Emergence of a distinct HIV-specific IL-10-producing CD8+ T-cell subset with immunomodulatory functions during chronic HIV-1 infection

European Journal of Immunology

Volumn 43, Issue 11, 2013, Pages 2875-2885

  Clutton, Genevieve ^a   Yang, Hongbing ^a   Hancock, Gemma ^a   Sande, Nellia ^b   Holloway, Cameron ^c   Angus, Brian ^a   von Delft, Annette ^d   Barnes, Eleanor ^d   Borrow, Persephone ^e   Pellegrino, Pierre ^f   Williams, Ian ^f   Mcmichael, Andrew ^a   Dorrell, Lucy ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

CD8+ T cell; Cellular immunity; Immune activation; Interleukin 10 (IL 10); Monocyte

Indexed keywords

ANTIRETROVIRUS AGENT; CD14 ANTIGEN; CD38 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRANSCRIPTION FACTOR FOXP3;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CD8+ T LYMPHOCYTE; CELL LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOMODULATION; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; STIMULATION; T CELL DEPLETION; T LYMPHOCYTE SUBPOPULATION; UPREGULATION; VIREMIA;

CD8+ T CELL; CELLULAR IMMUNITY; IMMUNE ACTIVATION; INTERLEUKIN-10 (IL-10); MONOCYTE;

ADULT; ANTIGENS, CD14; ANTIGENS, CD38; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV INFECTIONS; HIV-1; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-6; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; UP-REGULATION; VIRAL LOAD;

EID: 84888065550     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201343646     Document Type: Article

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