Different tocopherol isoforms vary in capacity to scavenge free radicals, prevent inflammatory response, and induce apoptosis in both adult- and fetal-derived intestinal epithelial cells

BioFactors

Volumn 39, Issue 6, 2013, Pages 663-671

  Elisia, Ingrid ^a   Kitts, David D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Apoptosis; Inflammation; Intestine; Oxidative stress; Tocopherol

Indexed keywords

DELTA TOCOPHEROL; FREE RADICAL; GAMMA INTERFERON; GAMMA TOCOPHEROL; INTERLEUKIN 8; PEROXY RADICAL; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTAGLANDIN E2; VEGETABLE OIL;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; ARTIFICIAL MILK; BREAST MILK; CELL DEATH; CELL DIFFERENTIATION; CELL MEMBRANE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DIETARY INTAKE; DRUG EFFICACY; INFLAMMATION; INTESTINE EPITHELIUM CELL; OXIDATIVE STRESS; PRIORITY JOURNAL;

APOPTOSIS; INFLAMMATION; INTESTINE; OXIDATIVE STRESS; TOCOPHEROL;

ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CACO-2 CELLS; CELL SURVIVAL; EPITHELIAL CELLS; FREE RADICAL SCAVENGERS; FREE RADICALS; HUMANS; INFLAMMATION MEDIATORS; INTESTINAL MUCOSA; OXIDATION-REDUCTION; OXIDATIVE STRESS; TOCOPHEROLS;

EID: 84888136254     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1132     Document Type: Article

References (50)

