A new double-tracer gas single-breath washout to assess early cystic fibrosis lung disease

European Respiratory Journal

Volumn 41, Issue 2, 2013, Pages 339-345

  Singer, Florian ^a   Stern, Georgette ^a   Thamrin, Cindy ^a,c   Abbas, Chiara ^a   Casaulta, Carmen ^a   Frey, