Window of Opportunity for Neuroprotection with an Antioxidant, Allene Oxide Synthase, after Hypoxia-Ischemia in Adult Male Rats

CNS Neuroscience and Therapeutics

Volumn 18, Issue 11, 2012, Pages 887-894

  Mathai, Sam ^a,b   Gunn, Alistair J ^b   Backhaus, Ralph Andrew ^c,d   Guan, Jian ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b THE UNIVERSITY OF AUCKLAND   (New Zealand)

^c Pharma Pacific   (United States)

^d Pacific Brands   (New Zealand)

Author keywords

Allene Oxide Synthase; Neuroprotection; Rats and hypoxic ischemic brain injury

Indexed keywords

ALLENE OXIDE SYNTHASE; ANTIOXIDANT; CASPASE 3; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN DAMAGE; BRAIN INJURY; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; HIPPOCAMPUS; HYPOXIC ISCHEMIC ENCEPHALOPATHY; MALE; MICROGLIA; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; SURVIVAL;

AGE FACTORS; ANIMALS; ANTIOXIDANTS; HYPOXIA-ISCHEMIA, BRAIN; INFUSIONS, INTRAVENTRICULAR; INTRAMOLECULAR OXIDOREDUCTASES; MALE; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; TIME FACTORS;

EID: 84868192331     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12004     Document Type: Article

References (45)

