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Volumn 19, Issue 22, 2013, Pages 6084-6088

Molecular pathways: Induction of polyploidy as a novel differentiation therapy for leukemia

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; ALISERTIB; ANTINEOPLASTIC AGENT; DIMETHYLFASUDIL; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 84888093257     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-12-2604     Document Type: Article
Times cited : (27)

References (49)
  • 1
    • 34648833029 scopus 로고    scopus 로고
    • Delivering new insight into the biology of megakaryopoiesis and thrombopoiesis
    • DOI 10.1097/MOH.0b013e3282bad151, PII 0006275220070900000002
    • Battinelli EM, Hartwig JH, Italiano JE Jr. Delivering new insight into the biology of megakaryopoiesis and thrombopoiesis. Curr Opin Hematol 2007;14:419-26. (Pubitemid 47457630)
    • (2007) Current Opinion in Hematology , vol.14 , Issue.5 , pp. 419-426
    • Battinelli, E.M.1    Hartwig, J.H.2    Italiano Jr., J.E.3
  • 4
    • 33644858630 scopus 로고    scopus 로고
    • Rho GTPases in animal cell mitosis
    • DOI 10.1016/j.ceb.2006.02.002, PII S0955067406000160, Cell Regulation
    • Narumiya S, Yasuda S. Rho GTPases in animal cell mitosis. Curr Opin Cell Biol 2006;18:199-205. (Pubitemid 43375889)
    • (2006) Current Opinion in Cell Biology , vol.18 , Issue.2 , pp. 199-205
    • Narumiya, S.1    Yasuda, S.2
  • 5
    • 22244473991 scopus 로고    scopus 로고
    • A microtubule-dependent zone of active RhoA during cleavage plane specification
    • DOI 10.1083/jcb.200501131
    • Bement WM, Benink HA, von Dassow G. A microtubule-dependent zone of active RhoA during cleavage plane specification. J Cell Biol 2005;170:91-101. (Pubitemid 40994099)
    • (2005) Journal of Cell Biology , vol.170 , Issue.1 , pp. 91-101
    • Bement, W.M.1    Benink, H.A.2    Von Dassow, G.3
  • 7
    • 0032583123 scopus 로고    scopus 로고
    • Roles of Rho-associated kinase in cytokinesis; mutations in Rho- associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments
    • DOI 10.1083/jcb.143.5.1249
    • Yasui Y, Amano M, Nagata K, Inagaki N, Nakamura H, Saya H, et al. Roles of Rho-associated kinase in cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments. J Cell Biol 1998;143:1249-58. (Pubitemid 28559826)
    • (1998) Journal of Cell Biology , vol.143 , Issue.5 , pp. 1249-1258
    • Yasui, Y.1    Amano, M.2    Nagata, K.-I.3    Inagaki, N.4    Nakamura, H.5    Saya, H.6    Kaibuchi, K.7    Inagaki, M.8
  • 8
    • 0033614371 scopus 로고    scopus 로고
    • Specific accumulation of Rho-associated kinase at the cleavage furrow during cytokinesis: Cleavage furrow-specific phosphorylation of intermediate filaments
    • DOI 10.1038/sj.onc.1202633
    • Kosako H, Goto H, Yanagida M, Matsuzawa K, Fujita M, Tomono Y, et al. Specific accumulation of Rho-associated kinase at the cleavage furrow during cytokinesis: cleavage furrow-specific phosphorylation of intermediate filaments. Oncogene 1999;18:2783-8. (Pubitemid 29237668)
    • (1999) Oncogene , vol.18 , Issue.17 , pp. 2783-2788
    • Kosako, H.1    Goto, H.2    Yanagida, M.3    Matsuzawa, K.4    Fujita, M.5    Tomono, Y.6    Okigaki, T.7    Odai, H.8    Kaibuchi, K.9    Inagaki, M.10
  • 9
    • 0034619765 scopus 로고    scopus 로고
    • Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow
    • DOI 10.1038/sj.onc.1203987
