The effect and mechanism of CXCR4 silencing on metastasis suppression of human glioma U87 cell line

Anatomical Record

Volumn 296, Issue 12, 2013, Pages 1857-1864

  Zhu, Yu ^a,b   Yang, Ping ^a,b   Zhang, Xuebin ^a,b   Zhang, Ling ^a,b   Cui, Guiping ^a,b   Wang, Qin ^a,b   Lv, Lixia ^a,b   Zhang, Yi ^a,b   Xin, Xin ^a,b   Yan, Tao ^a,b   Zhao, Meng ^c   Zhang, Nan ^d  

^a TIANJIN HUANHU HOSPITAL   (China)

^b Tianjin Key Laboratory of Cerebral Vessels and Neural Degeneration   (China)

^c TIANJIN MEDICAL UNIVERSITY   (China)

^d TIANJIN CHILDREN S HOSPITAL   (China)

Author keywords

CXCR4; Glioma; Tumor metastasis

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; GELATINASE A; GELATINASE B; HERMES ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN;

ARTICLE; CANCER INHIBITION; CANCER PROGNOSIS; CELL ADHESION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL INVASION; CELL LINE U87; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; GLIOMA; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE; WESTERN BLOTTING;

CXCR4; GLIOMA; TUMOR METASTASIS;

APOPTOSIS; BLOTTING, WESTERN; CADHERINS; CELL ADHESION; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; MATRIX METALLOPROTEINASE 2; NEOPLASM METASTASIS; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84888068698     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.22825     Document Type: Article

References (17)

1. Bajetto A, Barbieri F, Dorcaratto A, Barbero S, Daga A, Porcile C, Ravetti JL, Zona G, Spaziante R, Corte G, et al. 2006. Expression of CXC chemokine receptors 1-5 and their ligands in human glioma issues: role of CXCR4 and SDF1 in glioma cell proliferation and migration. Neurochem Int 5:423-432.
2. Chaudary N, Mujcic H, Wouters BG, Hill RP. 2013. Hypoxia and metastasis in an orthotopic cervix cancer xenograft model. Radiother Oncol S0167-8140:298-293.
3. Faber A, Hoermann K, Stern-Straeter J, Schultz DJ, Goessler UR. 2013. Functional effects of SDF-1α on a CD44(+) CXCR4(+) squamous cell carcinoma cell line as a model for interactions in the cancer stem cell niche. Oncol Rep 29:579-584.
4. Gil M, Seshadri M, Komorowski MP, Abrams SI, Kozbor D. 2013. Targeting CXCL12/CXCR4 signaling with oncolytic virotherapy disrupts tumor vasculature and inhibits breast cancer metastases. Proc Natl Acad Sci USA 110:E1291-E1300.
5. Gillies K, Wertman J, Charette N, Dupré DJ. 2013. Anterograde trafficking of CXCR4 and CCR2 receptors in a prostate cancer cell line. Cell Physiol Biochem 32:74-85.
6. Guo G, Kuai D, Cai S, Xue N, Liu Y, Hao J, Fan Y, Jin J, Mao X, Liu B, et al. 2013.Knockdown of FRAT1 expression by RNA interference inhibits human glioblastoma cell growth, migration and invasion. PLoS One 8:e61206.
7. Hu T, Yao Y, Yu S, Guo H, Han L, Wang W, Tian T, Hao Y, Liu Z, Nan K, et al. 2013. Clinicopathologic significance of CXCR4 and Nrf2 in colorectal cancer. J Biomed Res 27:283-290.
8. Huang Z, Meng S, Wang L, Wang Y, Chen T, Wang C. 2012. Suppression of oxLDL-induced MMP-9 and EMMPRIN expression by berberine via inhibition of NF-κB activation in human THP-1 macrophages. Anat Rec (Hoboken) 295:78-86.
9. Li X, Ling N, Bai Y, Dong W, Hui GZ, Liu D, Zhao J, Hu J. 2013. MiR-16-1 plays a role in reducing migration and invasion of glioma cells. Anat Rec (Hoboken) 296:427-432.
10. Munson JM, Bellamkonda RV, Swartz MA. 2013. Interstitial flow in a 3D microenvironment increases glioma invasion by a CXCR4-dependent mechanism. Cancer Res 73:1536-1546.
11. Shahar T, Nossek E, Steinberg DM, Rozovski U, Blumenthal DT, Bokstein F, Sitt R, Freedman S, Corn BW, Kanner AA, et al. 2012. The impact of enrollment in clinical trials on survival of patients with glioblastoma. J Clin Neurosci 19:1530-1534.
12. Shiota M, Song Y, Yokomizo A, Kiyoshima K, Tada Y, Uchino H, Uchiumi T, Inokuchi J, Oda Y, Kuroiwa K, et al. 2010. Foxo3a suppression of urothelial cancer invasiveness through Twist1, Y-box-binding protein 1, and E-cadherin regulation. Clin Cancer Res 16:5654-5663.
13. Wang H, Liu W, Jin J, Zhou L, Liang L, Guo Y. 2013. M-ds-P21 induces cell apoptosis in bladder cancer T24 cells through P53 independent pathway. J Cancer Res Ther 1:54-59.
14. Wang T, Mi Y, Pian L, Gao P, Xu H, Zheng Y, Xuan X. 2013. RNAi targeting CXCR4 inhibits proliferation and invasion of esophageal carcinoma cells. Diagn Pathol 8:104.
15. Wang WS, Yu SL, Yang XS, Chang SD, Hou JQ. 2013. Expression and significance of twist and E-cadherin in ovarian cancer tissues. Asian Pac J Cancer Prev 14:669-672.
16. Wu W, Yang J, Feng X, Wang H, Ye S, Yang P, Tan W, Wei G, Zhou Y. 2013. MicroRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cells. Mol Cancer 12:30.
17. Xiong B, Cheng Y, Ma L, Zhang C. 2013. MiR-21 regulates biological behavior through the PTEN/PI-3K/AKT signaling pathway in human colorectal cancer cells. Int J Oncol 1:219-228.