1. Brigelius-Flohé, R. (2006) Bioactivity of vitamin E. Nutr. Res. Rev. 19, 174-186.
2. Evans, H. M. and Bishop, K. S. (1922) On the existence of a hitherto unrecognized dietary factor essential for reproduction. Science 56, 650-651.
3. Bieri, J. G. and McKenna, M. C. (1981) Expressing dietary values for fat-soluble vitamins: changes in concepts and terminology. Am. J. Clin. Nutr. 34, 289-295.
4. Brigelius-Flohé, R. and Traber, M. G. (1999) Vitamin E: function and metabolism. FASEB J. 13, 1145-1155.
5. Elisia, I., Young, J. W., Yuan, Y. V., and Kitts, D. D. (2013) Association between tocopherol isoform composition and lipid oxidation in selected multiple edible oils. Food Res. Int. 52, 508-514.
6. United States Census Bureau. Fats and oils: production, consumption, and stocks. Available at: http://www.census.gov/manufacturing/cir/historical_data/m311k/index.html. Accessed on March 11, 2013.
7. Berdnikovs, S., Abdala-Valencia, H., McCary, C., Somand, M., Cole, R., et al. (2009) Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment. J. Immunol. 182, 4395-4405.
8. European Food Safety Authority. (2008) Opinion on mixed tocopherols, tocotrienol tocopherol and tocotrienols as sources for vitamin E added as a nutritional substance in food supplements. EFSA J. 640, 1-34.
9. Committee on the Evaluation of the Addition of Ingredients New to Infant Formula. (2004) Infant Formula: Evaluating the Safety of New Ingredients. National Academies Press, Washington, D.C.
10. Martysiak-Zurowska, D., Szlagatys-Sidorkiewicz, A., and Zagierski, M. (2012) Concentrations of alpha- and gamma-tocopherols in human breast milk during the first months of lactation and in infant formulas. Matern. Child Nutr., in press. DOI: 10.1111/j.1740-8709.2012.00401.x.
11. Senanayake, S. P. J. N. and Fichtali, J. (2006) Single-cell oils as sources of nutraceutical and specialty lipids: Processing technologies and applications. In Nutraceutical and Specialty Lipids and their Co-Products. (Shahidi, F., ed.). pp. 264, CRC Press, Boca Raton.
12. Elisia, I. and Kitts, D. D. (2011) Quantitation of hexanal as an index of lipid oxidation in human milk and association with antioxidant components. J. Clin. Biochem. Nutr. 49, 147-152.
13. Kamal-Eldin, A. and Appelqvist, L. Å. (1996) The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31, 671-701.
14. Hosomi, A., Arita, M., Sato, Y., Kiyose, C., Ueda, T., et al. (1997) Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Lett. 409, 105-108.
15. Sontag, T. J. and Parker, R. S. (2007) Influence of major structural features of tocopherols and tocotrienols on their ω-oxidation by tocopherol ω-hydroxylase. J. Lipid Res. 48, 1090-1098.
16. Friel, J. K., Friesen, R. W., Harding, S. V., and Roberts, L. J. (2004) Evidence of oxidative stress in full-term healthy infants. Pediatr. Res. 56, 878-882.
17. Azzi, A., Ricciarelli, R., and Zingg, J. M. (2002) Non-antioxidant molecular functions of α-tocopherol (vitamin E). FEBS Lett. 519, 8-10.
18. Huang, D., Ou, B., Hampsch-Woodill, M., Flanagan, J. A., and Deemer, E. K. (2002) Development and validation of oxygen radical absorbance capacity assay for lipophilic antioxidants using randomly methylated β-cyclodextrin as the solubility enhancer. J. Agric. Food Chem. 50, 1815-1821.
19. Tijerina-Sáenz, A., Elisia, I., Innis, S. M., Friel, J. K., and Kitts, D. D. (2009) Use of ORAC to assess oxidative stability in human milk. J. Food Compost. Anal. 22, 694-698.
20. McCormick, C. C. and Parker, R. S. (2004) The cytotoxicity of vitamin E is both vitamer- and cell-specific and involves a selectable trait. J. Nutr. 134, 3335-3342.
21. Reboul, E., Thap, S., Perrot, E., Amiot, M. J., Lairon, D., et al. (2007) Effect of the main dietary antioxidants (carotenoids, γ-tocopherol, polyphenols, and vitamin C) on α-tocopherol absorption. Eur. J. Clin. Nutr. 61, 1167-1173.
22. Okimoto, Y., Watanabe, A., Niki, E., Yamashita, T., and Noguchi, N. (2000) A novel fluorescent probe diphenyl-1-pyrenylphosphine to follow lipid peroxidation in cell membranes. FEBS Lett. 474, 137-140.
23. Takahashi, M., Shibata, M., and Niki, E. (2001) Estimation of lipid peroxidation of live cells using a fluorescent probe, diphenyl-1-pyrenylphosphine. Free Radic. Biol. Med. 31, 164-174.
24. Chen, X. M. and Kitts, D. D. (2008) Determining conditions for nitric oxide synthesis in Caco-2 cells using taguchi and factorial experimental designs. Anal. Biochem. 381, 185-192.
