Akt regulates TPP1 homodimerization and telomere protection

Aging Cell

Volumn 12, Issue 6, 2013, Pages 1091-1099

  Han, Xin ^a   Liu, Dan ^b   Zhang, Yi ^b   Li, Yujing ^a   Lu, Weisi ^a   Chen, Junjie ^c   Songyang, Zhou ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Akt; Telomere protection; TPP1

Indexed keywords

HOMODIMER; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; TELOMERE BINDING PROTEIN; TPP1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CELL METABOLISM; CELL PROLIFERATION; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIMERIZATION; DNA REPAIR; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FLUORESCENCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TELOMERE; TELOMERE HOMEOSTASIS; WILD TYPE;

EUKARYOTA; MAMMALIA;

AKT; TELOMERE PROTECTION; TPP1;

AMINOPEPTIDASES; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; HUMANS; ISOENZYMES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS C-AKT; SERINE PROTEASES; TELOMERE; TELOMERE-BINDING PROTEINS;

EID: 84888138898     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12137     Document Type: Article

References (41)

1. Armanios M, Blackburn EH (2012) The telomere syndromes. Nat. Rev. Genet. 13, 693-704.
2. Carnero A (2010) The PKB/AKT pathway in cancer. Curr. Pharm. Des. 16, 34-44.
3. Chen YC, Teng SC, Wu KJ (2009) Phosphorylation of telomeric repeat binding factor 1 (TRF1) by Akt causes telomere shortening. Cancer Invest. 27, 24-28.
4. Chung J, Khadka P, Chung IK (2012) Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation. J. Cell Sci. 125, 2684-2697.
5. Deng Y, Chan SS, Chang S (2008) Telomere dysfunction and tumour suppression: the senescence connection. Nat. Rev. Cancer 8, 450-458.
6. Deng R, Tang J, Ma JG, Chen SP, Xia LP, Zhou WJ, Li DD, Feng GK, Zeng YX, Zhu XF (2011) PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation. Oncogene 30, 944-955.
7. Donate LE, Blasco MA (2011) Telomeres in cancer and ageing. Philos. Trans. R. Soc. Lond. B Biol. Sci. 366, 76-84.
8. Frias C, Pampalona J, Genesca A, Tusell L (2012) Telomere dysfunction and genome instability. Front. Biosci. 17, 2181-2196.
9. Haendeler J, Hoffmann J, Rahman S, Zeiher AM, Dimmeler S (2003) Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation. FEBS Lett. 536, 180-186.
10. Heiss NS, Knight SW, Vulliamy TJ, Klauck SM, Wiemann S, Mason PJ, Poustka A, Dokal I (1998) X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions. Nat. Genet. 19, 32-38.
11. Hu CD, Chinenov Y, Kerppola TK (2002) Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation. Mol. Cell 9, 789-798.
12. Kang SS, Kwon T, Kwon DY, Do SI (1999) Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J. Biol. Chem. 274, 13085-13090.
13. Kim D, Kim S, Koh H, Yoon SO, Chung AS, Cho KS, Chung J (2001) Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J. 15, 1953-1962.
14. Kim H, Lee OH, Xin H, Chen LY, Qin J, Chae HK, Lin SY, Safari A, Liu D, Songyang Z (2009) TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Nat. Struct. Mol. Biol. 16, 372-379.
15. Kloet DE, Burgering BM (2011) The PKB/FOXO switch in aging and cancer. Biochim. Biophys. Acta 1813, 1926-1937.
16. de Lange T (2005) Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19, 2100-2110.
17. Lee OH, Kim H, He Q, Baek HJ, Yang D, Chen LY, Liang J, Chae HK, Safari A, Liu D, Songyang Z (2011) Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Mol. Cell. Proteomics 10, M110 001628.
18. Liang J, Wan M, Zhang Y, Gu P, Xin H, Jung SY, Qin J, Wong J, Cooney AJ, Liu D, Songyang Z (2008) Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat. Cell Biol. 10, 731-739.
19. Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z (2004) PTOP interacts with POT1 and regulates its localization to telomeres. Nat. Cell Biol. 6, 673-680.
20. Manning BD, Cantley LC (2007) AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274.
21. Nandakumar J, Cech TR (2013) Finding the end: recruitment of telomerase to telomeres. Nat. Rev. Mol. Cell Biol. 14, 69-82.
22. Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR (2012) The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature 492, 285-289.
23. O'Connor MS, Safari A, Xin H, Liu D, Songyang Z (2006) A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc. Natl Acad. Sci. USA 103, 11874-11879.
24. O'Sullivan RJ, Karlseder J (2010) Telomeres: protecting chromosomes against genome instability. Nat. Rev. Mol. Cell Biol. 11, 171-181.
25. Palm W, de Lange T (2008) How shelterin protects mammalian telomeres. Annu. Rev. Genet. 42, 301-334.
26. Sasa GS, Ribes-Zamora A, Nelson ND, Bertuch AA (2012) Three novel truncating TINF2 mutations causing severe dyskeratosis congenita in early childhood. Clin. Genet. 81, 470-478.
27. Savage SA, Giri N, Baerlocher GM, Orr N, Lansdorp PM, Alter BP (2008) TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. Am. J. Hum. Genet. 82, 501-509.
28. Shay JW, Wright WE (2011) Role of telomeres and telomerase in cancer. Semin. Cancer Biol. 21, 349-353.
29. Takai KK, Kibe T, Donigian JR, Frescas D, de Lange T (2011) Telomere protection by TPP1/POT1 requires tethering to TIN2. Mol. Cell 44, 647-659.
30. Tzivion G, Hay N (2011) PI3K-AKT-FoxO axis in cancer and aging. Biochim. Biophys. Acta 1813, 1925.
31. Vulliamy T, Beswick R, Kirwan M, Marrone A, Digweed M, Walne A, Dokal I (2008) Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita. Proc. Natl Acad. Sci. USA 105, 8073-8078.
32. Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR (1998) Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. Biochem. J. 331(Pt 1), 299-308.
33. Walne AJ, Vulliamy T, Beswick R, Kirwan M, Dokal I (2008) TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes. Blood 112, 3594-3600.
34. Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, Cech TR, Lei M (2007) The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature 445, 506-510.
35. Wilson CG, Magliery TJ, Regan L (2004) Detecting protein-protein interactions with GFP-fragment reassembly. Nat. Methods 1, 255-262.
36. Xin H, Liu D, Wan M, Safari A, Kim H, Sun W, O'Connor MS, Songyang Z (2007) TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature 445, 559-562.
37. Xin H, Liu D, Songyang Z (2008) The telosome/shelterin complex and its functions. Genome Biol. 9, 232.
38. Xu N, Hegarat N, Black EJ, Scott MT, Hochegger H, Gillespie DA (2010) Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2. J. Cell Biol. 190, 297-305.
39. Zhang Y, Chen LY, Han X, Xie W, Kim H, Yang D, Liu D, Songyang Z (2013) Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment. Proc. Natl Acad. Sci. USA 110, 5457-5462.
40. Zhong F, Savage SA, Shkreli M, Giri N, Jessop L, Myers T, Chen R, Alter BP, Artandi SE (2011) Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita. Genes Dev. 25, 11-16.
41. Zhong FL, Batista LF, Freund A, Pech MF, Venteicher AS, Artandi SE (2012) TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell 150, 481-494.