Treatment response of airway clearance assessed by single-breath washout in children with cystic fibrosis

Journal of Cystic Fibrosis

Volumn 12, Issue 6, 2013, Pages 567-574

  Abbas, Chiara ^a   Singer, Florian ^a   Yammine, Sophie ^a   Casaulta, Carmen ^a   Latzin, Philipp ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Children; Cystic fibrosis; Physical therapy modalities; Pulmonary ventilation; Respiratory function test

Indexed keywords

HELIUM; SULFUR HEXAFLUORIDE;

ADOLESCENT; ARTICLE; CAPNOMETRY; CHILD; CLINICAL ARTICLE; COMPUTER PROGRAM; CYSTIC FIBROSIS; DOUBLE TRACER GAS SINGLE BREATH GAS WASHOUT; EXPIRATORY FLOW; FEMALE; FORCED EXPIRATORY VOLUME; GAS EXCHANGE; GAS MIXING; HUMAN; LUNG CLEARANCE; LUNG FUNCTION; LUNG FUNCTION TEST; MALE; NITROGEN SINGLE BREATH GAS WASHOUT; PRESCHOOL CHILD; RESPIRATORY DIAGNOSTIC DEVICE; SCHOOL CHILD; SPIROMETRY; TIDAL VOLUME; TREATMENT RESPONSE; VITAL CAPACITY;

CARBON DIOXIDE; CF; CHEST PHYSIOTHERAPY; CHILDREN; CO(2); COEFFICIENT OF REPEATABILITY (BETWEEN-TEST REPEATABILITY); CR; CYSTIC FIBROSIS; DOUBLE-TRACER GAS: 26.3% HELIUM AND 5% SULFUR HEXAFLUORIDE; DTG; FEV(1); FORCED EXPIRATORY VOLUME IN ONE SECOND; HE; HELIUM; ICC; INTRA-CLASS CORRELATION COEFFICIENT (INTRA-TEST REPEATABILITY); LCI; LUNG CLEARANCE INDEX; MBW; MEAN EXPIRATORY FLOW BETWEEN 25 AND 75% OF EXPIRED VOLUME; MEF(25-75); MULTIPLE-BREATH WASHOUT TEST; N(2); NITROGEN; PFT; PHYSICAL THERAPY MODALITIES; PT; PULMONARY FUNCTION TEST; PULMONARY VENTILATION; RESPIRATORY FUNCTION TEST; SBW; SF(6); SIII; SINGLE-BREATH WASHOUT; SLOPE OF ALVEOLAR PHASE III FROM GAS WASHOUT CURVES; SNIII; SULFUR HEXAFLUORIDE; TIDAL VOLUME NORMALIZED PHASE III SLOPE FROM GAS WASHOUT CURVES;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CYSTIC FIBROSIS; FEMALE; HUMANS; MALE; PHYSICAL THERAPY MODALITIES; PULMONARY VENTILATION; RESPIRATORY FUNCTION TESTS;

EID: 84888047565     PISSN: 15691993     EISSN: 18735010     Source Type: Journal    
DOI: 10.1016/j.jcf.2013.05.010     Document Type: Article

References (40)

