Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC)

Biochemical and Biophysical Research Communications

Volumn 440, Issue 3, 2013, Pages 364-370

  Hammoudi, Abeer ^a   Song, Fei ^a,b   Reed, Karen R ^b   Jenkins, Rosalind E ^a   Meniel, Valerie S ^b   Watson, Alastair J M ^c   Pritchard, D Mark ^a   Clarke, Alan R ^b   Jenkins, John R ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Adenomatous polyposis coli; AhCre+Apc+ +; AhCre+Apcfl fl; Apc; ApcMin +; Biomarkers; CK18; Colorectal cancer; CRC; CTBRC; DDX5; ECE; FAP; FDR; GFOBt; HSPD1; I.p.; IHC; IPA; ITRAQ; LC MS MS; MMTS; NCL; PCR; PHB; Proteomics; ROC; RPL6; SEM; TCEP; TEAB; TFA; WB

Indexed keywords

ALBUMIN; ALPHA CATENIN; APC PROTEIN; BIOLOGICAL MARKER; CARBAMOYL PHOSPHATE SYNTHASE; CHAPERONIN 60; CYTOKERATIN 18; DEAD BOX PROTEIN 5; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN BETA CHAIN; HISTONE H2AX; MESSENGER RNA; NUCLEOLIN; PROHIBITIN; RIBOSOME PROTEIN L35; RIBOSOME PROTEIN L6; TUMOR MARKER; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE DELETION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SMALL INTESTINE; UPREGULATION; WESTERN BLOTTING;

MURINAE; MUS; MUS MUSCULUS;

ACUTE CONDITIONAL TRANSGENIC DELETION OF THE APC GENE IN THE MURINE INTESTINAL EPITHELIUM; ADENOMATOUS POLYPOSIS COLI; AHCRE(+)APC(+/+); AHCRE(+)APC(FL)(/)(FL); APC; APC(MIN/+); BIOMARKERS; CANCER TISSUE BANK RESEARCH CENTRE; CK18; COLORECTAL CANCER; CRC; CTBRC; CYTOKERATIN 18; DDX5; DEAD (ASP-GLU-ALA-ASP) BOX POLYPEPTIDE 5; ECE; EPITHELIAL CELL EXTRACTS; FALSE DISCOVERY RATE; FAMILIAL ADENOMATOUS POLYPOSIS; FAP; FDR; GERMLINE MUTATIONS IN THE APC GENE, SPONTANEOUSLY DEVELOP MULTIPLE INTESTINAL ADENOMAS; GFOBT; GUAIAC FAECAL BLOOD TEST; HEAT SHOCK 60KDA PROTEIN 1 (CHAPERONIN); HSPD1; I.P.; IHC; IMMUNOHISTOCHEMISTRY; INGENUITY PATHWAYS ANALYSIS; INTRA-PERITONEAL; IPA; ISOBARIC TAGS FOR RELATIVE AND ABSOLUTE QUANTIFICATION; ITRAQ; LC MS/MS; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; METHYLMETHANETHIOSULFONATE; MMTS; NCL; NUCLEOLIN; PCR; PHB; POLYMERASE CHAIN REACTION; PROHIBITIN; PROTEOMICS; RECEIVER OPERATING CHARACTERISTIC; RIBOSOMAL PROTEIN L6; ROC; RPL6; SEM; STANDARD ERROR OF MEAN; TCEP; TEAB; TFA; TRIETHYLAMMONIUM BICARBONATE; TRIFLUOROACETIC ACID; TRIS(2-CARBOXYETHYL)PHOSPHINE; WB; WESTERN BLOTTING; WILD TYPE CONTROL FOR ACUTE CONDITIONAL TRANSGENIC DELETION OF THE APC GENE IN THE MURINE INTESTINAL EPITHELIUM;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; COLORECTAL NEOPLASMS; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTESTINAL MUCOSA; MICE; MICE, TRANSGENIC; PROTEOMICS; TUMOR MARKERS, BIOLOGICAL;

EID: 84888133289     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.08.076     Document Type: Article

References (24)

