Unblinded Adaptive Statistical Information Design Based on Clinical Endpoint or Biomarker

Statistics in Biopharmaceutical Research

Volumn 5, Issue 4, 2013, Pages 293-310

  Wang, Sue Jane ^a   Brannath, Werner ^b   Brückner, Matthias ^b   James Hung, H M ^a   Koch, Armin ^c  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b UNIVERSITY OF BREMEN   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Adaptive weighted (or unweighted) Z statistic; Biomarker (or surrogate) outcome; Correlation; Heterogeneity (or inconsistency); Maximum Type I error probability

Indexed keywords

BIOLOGICAL MARKER;

ADAPTIVE STATISTICAL INFORMATION; ARTICLE; HUMAN; MEASUREMENT ERROR; OUTCOME ASSESSMENT; PROBABILITY; RANDOMIZED CONTROLLED TRIAL (TOPIC); SAMPLE SIZE; STATISTICAL PARAMETERS; STATISTICAL SIGNIFICANCE; STATISTICS;

EID: 84888137381     PISSN: None     EISSN: 19466315     Source Type: Journal    
DOI: 10.1080/19466315.2013.791639     Document Type: Article

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