1. Elkins M.R., Robinson M., Rose B.R., et al. A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis. N Engl J Med 2006, 354:229-240.
2. Amin R., Subbarao P., Jabar A., et al. Hypertonic saline improves the LCI in paediatric patients with CF with normal lung function. Thorax 2010, 65:379-383.
3. Jaques A., Daviskas E., Turton J.A., et al. Inhaled mannitol improves lung function in cystic fibrosis. Chest 2008, 133:1388-1396.
4. Eng P.A., Morton J., Douglass J.A., Riedler J., Wilson J., Robertson C.F. Short-term efficacy of ultrasonically nebulized hypertonic saline in cystic fibrosis. Pediatr Pulmonol 1996, 21:77-83.
5. Gustafsson P.M., Aurora P., Lindblad A. Evaluation of ventilation maldistribution as an early indicator of lung disease in children with cystic fibrosis. Eur Respir J 2003, 22:972-979.
6. Horsley A.R., Gustafsson P.M., Macleod K.A., et al. Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis. Thorax 2008, 63:135-140.
7. Verbanck S., Paiva M., Paeps E., et al. Lung clearance index in adult CF patients: the role of convection-dependent lung units. Eur Respir J 2012, 10.1183/09031936.00125312.
8. Aurora P., Stanojevic S., Wade A., et al. Lung clearance index at 4years predicts subsequent lung function in children with cystic fibrosis. Am J Respir Crit Care Med 2011, 183:752-758.
9. Owens C.M., Aurora P., Stanojevic S., et al. Lung clearance index and HRCT are complementary markers of lung abnormalities in young children with CF. Thorax 2011, 66:481-488.
10. Amin R., Subbarao P., Lou W., et al. The effect of dornase alfa on ventilation Inhomogeneity in patients with cystic fibrosis. Eur Respir J 2011, 37:806-812.
11. Sontag M.K., Quittner A.L., Modi A.C., et al. Lessons learned from a randomized trial of airway secretion clearance techniques in cystic fibrosis. Pediatr Pulmonol 2010, 45:291-300.
12. van Winden C.M., Visser A., Hop W., Sterk P.J., Beckers S., De Jongste J.C. Effects of flutter and PEP mask physiotherapy on symptoms and lung function in children with cystic fibrosis. Eur Respir J 1998, 12:143-147.
13. App E.M., Kieselmann R., Reinhardt D., et al. Sputum rheology changes in cystic fibrosis lung disease following two different types of physiotherapy: flutter vs. autogenic drainage. Chest 1998, 114:171-177.
14. van der Schans C., Prasad A., Main E. Chest physiotherapy compared to no chest physiotherapy for cystic fibrosis. Cochrane Database Syst Rev 2000, CD001401.
15. Fuchs S.I., Toussaint S., Edlhaimb B., Ballmann M., Gappa M. Short-term effect of physiotherapy on variability of the lung clearance index in children with cystic fibrosis. Pediatr Pulmonol 2010, 45:301-306.
16. Singer F., Stern G., Thamrin C., et al. Tidal volume single breath washout of two tracer gases - a practical and promising lung function test. PLoS One 2011, 6:e17588.
17. Singer F., Stern G., Thamrin C., et al. A new double-tracer gas single-breath washout to assess early cystic fibrosis lung disease. Eur Respir J 2013, 41:339-345.
18. Stromberg N.O., Gustafsson P.M. Ventilation inhomogeneity assessed by nitrogen washout and ventilation-perfusion mismatch by capnography in stable and induced airway obstruction. Pediatr Pulmonol 2000, 29:94-102.
19. Fuchs S.I., Junge S., Ellemunter H., Ballmann M., Gappa M. Calculation of the capnographic index based on expiratory molar mass-volume-curves - a suitable tool to screen for cystic fibrosis lung disease. J Cyst Fibros 2013, 12:277-283.
20. Singer F., Kieninger E., Abbas C., et al. Practicability of nitrogen multiple-breath washout measurements in a pediatric cystic fibrosis outpatient setting. Pediatr Pulmonol 2012, 10.1002/ppul.22651.
21. Kieninger E., Singer F., Fuchs O., et al. Long-term course of lung clearance index between infancy and school-age in cystic fibrosis subjects. J Cyst Fibros 2011, 10:487-490.
22. Singer F., Houltz B., Latzin P., Robinson P., Gustafsson P. A realistic validation study of a new nitrogen multiple-breath washout system. PLoS One 2012, 7:e36083.
23. Robinson P.D., Latzin P., Verbanck S., et al. Consensus statement for inert gas washout measurement using multiple- and single-breath tests. Eur Respir J 2013, 41:507-522.
24. Horsley A.R., Macleod K.A., Robson A.G., et al. Effects of cystic fibrosis lung disease on gas mixing indices derived from alveolar slope analysis. Respir Physiol Neurobiol 2008, 162:197-203.
25. Robinson P.D., Goldman M.D., Gustafsson P.M. Inert gas washout: theoretical background and clinical utility in respiratory disease. Respiration 2009, 78:339-355.
26. in 't Veen J.C., Beekman A.J., Bel E.H., Sterk P.J. Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am J Respir Crit Care Med 2000, 161:1902-1906.
27. Crawford A.B., Makowska M., Paiva M., Engel L.A. Convection- and diffusion-dependent ventilation maldistribution in normal subjects. J Appl Physiol 1985, 59:838-846.
28. Beydon N., Davis S.D., Lombardi E., et al. An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children. Am J Respir Crit Care Med 2007, 175:1304-1345.
29. Stanojevic S., Wade A., Cole T.J., et al. Spirometry centile charts for young Caucasian children: the Asthma UK Collaborative Initiative. Am J Respir Crit Care Med 2009, 180:547-552.
30. Chinn S. Statistics in respiratory medicine. 2. Repeatability and method comparison. Thorax 1991, 46:454-456.
31. Bland J.M., Altman D.G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986, 1:307-310.
32. Stanbrook M.B., Corey M., Tullis D.E. The repeatability of forced expiratory volume measurements in adults with cystic fibrosis. Chest 2004, 125:150-155.
33. Rosenfeld M., Ratjen F., Brumback L., et al. Inhaled hypertonic saline in infants and children younger than 6years with cystic fibrosis: the ISIS randomized controlled trial. JAMA 2012, 307:2269-2277.
34. Paiva M. Gas transport in the human lung. J Appl Physiol 1973, 35:401-410.
35. Gustafsson P.M., Ljungberg H.K., Kjellman B. Peripheral airway involvement in asthma assessed by single-breath SF6 and He washout. Eur Respir J 2003, 21:1033-1039.
36. Bakker E.M., van der Meijden J.C., Nieuwhof E.M., Hop W.C., Tiddens H.A. Determining presence of lung disease in young children with cystic fibrosis: lung clearance index, oxygen saturation and cough frequency. J Cyst Fibros 2012, 11:223-230.
37. Verbanck S., Thompson B.R., Schuermans D., et al. Ventilation heterogeneity in the acinar and conductive zones of the normal ageing lung. Thorax 2012, 67:789-795.
38. Robinson P.D., Cooper P., Van A.P., Fitzgerald D., Selvadurai H. Using index of ventilation to assess response to treatment for acute pulmonary exacerbation in children with cystic fibrosis. Pediatr Pulmonol 2009, 44:733-742.
39. Price D., Musgrave S.D., Shepstone L., et al. Leukotriene antagonists as first-line or add-on asthma-controller therapy. N Engl J Med 2011, 364:1695-1707.
40. Yammine S., Singer F., Abbas C., Roos M., Latzin P. Multiple-breath washout measurements can be significantly shortened in children. Thorax Jun 2013, 68(6):586-587. (Electronic publication ahead of print 2012 Oct 31). 10.1136/thoraxjnl-2012-202345.