Type I error rate control in adaptive designs for confirmatory clinical trials with treatment selection at interim

Pharmaceutical Statistics

Volumn 10, Issue 2, 2011, Pages 96-104

  Posch, Martin ^a   Maurer, Willi ^b   Bretz, Frank ^b,c  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b NOVARTIS PHARMA AG   (Switzerland)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Adaptive designs; Bonferroni; Conditional error rate; Familywise error rate; Holm; Sample size reallocation

Indexed keywords

ARTICLE; CLINICAL TRIAL (TOPIC); COMPARATIVE STUDY; CONTROL; EVALUATION; HUMAN; METHODOLOGY; PATIENT CARE; SAMPLE SIZE; SIMULATION; STATISTICAL ANALYSIS; SYSTEMATIC ERROR; TREATMENT INDICATION;

CLINICAL TRIALS AS TOPIC; COMPUTER SIMULATION; HUMANS; RESEARCH DESIGN; SAMPLE SIZE;

EID: 78249253755     PISSN: 15391604     EISSN: 15391612     Source Type: Journal    
DOI: 10.1002/pst.413     Document Type: Article

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