 G1127
56. K. Hisadome CCK stimulation of GLP-1 neurons involves {alpha}1-adrenoceptor-mediated increase in glutamatergic synaptic inputs Diabetes 60 2011 2701 2709
57. J.G. Barrera Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function J Neurosci 31 2011 3904 3913