25. Elisia, I., Popovich, D. G., Hu, C., and Kitts, D. D. (2008) Evaluation of viability assays for anthocyanins in cultured cells. Phytochem. Anal. 19, 479-486.
26. Hidalgo, I. J. (1996) Cultured intestinal epithelial cell models. In Models for Assessing Drug Absorption and Metabolism. (Borchardt, R. T., Smith, P. L., Wilson, G., eds.). pp. 35-50, Plenum Publishing Corporation, New York.
27. Hirai, C., Ichiba, H., Saito, M., Shintaku, H., Yamano, T., et al. (2002) Trophic effect of multiple growth factors in amniotic fluid or human milk on cultured human fetal small intestinal cells. J. Pediatr. Gastroenterol. Nutr. 34, 524-528.
28. Artursson, P., Palm, K., and Luthman, K. (2001) Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv. Drug Delivery Rev. 46, 27-43.
29. Shah, P., Jogani, V., Bagchi, T., and Misra, A. (2006) Role of Caco-2 cell monolayers in prediction of intestinal drug absorption. Biotechnol. Prog. 22, 186-198.
30. American Tissue Culture Collection. Product description FHs 74 Int. Available at: http://www.atcc.org/Products/All/CCL-241.aspx. Accessed on March 12, 2013.
31. Tran, K. and Chan, A. (1992) Comparative uptake of α- and γ-tocopherol by human endothelial cells. Lipids 27, 38-41.
32. Gao, R., Stone, W., Huang, T., Papas, A., and Qui, M. (2002) The uptake of tocopherols by RAW 264.7 macrophages. Nutr. J. 1, 2.
33. U.S. Environmental Protection Agency. (2011) Estimation Program Interface (EPI) Suite™ for Microsoft® Windows, Version 4.10. United States Environmental Protection Agency, Washington, DC, USA.
34. Chaiyasit, W., McClements, D. J., and Decker, E. A. (2005) The relationship between the physicochemical properties of antioxidants and their ability to inhibit lipid oxidation in bulk oil and oil-in-water emulsions. J. Agric. Food Chem. 53, 4982-4988.
35. Chan, A. and Tran, K. (1990) The uptake of (R, R, R) α-tocopherol by human endothelial cells in culture. Lipids 25, 17-21.
36. DeForge, L. E., Preston, A. M., Takeuchi, E., Kenney, J., Boxer, L. A., et al. (1993) Regulation of interleukin 8 gene expression by oxidant stress. J. Biol. Chem. 268, 25568-25576.
37. Hoffmann, E., Dittrich-Breiholz, O., Holtmann, H., and Kracht, M. (2002) Multiple control of interleukin-8 gene expression. J. Leukoc. Biol. 72, 847-855.
38. Claud, E. C., Savidge, T., and Walker, W. A. (2003) Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors. Pediatr. Res. 53, 419-425.
39. Tasinato, A., Boscoboinik, D., Bartoli, G. M., Maroni, P., and Azzi, A. (1995) d-Alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Proc. Natl. Acad. Sci. USA 92, 12190-12194.
40. Kempná, P., Reiter, E., Arock, M., Azzi, A., and Zingg, J. M. (2004) Inhibition of HMC-1 mast cell proliferation by vitamin E. J. Biol. Chem. 279, 50700-50709.
41. Park, K. A., Byun, H. S., Won, M., Yang, K. J., Shin, S., et al. (2006) Sustained activation of protein kinase C downregulates nuclear factor-κB signaling by dissociation of IKK-γ and Hsp90 complex in human colonic epithelial cells. Carcinogenesis 28, 71-80.
42. Song, G., Ouyang, G., and Bao, S. (2005) The activation of Akt/PKB signaling pathway and cell survival. J. Cell Mol. Med. 9, 59-71.
43. Dan, H. C., Cooper, M. J., Cogswell, P. C., Duncan, J. A., Ting, J. P. Y., et al. (2008) Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKK. Genes Dev. 22, 1490-1500.
44. Nanthakumar, N., Meng, D., Goldstein, A. M., Zhu, W., Lu, L., et al. (2011) The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: an immature innate immune response. PLoS One 6(3), e17776.
45. Neu, J. and Walker, W. A. (2011) Necrotizing cnterocolitis. N. Engl. J. Med. 364, 255-264.
46. Nishikori, M. (2005) Classical and alternative NF-κB activation pathways and their roles in lymphoid malignancies. J. Clin. Exp. Hematopathol. 45, 15-24.
47. Nguyen, T., Nioi, P., and Pickett, C. B. (2009) The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J. Biol. Chem. 284, 13291-13295.
48. Campbell, S., Stone, W., Lee, S., Whaley, S., Yang, H., et al. (2006) Comparative effects of RRR-alpha- and RRR-gamma-tocopherol on proliferation and apoptosis in human colon cancer cell lines. BMC Cancer 6, 13.
49. Atkinson, J., Epand, R. F., and Epand, R. M. (2008) Tocopherols and tocotrienols in membranes: a critical review. Free Radic. Biol. Med. 44, 739-764.
50. Hackam, D. J., Upperman, J. S., Grishin, A., and Ford, H. R. (2005) Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis. Semin. Pediatr. Surg. 14, 49-57.