    • Kosako H, Yoshida T, Matsumura F, Ishizaki T, Narumiya S, Inagaki M. Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow. Oncogene 2000;19:6059-64. (Pubitemid 32039380)
    • (2000) Oncogene , vol.19 , Issue.52 , pp. 6059-6064
    • Kosako, H.1    Yoshida, T.2    Matsumura, F.3    Ishizaki, T.4    Narumiya, S.5    Inagaki, M.6
  • 10
    • 0037195254 scopus 로고    scopus 로고
    • Rho1 directs formin-mediated actin ring assembly during budding yeast cytokinesis
    • DOI 10.1016/S0960-9822(02)01238-1, PII S0960982202012381
    • Tolliday N, Ver Plank L, Li R. Rho1 directs formin-mediated actin ring assembly during budding yeast cytokinesis. Curr Biol 2002;12:1864-70. (Pubitemid 35273908)
    • (2002) Current Biology , vol.12 , Issue.21 , pp. 1864-1870
    • Tolliday, N.1    VerPlank, L.2    Li, R.3
  • 11
    • 48849098702 scopus 로고    scopus 로고
    • Direct visualization of the endomitotic cell cycle in living megakaryocytes: Differential patterns in low and high ploidy cells
    • Papadantonakis N, Makitalo M, McCrann DJ, Liu K, Nguyen HG, Martin G, et al. Direct visualization of the endomitotic cell cycle in living megakaryocytes: differential patterns in low and high ploidy cells. Cell Cycle 2008;7:2352-6.
    • (2008) Cell Cycle , vol.7 , pp. 2352-2356
    • Papadantonakis, N.1    Makitalo, M.2    McCrann, D.J.3    Liu, K.4    Nguyen, H.G.5    Martin, G.6
  • 12
    • 54049128933 scopus 로고    scopus 로고
    • Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling
    • Lordier L, Jalil A, Aurade F, Larbret F, Larghero J, Debili N, et al. Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling. Blood 2008;112:3164-74.
    • (2008) Blood , vol.112 , pp. 3164-3174
    • Lordier, L.1    Jalil, A.2    Aurade, F.3    Larbret, F.4    Larghero, J.5    Debili, N.6
  • 13
    • 33847775619 scopus 로고    scopus 로고
    • Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression
    • Geddis AE, Fox NE, Tkachenko E, Kaushansky K. Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression. Cell Cycle 2007;6:455-60. (Pubitemid 46393450)
    • (2007) Cell Cycle , vol.6 , Issue.4 , pp. 455-460
    • Geddis, A.E.1    Fox, N.E.2    Tkachenko, E.3    Kaushansky, K.4
  • 15
    • 33644749305 scopus 로고    scopus 로고
    • Endomitotic megakaryocytes form a midzone in anaphase but have a deficiency in cleavage furrow formation
    • Geddis AE, Kaushansky K. Endomitotic megakaryocytes form a midzone in anaphase but have a deficiency in cleavage furrow formation. Cell Cycle 2006;5:538-45. (Pubitemid 43340533)
    • (2006) Cell Cycle , vol.5 , Issue.5 , pp. 538-545
    • Geddis, A.E.1    Kaushansky, K.2
  • 16
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • DOI 10.1038/nature01148
    • Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature 2002;420:629-35. (Pubitemid 36764489)
    • (2002) Nature , vol.420 , Issue.6916 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 17
    • 13444252631 scopus 로고    scopus 로고
    • GEF means go: Turning on Rho GTPases with guanine nucleotide-exchange factors
    • DOI 10.1038/nrm1587
    • Rossman KL, der CJ, Sondek J. GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 2005;6:167-80. (Pubitemid 40215811)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.2 , pp. 167-180
    • Rossman, K.L.1    Der, C.J.2    Sondek, J.3
  • 18
    • 34247611900 scopus 로고    scopus 로고
    • Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the rhogef ect2 to the central spindle
    • DOI 10.1016/j.devcel.2007.03.013, PII S153458070700113X
