MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 47, 2013, Pages 18946-18951

  Perdomo, Catalina ^a   Campbell, Joshua D ^a,b   Gerrein, Joseph ^a,b   Tellez, Carmen S ^c   Garrison, Carly B ^a   Walser, Tonya C ^d   Drizik, Eduard ^a   Si, Huiqing ^a   Gower, Adam C ^a,b   Vick, Jessica ^a   Anderlind, Christina ^a   Jackson, George R ^e   Mankus, Courtney ^e   Schembri, Frank ^a   O'Hara, Carl ^a   Gomperts, Brigitte N ^d   Dubinett, Steven M ^d   Hayden, Patrick ^e   Belinsky, Steven A ^c   Lenburg, Marc E ^a,b   Spira, Avrum ^a,b   more..

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY   (United States)

^c LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e MATTEK CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGONAUTE PROTEIN; BETA TUBULIN; DICER; MICRORNA; MICRORNA 4423; MUCIN 5AC; MUCIN 5B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CANCER GROWTH; CELL DIFFERENTIATION; CILIATED EPITHELIUM; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LUNG CANCER; LUNG CARCINOGENESIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AIRWAY EPITHELIUM DEVELOPMENT; MICRORNA DISCOVERY; NEXT-GENERATION SEQUENCING TECHNOLOGY; NONCODING RNA; TUMOR SUPPRESSOR;

ANIMALS; CARCINOGENESIS; CELL DIFFERENTIATION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG NEOPLASMS; MICE; MICROARRAY ANALYSIS; MICRORNAS; REAL-TIME POLYMERASE CHAIN REACTION; RESPIRATORY MUCOSA; TUMOR MARKERS, BIOLOGICAL;

EID: 84888107536     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1220319110     Document Type: Article

References (40)

1. Hwang HW, Mendell JT (2006) MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 94(6-776-780.
2. Zhao Y, Srivastava D (2007) A developmental view of microRNA function. Trends Biochem Sci 32(4-189-197.
3. Lizé M, Herr C, Klimke A, Bals R, Dobbelstein M (2010) MicroRNA-449a levels increase by several orders of magnitude during mucociliary differentiation of airway epithelia. Cell Cycle 9(22-4579-4583.
4. Marcet B, et al. (2011) Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway. Nat Cell Biol 13(6-693-699.
5. Fabbri M, et al. (2007) MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci USA 104(40-15805-15810.
6. Taulli R, et al. (2009) The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation. J Clin Invest 119(8-2366-2378.
7. Brase JC, Wuttig D, Kuner R, Sültmann H (2010) Serum microRNAs as non-invasive biomarkers for cancer. Mol Cancer 9:306.
8. Kosaka N, Iguchi H, Ochiya T (2010) Circulating microRNA in body fluid: A new potential biomarker for cancer diagnosis and prognosis. Cancer Sci 101(10-2087-2092.
9. Shields PG (2002) Molecular epidemiology of smoking and lung cancer. Oncogene 21(45-6870-6876.
10. Sridhar S, et al. (2008) Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium. BMC Genomics 9:259.
11. Zhang X, et al. (2010) Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium. Physiol Genomics 41(1-1-8.
12. Beane J, et al. (2007) Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression. Genome Biol 8(9-R201.
13. Chari R, et al. (2007) Effect of active smoking on the human bronchial epithelium transcriptome. BMC Genomics 8:297.
14. Hackett NR, et al. (2003) Variability of antioxidant-related gene expression in the airway epithelium of cigarette smokers. Am J Respir Cell Mol Biol 29(3 Pt 1-331-343.
15. Spira A, et al. (2004) Effects of cigarette smoke on the human airway epithelial cell transcriptome. Proc Natl Acad Sci USA 101(27-10143-10148.
16. Schembri F, et al. (2009) MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc Natl Acad Sci USA 106(7- 2319-2324.
17. Spira A, et al. (2007) Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nat Med 13(3-361-366.
18. Langmead B, Trapnell C, Pop M, Salzberg SL (2009) Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol 10(3-R25.
19. Griffiths-Jones S (2004) The microRNA Registry. Nucleic Acids Res 32(Database issue- D109-D111.
20. Friedländer MR, et al. (2008) Discovering microRNAs from deep sequencing data using miRDeep. Nat Biotechnol 26(4-407-415.
21. Stark MS, et al. (2010) Characterization of the melanoma miRNAome by deep sequencing. PLoS ONE 5(3-e9685.
22. Witten D, Tibshirani R, Gu SG, Fire A, Lui WO (2010) Ultra-high throughput sequencing- based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls. BMC Biol 8:58.
23. Hafner M, et al. (2010) Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell 141(1-129-141.
24. Yang P, Sale WS (1998) The Mr 140,000 intermediate chain of Chlamydomonas flagellar inner arm dynein is a WD-repeat protein implicated in dynein arm anchoring. Mol Biol Cell 9(12-3335-3349.
25. Lonergan KM, et al. (2006) Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression. Am J Respir Cell Mol Biol 35(6-651-661.
26. Deus HF, et al. (2010) Exposing The Cancer Genome Atlas as a SPARQL endpoint. J Biomed Inform 43(6-998-1008.
27. Asnaghi L, et al. (2010) E-cadherin negatively regulates neoplastic growth in nonsmall cell lung cancer: Role of Rho GTPases. Oncogene 29(19-2760-2771.
28. Bremnes RM, Veve R, Hirsch FR, Franklin WA (2002) The E-cadherin cell-cell adhesion complex and lung cancer invasion, metastasis, and prognosis. Lung Cancer 36(2- 115-124.
29. Grimson A, et al. (2007) MicroRNA targeting specificity in mammals: Determinants beyond seed pairing. Mol Cell 27(1-91-105.
30. Enright AJ, et al. (2003) MicroRNA targets in Drosophila. Genome Biol 5(1-R1.
31. Wang L, et al. (2013) miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development 140(13-2755-2764.
32. Khaleque MA, et al. (2005) Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth. Oncogene 24(43- 6564-6573.
33. Akca H, Demiray A, Tokgun O, Yokota J (2011) Invasiveness and anchorage independent growth ability augmented by PTEN inactivation through the PI3K/AKT/ NFkB pathway in lung cancer cells. Lung Cancer 73(3-302-309.
34. Carrano AC, Pagano M (2001) Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression. J Cell Biol 153(7-1381-1390.
35. Ross AJ, Dailey LA, Brighton LE, Devlin RB (2007) Transcriptional profiling of mucociliary differentiation in human airway epithelial cells. Am J Respir Cell Mol Biol 37(2- 169-185.
36. Sanchez-Palencia A, et al. (2011) Gene expression profiling reveals novel biomarkers in nonsmall cell lung cancer. Int J Cancer 129(2-355-364.
37. Xi L, et al. (2008) Whole genome exon arrays identify differential expression of alternatively spliced, cancer-related genes in lung cancer. Nucleic Acids Res 36(20- 6535-6547.
38. Wachi S, Yoneda K, Wu R (2005) Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues. Bioinformatics 21(23-4205-4208.
39. Sell S (1993) Cellular origin of cancer: Dedifferentiation or stem cell maturation arrest? Environ Health Perspect 101(Suppl 5-15-26.
40. Gustafson AM, et al. (2010) Airway PI3K pathway activation is an early and reversible event in lung cancer development. Sci Transl Med 2(26-26ra25.