Utilizing dynamic light scattering as a process analytical technology for protein folding and aggregation monitoring in vaccine manufacturing

Journal of Pharmaceutical Sciences

Volumn 102, Issue 12, 2013, Pages 4284-4290

  Yu, Zhou ^a   Reid, Jennifer C ^a   Yang, Yan Ping ^a  

^a Sanofi Pasteur   (Canada)

Author keywords

biopharmaceuticals characterization; light scattering (dynamic); particle sizing; process analytical technology (PAT); protein aggregation; protein folding refolding; vaccines

Indexed keywords

BOVINE SERUM ALBUMIN; RECOMBINANT PROTEIN; RECOMBINANT SP1 PROTEIN; UNCLASSIFIED DRUG; VACCINE;

ANALYTIC METHOD; ARTICLE; BACTERIAL CELL; CELL INCLUSION; DYNAMIC LIGHT SCATTERING; GEL PERMEATION CHROMATOGRAPHY; LIGHT SCATTERING; NONHUMAN; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEIN REFOLDING; PROTEIN UNFOLDING; SOLUBILIZATION; VACCINE PRODUCTION;

BIOPHARMACEUTICALS CHARACTERIZATION; LIGHT SCATTERING (DYNAMIC); PARTICLE SIZING; PROCESS ANALYTICAL TECHNOLOGY (PAT); PROTEIN AGGREGATION; PROTEIN FOLDING/REFOLDING; VACCINES;

ANIMALS; CATTLE; HUMANS; IMMUNOGLOBULINS; LIGHT; PROTEIN DENATURATION; PROTEIN FOLDING; RECOMBINANT FUSION PROTEINS; SCATTERING, RADIATION; SERUM ALBUMIN, BOVINE; SOLUBILITY; VACCINES, SYNTHETIC;

EID: 84888200366     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23746     Document Type: Article

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