    • Petronczki M, Glotzer M, Kraut N, Peters JM. Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. Dev Cell 2007;12:713-25. (Pubitemid 46667747)
    • (2007) Developmental Cell , vol.12 , Issue.5 , pp. 713-725
    • Petronczki, M.1    Glotzer, M.2    Kraut, N.3    Peters, J.-M.4
  • 19
    • 23944499922 scopus 로고    scopus 로고
    • An ECT2-centralspindlin complex regulates the localization and function of RhoA
    • DOI 10.1083/jcb.200501097
    • Yuce O, Piekny A, Glotzer M. An ECT2-centralspindlin complex regulates the localization and function of RhoA. J Cell Biol 2005;170:571-82. (Pubitemid 41186932)
    • (2005) Journal of Cell Biology , vol.170 , Issue.4 , pp. 571-582
    • Yuce, O.1    Piekny, A.2    Glotzer, M.3
  • 20
    • 77955299128 scopus 로고    scopus 로고
    • The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer
    • Fields AP, Justilien V. The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer. Adv Enzyme Regul 2010;50:190-200.
    • (2010) Adv Enzyme Regul , vol.50 , pp. 190-200
    • Fields, A.P.1    Justilien, V.2
  • 22
    • 34247615185 scopus 로고    scopus 로고
    • GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases
    • DOI 10.1016/j.devcel.2007.03.014, PII S1534580707001141
    • Birkenfeld J, Nalbant P, Bohl BP, Pertz O, Hahn KM, Bokoch GM. GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev Cell 2007;12:699-712. (Pubitemid 46671149)
    • (2007) Developmental Cell , vol.12 , Issue.5 , pp. 699-712
    • Birkenfeld, J.1    Nalbant, P.2    Bohl, B.P.3    Pertz, O.4    Hahn, K.M.5    Bokoch, G.M.6
  • 23
    • 0033561797 scopus 로고    scopus 로고
    • Deconstructing a disease: RARα, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia
    • Melnick A, Licht JD. Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 1999;93:3167-215. (Pubitemid 29220886)
    • (1999) Blood , vol.93 , Issue.10 , pp. 3167-3215
    • Melnick, A.1    Licht, J.D.2
  • 24
    • 18544379794 scopus 로고    scopus 로고
    • Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656
    • DOI 10.1182/blood-2004-10-3934
    • Lannutti BJ, Blake N, Gandhi MJ, Reems JA, Drachman JG. Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656. Blood 2005;105:3875-8. (Pubitemid 40656131)
    • (2005) Blood , vol.105 , Issue.10 , pp. 3875-3878
    • Lannutti, B.J.1    Blake, N.2    Gandhi, M.J.3    Reems, J.A.4    Drachman, J.G.5
  • 25
    • 84864621502 scopus 로고    scopus 로고
    • Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL
    • Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, et al. Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL. Cell 2012;150:575-89.
    • (2012) Cell , vol.150 , pp. 575-589
    • Wen, Q.1    Goldenson, B.2    Silver, S.J.3    Schenone, M.4    Dancik, V.5    Huang, Z.6
  • 26
    • 84055217855 scopus 로고    scopus 로고
    • Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays
    • Manfredi MG, Ecsedy JA, Chakravarty A, Silverman L, Zhang M, Hoar KM, et al. Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays. Clin Cancer Res 2011;17:7614-24.
    • (2011) Clin Cancer Res , vol.17 , pp. 7614-7624
    • Manfredi, M.G.1    Ecsedy, J.A.2    Chakravarty, A.3    Silverman, L.4    Zhang, M.5    Hoar, K.M.6
  • 27
    • 84870256595 scopus 로고    scopus 로고
    • Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models
    • Thiollier C, Lopez CK, Gerby B, Ignacimouttou C, Poglio S, Duffourd Y, et al. Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models. J Exp Med 2012;209:2017-31.
