Infantile fibrosarcoma - A clinical and histologic mimicker of vascular malformations: Case report and review of the literature

Pediatric and Developmental Pathology

Volumn 16, Issue 5, 2013, Pages 357-363

  Hu, Zhihong ^a   Chou, Pauline M ^b   Jennings, Lawrence J ^b   Arva, Nicoleta C ^b  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b CHILDREN'S MEMORIAL HOSPITAL   (United States)

Author keywords

ETV6 NTRK3 fusion product; Infantile fibrosarcoma; Vascular malformation

Indexed keywords

TRANSCRIPTION FACTOR ETV6;

ARTICLE; BIOPSY; CASE REPORT; CHILD; CHROMATIN; ECHOGRAPHY; ENDOTHELIUM CELL; FEMALE; FIBROSARCOMA; HEMANGIOENDOTHELIOMA; HUMAN; INFANT; INFANTILE FIBROSARCOMA; INFLAMMATORY CELL; LYMPHANGIOMA; MICROSCOPY; PRIORITY JOURNAL; SPINDLE CELL;

AXILLA; DIAGNOSIS, DIFFERENTIAL; FEMALE; FIBROSARCOMA; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; ONCOGENE PROTEINS, FUSION; POLYMERASE CHAIN REACTION; SOFT TISSUE NEOPLASMS; VASCULAR MALFORMATIONS;

EID: 84888153167     PISSN: 10935266     EISSN: 16155742     Source Type: Journal    
DOI: 10.2350/13-05-1335-CR.1     Document Type: Article

References (28)

1. Boon LM, Fishman SJ, Lund DP, Mulliken JB. Congenital fibrosarcoma masquerading as congenital hemangioma: report of two cases. J Pediatr Surg 1995;30:1378-1381. (Pubitemid 26063501)
2. Cisse M, Machet L, Le Touze A, Machet MC, Lejars O, Lorette G. Infantile fibrosarcoma mimicking rapidly involuting congenital haemangioma (RICH). Ann Dermatol Venereol 2008;135:53-57. (Pubitemid 351970348)
3. Jain D, Kohli K. Congenital infantile fibrosarcoma: a clinical mimicker of hemangioma. Cutis 2012;89:61-64.
4. Kagawa K, Park S, Taniguchi K. Infantile fibrosarcoma. Report of two cases. Scand J Plast Reconstr Surg Hand Surg 1999;33:105-109. (Pubitemid 29371072)
5. Kerl K, Nowacki M, Leuschner I, Masjosthusmann K, Fruhwald MC. Infantile fibrosarcoma-an important differential diagnosis of congenital vascular tumors. Pediatr Hematol Oncol 2012;29:545-548.
6. Kimura C, Kitamura T, Sugihara T. A case of congenital infantile fibrosarcoma of the right hand. J Dermatol 1998;25:735-741. (Pubitemid 28566711)
7. Mnif H, Zrig M, Maazoun K, et al. Congenital infantile fibrosarcoma of the forearm. Chir Main 2011;30:148-151.
8. Muzaffar AR, Friedrich JB, Lu KK, Hanel DP. Infantile fibrosarcoma of the hand associated with coagulopathy. Plast Reconstr Surg 2006;117:81e-86e. (Pubitemid 44324433)
9. Sukop A, Malis J, Tvrdek M, et al. Diagnostic dilemmas of infantile sarcoma of the forearm. Acta Chir Plast 2010;52:19-21.
10. Yan AC, Chamlin SL, Liang MG, et al. Congenital infantile fibrosarcoma: a masquerader of ulcerated hemangioma. Pediatr Dermatol 2006;23:330-334. (Pubitemid 44199418)
11. Pousti TJ, Upton J, Loh M, Grier H. Congenital fibrosarcoma of the upper extremity. Plast Reconstr Surg 1998;102:1158-1162. (Pubitemid 28414646)
12. Al-Salem AH. Congenital-infantile fibrosarcoma masquerading as sacrococcygeal teratoma. J Pediatr Surg 2011;46:2177-2180.
13. Razek AA, Huang BY. Soft tissue tumors of the head and neck: imaging-based review of the WHO classification. Radiographics 2011;31:1923-1954.
14. Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet 1998;18:184-187. (Pubitemid 28082471)
15. Lannon CL, Sorensen PH. ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. Semin Cancer Biol 2005;15:215-223.
16. Wai DH, Knezevich SR, Lucas T, Jansen B, Kay RJ, Sorensen PH. The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells. Oncogene 2000;19:906-915. (Pubitemid 30153748)
17. Liu Q, Schwaller J, Kutok J, et al. Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukaemia. EMBO J 2000;19:1827-1838. (Pubitemid 30204394)
18. Tognon C, Knezevich SR, Huntsman D, et al. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell 2002;2:367-376. (Pubitemid 41039103)
19. Bourgeois JM, Knezevich SR, Mathers JA, Sorensen PH. Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. Am J Surg Pathol 2000;24:937-946. (Pubitemid 30430481)
20. Argani P, Fritsch M, Kadkol SS, Schuster A, Beckwith JB, Perlman EJ. Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin embedded tissue: application to challenging pediatric renal stromal tumors. Mod Pathol 2000;13:29-36. (Pubitemid 30077901)
21. Eguchi M, Eguchi-Ishimae M, Tojo A, et al. Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25). Blood 1999;93:1355-1363. (Pubitemid 29076151)
22. Cristofaro B, Stone OA, Caporali A, et al. Neurotrophin-3 is a novel angiogenic factor capable of therapeutic neovascularization in a mouse model of limb ischemia. Arterioscler Thromb Vasc Biol 2010;30:1143-1150.
23. Miura K, Han G, Sano M, Tsutsui Y. Regression of congenital fibrosarcoma to hemangiomatous remnant with histological and genetic findings. Pathol Int 2002;52:612-618. (Pubitemid 35335044)
24. Alaggio R, Barisani D, Ninfo V, Rosolen A, Coffin CM. Morphologic overlap between infantile myofibromatosis and infantile fibrosarcoma: a pitfall in diagnosis. Pediatr Dev Pathol 2008;11:355-362.
25. Variend S, Bax NM, van Gorp J. Are infantile myofibromatosis, congenital fibrosarcoma and congenital haemangiopericytoma histogenetically related? Histopathology 1995;26:57-62.
26. Blizniukov OP, Perevoshchikov AG, Poliakov VG. Histogenesis of infantile fibrosarcoma. Arkh Patol 2009;71:8-12.
27. Ferguson WS. Advances in the adjuvant treatment of infantile fibrosarcoma. Expert Rev Anticancer Ther 2003;3:185-191. (Pubitemid 36503396)
28. Frieden IJ, Rogers M, Garzon MC. Conditions masquerading as infantile haemangioma: part 2. Australas J Dermatol 2009;50:153-168; quiz 169-170.