1. Hewitson P., Glasziou P., Watson E., et al. Cochrane systematic review of colorectal cancer screening using the fecal occult blood test (hemoccult): an update. Am. J. Gastroenterol. 2008, 103:1541-1549.
2. Tonus C., Sellinger M., Koss K., et al. Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening: a meta-analysis. World. J. Gastroenterol. 2012, 18:4004-4011.
3. Burch J.A., Soares-Weiser K., St John D.J., et al. Diagnostic accuracy of faecal occult blood tests used in screening for colorectal cancer: a systematic review. J. Med. Screen. 2007, 14:132-137.
4. Kinzler K.W., Nilbert M.C., Su L.K., et al. Identification of FAP locus genes from chromosome 5q21. Science 1991, 253:661-665.
5. Moser A.R., Pitot H.C., Dove W.F. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 1990, 247:322-324.
6. Calvert P.M., Frucht H. The genetics of colorectal cancer. Ann. Intern. Med. 2002, 137:603-612.
7. Sansom O.J., Reed K.R., Hayes A.J., et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev. 2004, 18:1385-1390.
8. Unwin R.D., Smith D.L., Blinco D., et al. Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells. Blood 2006, 107:4687-4694.
9. Kitteringham N.R., Abdullah A., Walsh J., et al. Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. J. Proteomics 2010, 73:1612-1631.
10. Rowe C., Goldring C.E., Kitteringham N.R., et al. Network analysis of primary hepatocyte dedifferentiation using a shotgun proteomics approach. J. Proteome Res. 2010, 9:2658-2668.
11. Tang W.H., Halpern B.R., Shilov I.V., et al. Discovering known and unanticipated protein modifications using MS/MS database searching. Anal. Chem. 2005, 77:3931-3946.
12. Tang W.H., Shilov I.V., Seymour S.L. Nonlinear fitting method for determining local false discovery rates from decoy database searches. J. Proteome Res. 2008, 7:3661-3667.
13. Barker C.R., Hamlett J., Pennington S.R., et al. The topoisomerase II-Hsp90 complex: a new chemotherapeutic target?. Int. J. Cancer 2006, 118:2685-2693.
14. Jung Y., Lee S., Choi H.S., et al. Clinical validation of colorectal cancer biomarkers identified from bioinformatics analysis of public expression data. Clin. Cancer Res. 2011, 17:700-709.
15. Caldwell G.M., Jones C.E., Ashley A.M., et al. Wnt signalling in adenomas of familial adenomatous polyposis patients. Br. J. Cancer 2010, 103:910-917.
16. Fearnhead N.S., Britton M.P., Bodmer W.F. The ABC of APC. Hum. Mol. Genet. 2001, 10:721-733.
17. Taketo M.M. Mouse models of gastrointestinal tumors. Cancer Sci. 2006, 97:355-361.
18. Hanash S.M., Pitteri S.J., Faca V.M. Mining the plasma proteome for cancer biomarkers. Nature 2008, 452:571-579.
19. Wang H., Hanash S. Intact-protein analysis system for discovery of serum-based disease biomarkers. Methods Mol. Biol. 2011, 728:69-85.
20. Tian Q., Stepaniants S.B., Mao M., et al. Integrated genomic and proteomic analyses of gene expression in Mammalian cells. Mol. Cell. Proteomics 2004, 3:960-969.
21. Jenkins J.R. A proteomic approach to identifying new drug targets (potentiating topoisomerase II poisons). Br. J. Radiol. 2008, 81(1):S69-S77.
22. Makino T., Yamasaki M., Takeno A., et al. Cytokeratins 18 and 8 are poor prognostic markers in patients with squamous cell carcinoma of the oesophagus. Br. J. Cancer 2009, 101:1298-1306.
23. Chen D., Chen F., Lu X., et al. Identification of prohibitin as a potential biomarker for colorectal carcinoma based on proteomics technology. Int. J. Oncol. 2010, 37:355-365.
24. Tjalsma H. Identification of biomarkers for colorectal cancer through proteomics-based approaches. Expert Rev. Proteomics 2010, 7:879-895.