    • (2012) J Exp Med , vol.209 , pp. 2017-2031
    • Thiollier, C.1    Lopez, C.K.2    Gerby, B.3    Ignacimouttou, C.4    Poglio, S.5    Duffourd, Y.6
  • 28
    • 0033780541 scopus 로고    scopus 로고
    • The management of neoplastic disorders of haematopoiesis in children with Down's syndrome
    • Lange B. The management of neoplastic disorders of haematopoiesis in children with Down's syndrome. Br J Haematol 2000;110:512-24.
    • (2000) Br J Haematol , vol.110 , pp. 512-524
    • Lange, B.1
  • 29
    • 0023459992 scopus 로고
    • Megakaryoblastic leukemia and Down's syndrome: A review
    • Zipursky A, Peeters M, Poon A. Megakaryoblastic leukemia and Down's syndrome: a review. Pediatr Hematol Oncol 1987;4:211-30.
    • (1987) Pediatr Hematol Oncol , vol.4 , pp. 211-230
    • Zipursky, A.1    Peeters, M.2    Poon, A.3
  • 31
    • 0026654207 scopus 로고
    • The translocation t (1;22) (p13;q13) is a nonrandom marker specifically associated with acute megakaryocytic leukemia in young children
    • Lion T, Haas OA, Harbott J, Bannier E, Ritterbach J, Jankovic M, et al. The translocation t (1;22) (p13;q13) is a nonrandom marker specifically associated with acute megakaryocytic leukemia in young children. Blood 1992;79:3325-30.
    • (1992) Blood , vol.79 , pp. 3325-3330
    • Lion, T.1    Haas, O.A.2    Harbott, J.3    Bannier, E.4    Ritterbach, J.5    Jankovic, M.6
  • 34
    • 84869009858 scopus 로고    scopus 로고
    • An Inv (16) (p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia
    • Gruber TA, Larson Gedman A, Zhang J, Koss CS, Marada S, Ta HQ, et al. An Inv (16) (p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. Cancer Cell 2012;22:683-97.
    • (2012) Cancer Cell , vol.22 , pp. 683-697
    • Gruber, T.A.1    Gedman, A.L.2    Zhang, J.3    Koss, C.S.4    Marada, S.5    Ta, H.Q.6
  • 35
    • 84890434451 scopus 로고    scopus 로고
    • NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern
    • Mar. 27. Epub ahead of print
    • de Rooij JD, Hollink IH, Arentsen-Peters ST, van Galen JF, Berna Beverloo H, Baruchel A, et al. NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern. Leukemia. 2013 Mar. 27. [Epub ahead of print].
    • (2013) Leukemia
    • De Rooij, J.D.1    Hollink, I.H.2    Arentsen-Peters, S.T.3    Van Galen, J.F.4    Beverloo, H.B.5    Baruchel, A.6
  • 39
    • 84866492297 scopus 로고    scopus 로고
    • Favorable survival maintained in children who have myeloid leukemia associated with Down syndrome using reduced-dose chemotherapy on Children's Oncology Group trial A2971: A report from the Children's Oncology Group
    • Sorrell AD, Alonzo TA, Hilden JM, Gerbing RB, Loew TW, Hathaway L, et al. Favorable survival maintained in children who have myeloid leukemia associated with Down syndrome using reduced-dose chemotherapy on Children's Oncology Group trial A2971: a report from the Children's Oncology Group. Cancer 2012;118:4806-14.
    • (2012) Cancer , vol.118 , pp. 4806-4814
    • Sorrell, A.D.1    Alonzo, T.A.2    Hilden, J.M.3    Gerbing, R.B.4    Loew, T.W.5    Hathaway, L.6
  • 41
    • 84875224988 scopus 로고    scopus 로고
    • Prognostic features in acute megakaryoblastic leukemia in children without Down syndrome: A report from the AML02 multicenter trial and the Children's Oncology Group Study POG 9421
    • O'Brien MM, Cao X, Pounds S, Dahl GV, Raimondi SC, Lacayo NJ, et al. Prognostic features in acute megakaryoblastic leukemia in children without Down syndrome: a report from the AML02 multicenter trial and the Children's Oncology Group Study POG 9421. Leukemia 2013;27:731-4.
