MDR-1 genotypes and quetiapine pharmacokinetics in healthy volunteers

Drug Metabolism and Drug Interactions

Volumn 28, Issue 3, 2013, Pages 163-166

  González Vacarezza, Nicolás ^a   Dorado, Pedro ^a   Peñas Lledó, Eva M ^a   Fariñas, Humberto ^a   Estévez Carrizo, Francisco E ^b   LLerena, Adrián ^a,c  

^a UNIVERSITY OF EXTREMADURA   (Spain)

^b Italian Hospital   (Uruguay)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

Author keywords

MDR 1; P glycoprotein; Pharmacokinetic; Quetiapine

Indexed keywords

MULTIDRUG RESISTANCE PROTEIN 1; QUETIAPINE;

ALLELE; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CAUCASIAN; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HOMOZYGOSITY; HUMAN; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; OPEN STUDY; PLASMA CONCENTRATION-TIME CURVE; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; SINGLE NUCLEOTIDE POLYMORPHISM; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANTIPSYCHOTIC AGENTS; DIBENZOTHIAZEPINES; FEMALE; HEALTHY VOLUNTEERS; HUMANS; MALE; P-GLYCOPROTEIN; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84888104582     PISSN: 07925077     EISSN: None     Source Type: Journal    
DOI: 10.1515/dmdi-2013-0008     Document Type: Article

References (14)

1. Zhou SF. Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition. Xenobiotica 2008;38: 802-32.
2. Hodges LM, Markova SM, Chinn LW, Gow JM, Kroetz DL, Klein TE, et al. Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein). Pharmacogenet Genomics 2011;21: 152-61.
3. Leschziner GD, Andrew T, Pirmohamed M, Johnson MR. ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research. Pharmacogenomics J 2007;7: 154-79. (Pubitemid 46794925)
4. Boulton DW, DeVane CL, Liston HL, Markowitz JS. In vitro P-glycoprotein affinity for atypical and conventional antipsychotics. Life Sci 2002;71: 163-9. (Pubitemid 34595435)
5. Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, et al. Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther 2002;303: 1029-37. (Pubitemid 35424386)
6. Grimm SW, Richtand NM, Winter HR, Stams KR, Reele SB. Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics. Br J Clin Pharmacol 2006;61: 58-69. (Pubitemid 43381238)
7. Nikisch G, Baumann P, Oneda B, Kiessling B, Weisser H, Mathé AA, et al. Cytochrome P450 and ABCB1 genetics: association with quetiapine and norquetiapine plasma and cerebrospinal fluid concentrations and with clinical response in patients suffering from schizophrenia. A pilot study. J Psychopharmacol 2011;25: 896-907.
8. Rahi M, Heikkinen T, Härtter S, Hakkola J, Hakala K, Wallerman O, et al. Placental transfer of quetiapine in relation to P-glycoprotein activity. J Psychopharmacol 2007;21: 751-6. (Pubitemid 47437915)
9. Estevez-Carrizo FE, Parrillo S, Ercoli MC, Estevez-Parrillo FT. Single-dose relative bioavailability of a new quetiapine fumarate extended-release formulation: a postprandial, randomized, open-label, two-period crossover study in healthy Uruguayan volunteers. Clin Ther 2011;33: 738-45.
10. The Pharmacogenomics Knowledgebase (PharmGKB). Available at: http://www.pharmgkb.org. Accessed 29 November 2012.
11. Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmöller J, Johne A, et al. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 2000;97: 3473-8. (Pubitemid 30183327)
12. Sandanaraj E, Lal S, Selvarajan V, Ooi LL, Wong ZW, Wong NS, et al. PXR pharmacogenetics: association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients. Clin Cancer Res 2008;14: 7116-26.
13. Perloff MD, von Moltke LL, Störmer E, Shader RI, Greenblatt DJ. Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure. Br J Pharmacol 2001;134: 1601-8. (Pubitemid 34038092)
14. Chalise P, Batzler A, Abo R, Wang L, Fridley BL. Simultaneous analysis of multiple data types in pharmacogenomic studies using weighted sparse canonical correlation analysis. OMICS 2012;16: 363-73.