1. Arciniegas DB. Hypoxic-ischemic brain injury: addressing the disconnect between pathophysiology and public policy. NeuroRehabilitation 2010;26:1-4.
2. Niizuma K, Endo H, Chan PH. Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival. J Neurochem 2009;109(Suppl 1):133-138.
3. Inder TE, Volpe JJ. Mechanisms of perinatal brain injury. Semin Neonatol 2000;5:3-16.
4. Bagenholm R, Nilsson UA, Kjellmer I. Formation of free radicals in hypoxic ischemic brain damage in the neonatal rat, assessed by an endogenous spin trap and lipid peroxidation. Brain Res 1997;773:132-138.
5. Northington FJ, Ferriero DM, Graham EM, Traystman RJ, Martin LJ. Early neurodegeneration after hypoxia-ischemia in neonatal rat is necrosis while delayed neuronal death is apoptosis. Neurobiol Dis 2001;8:207-219.
6. Guan J, Bennet L, Gluckman PD, Gunn AJ. Insulin-like growth factor-1 and post-ischemic brain injury. Prog Neurobiol 2003;70:443-462.
7. Silbergleit R, Haywood Y, Fiskum G, Rosenthal RE. Lack of a neuroprotective effect from N-acetylcysteine after cardiac arrest and resuscitation in a canine model. Resuscitation 1999;40:181-186.
8. Kaur C, Ling EA. Antioxidants and neuroprotection in the adult and developing central nervous system. Curr Med Chem 2008;15:3068-3080.
9. Song WC, Brash AR. Purification of an allene oxide synthase and identification of the enzyme as a cytochrome P-450. Science 1991;253:781-784.
10. Feussner I, Wasternack C. The lipoxygenase pathway. Ann Rev Plant Biol 2002;53:22.
11. Song WC, Funk CD, Brash AR. Molecular cloning of an allene oxide synthase: a cytochrome P450 specialized for the metabolism of fatty acid hydroperoxides. Proc Natl Acad Sci USA 1993;90:8519-8523.
12. Pan Z, Durst F, Werck-Reichhart D, et al. The major protein of guayule rubber particles is a cytochrome P450. Characterization based on cDNA cloning and spectroscopic analysis of the solubilized enzyme and its reaction products. J Biol Chem 1995;270:8487-8494.
13. Pan Z, Camara B, Gardner HW, Backhaus RA. Aspirin inhibition and acetylation of the plant cytochrome P450, allene oxide synthase, resembles that of animal prostaglandin endoperoxide H synthase. J Biol Chem 1998;273:18139-18145.
14. Li L, Chang Z, Pan Z, Fu ZQ, Wang X. Modes of heme binding and substrate access for cytochrome P450 CYP74A revealed by crystal structures of allene oxide synthase. Proc Natl Acad Sci USA 2008;105:13883-13888.
15. Backhaus RA, Pan Z, Herickhoff LA. Enzymatic antioxidant of allene oxide for lipid peroxidation in biological systems. US Patent: 6, 132, 711, 2000.
16. Backhaus RA. Cardioprotective therapies based on enzymatic elimination of lipid peroxides by allene oxide synthase. US Patent: 7, 157, 082 2007.
17. Guan J, Williams C, Gunning M, Mallard C, Gluckman P. The effects of IGF-1 treatment after hypoxic-ischemic brain injury in adult rats. J Cereb Blood Flow Metab 1993;13:609-616.
18. Guan J, Williams CE, Skinner SJ, Mallard EC, Gluckman PD. The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats: evidence for a role for IGF binding proteins. Endocrinology 1996;137:893-898.
19. Guan J, Gunn AJ, Sirimanne ES, et al. The window of opportunity for neuronal rescue with insulin-like growth factor-1 after hypoxia-ischemia in rats is critically modulated by cerebral temperature during recovery. J Cereb Blood Flow Metab 2000;20:513-519.
20. Paxinos G, Watson CD. The rat brain stereotaxic coordinations. New York: Academic Press, 1982.
21. Brown AW, Brierley JB. Anoxic-ischaemic cell change in rat brain light microscopic and fine-structural observations. J Neurol Sci 1972;16:59-84.
22. Auer RN, Kalimo H, Olsson Y, Siesjo BK. The temporal evolution of hypoglycemic brain damage. II. Light- and electron-microscopic findings in the hippocampal gyrus and subiculum of the rat. Acta Neuropathol 1985;67:25-36.
23. Guan J, Thomas GB, Lin H, et al. Neuroprotective effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic-ischemic adult rats. Neuropharmacology 2004;47:892-903.
24. Dean JM, Farrag D, Zahkouk SA, et al. Cerebellar white matter injury following systemic endotoxemia in preterm fetal sheep. Neuroscience 2009;160:606-615.
25. Szeto HH. Mitochondria-targeted peptide antioxidants: novel neuroprotective agents. AAPS J 2006;8:E521-E531.
26. Kowaltowski AJ, Vercesi AE. Mitochondrial damage induced by conditions of oxidative stress. Free Radic Biol Med 1999;26:463-471.
27. Zamzami N, Hirsch T, Dallaporta B, Petit PX, Kroemer G. Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis. J Bioenerg Biomembr 1997;29:185-193.
28. Warner DS, Sheng H, Batinic-Haberle I. Oxidants, antioxidants and the ischemic brain. J Exp Biol 2004;207:3221-3231.
29. Gluckman PD, Guan J, Williams C, et al. Asphyxial brain injury-the role of the IGF system. Mol Cell Endocrinol 1998;140:95-99.
30. Guan J, Mathai S, Harris AP, et al. Peripheral administration of a novel diketopiperazine, NNZ 2591, prevents brain injury and improves somatosensory-motor funcion following hypoxia-ischemia in adult rats. Neuropharmacology 2007;53:749-762.
31. Colbourne F, Sutherland GR, Auer RN. Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia. J Neurosci 1999;19:4200-4210.
32. Geddes R, Vannucci RC, Vannucci SJ. Delayed cerebral atrophy following moderate hypoxia-ischemia in the immature rat. Dev Neurosci 2001;23:180-185.
33. Giulian D, Vaca K, Corpuz M. Brain glia release factors with opposing actions upon neuronal survival. J Neurosci 1993;13:29-37.
34. Urban JL, Shepard HM, Rothstein JL, Sugarman BJ, Schreiber H. Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages. Proc Natl Acad Sci USA 1986;83:5233-5237.
35. Piani D, Frei K, Do KQ, Cuenod M, Fontana A. Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate. Neurosci Lett 1991;133:159-162.
36. Beilharz EJ, Williams CE, Dragunow M, Sirimanne ES, Gluckman PD. Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss. Brain Res Mol Brain Res 1995;29:1-14.
37. Guan J, Waldvogel HJ, Faull RL, Gluckman PD, Williams CE. The effects of the N-terminal tripeptide of insulin-like growth factor- 1, glycine-proline-glutamate in different regions following hypoxic- ischemic brain injury in adult rats. Neuroscience 1999;89:649-659.
38. Morikawa E, Moskowitz MA, Huang Z, Yoshida T, Irikura K, Dalkara T. L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke 1994;25:429-435.
39. Kozniewska E, Oseka M, Stys T. Effects of endothelium-derived nitric oxide on cerebral circulation during normoxia and hypoxia in the rat. J Cereb Blood Flow Metab 1992;12:311-317.
40. Yamamoto S, Golanov EV, Berger SB, Reis DJ. Inhibition of nitric oxide synthesis increases focal ischemic infarction in rat. J Cereb Blood Flow Metab 1992;12:717-726.
41. Tanaka K, Fukuuchi Y, Gomi S. Inhibition of nitric oxide synthesis impairs autoregulation of local cerebral blood flow in the rat. NeuroReport 1993;4:267-270.
42. Yant LJ, Ran Q, Rao L, et al. The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic Biol Med 2003;34:496-502.
43. Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H. Trends in oxidative aging theories. Free Radic Biol Med 2007;43:477-503.
44. Seiler A, Schneider M, Forster H, et al. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab 2008;8:237-248.
45. Ran Q, Gu M, Van Remmen H, Strong R, Roberts JL, Richardson A. Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity. J Neurosci Res 2006;84:202-208.