    • (2013) Leukemia , vol.27 , pp. 731-734
    • O'Brien, M.M.1    Cao, X.2    Pounds, S.3    Dahl, G.V.4    Raimondi, S.C.5    Lacayo, N.J.6
  • 43
    • 34249821646 scopus 로고    scopus 로고
    • Comparison of childhood myelodysplastic syndrome, AML FAB M6 or M7, CCG 2891: Report from the Children's Oncology Group
    • DOI 10.1002/pbc.20951
    • Barnard DR, Alonzo TA, Gerbing RB, Lange B, Woods WG. Comparison of childhood myelodysplastic syndrome, AML FAB M6 or M7, CCG 2891: Report from the Children's Oncology Group. Pediatr Blood Cancer 2007;49:17-22. (Pubitemid 46850650)
    • (2007) Pediatric Blood and Cancer , vol.49 , Issue.1 , pp. 17-22
    • Barnard, D.R.1    Alonzo, T.A.2    Gerbing, R.B.3    Lange, B.4    Woods, W.G.5
  • 44
    • 0035878006 scopus 로고    scopus 로고
    • Biology and outcome of childhood acute megakaryoblastic leukemia: A single institution's experience
    • Athale UH, Razzouk BI, Raimondi SC, Tong X, Behm FG, Head DR, et al. Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience. Blood 2001;97:3727-32.
    • (2001) Blood , vol.97 , pp. 3727-3732
    • Athale, U.H.1    Razzouk, B.I.2    Raimondi, S.C.3    Tong, X.4    Behm, F.G.5    Head, D.R.6
  • 47
    • 81155124082 scopus 로고    scopus 로고
    • Phase 2 study of MLN8237, an investigational aurora A kinase (AAK) inhibitor in patients with acute myelogenous leukemia (AML) or myelodysplastic syndromes (MDS)
    • abstracts
    • Goldberg SL, Fenaux P, Craig MD, Gyan E, Lister J, Kassis J, et al. Phase 2 study of MLN8237, an investigational aurora A kinase (AAK) inhibitor in patients with acute myelogenous leukemia (AML) or myelodysplastic syndromes (MDS). Blood ASH Annual Meeting abstracts 2010;116:3273.
    • (2010) Blood ASH Annual Meeting , vol.116 , pp. 3273
    • Goldberg, S.L.1    Fenaux, P.2    Craig, M.D.3    Gyan, E.4    Lister, J.5    Kassis, J.6
  • 48
    • 77954686021 scopus 로고    scopus 로고
    • A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma
    • Gorgun G, Calabrese E, Hideshima T, Ecsedy J, Perrone G, Mani M, et al. A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma. Blood 2010;115:5202-13.
    • (2010) Blood , vol.115 , pp. 5202-5213
    • Gorgun, G.1    Calabrese, E.2    Hideshima, T.3    Ecsedy, J.4    Perrone, G.5    Mani, M.6
  • 49
    • 84859405151 scopus 로고    scopus 로고
    • The aurora kinase A inhibitor MLN8237 enhances cisplatininduced cell death in esophageal adenocarcinoma cells
    • Sehdev V, Peng D, Soutto M, Washington MK, Revetta F, Ecsedy J, et al. The aurora kinase A inhibitor MLN8237 enhances cisplatininduced cell death in esophageal adenocarcinoma cells. Mol Cancer Ther 2012;11:763-74.
    • (2012) Mol Cancer Ther , vol.11 , pp. 763-774
    • Sehdev, V.1    Peng, D.2    Soutto, M.3    Washington, M.K.4    Revetta, F.5    Ecsedy, J.6


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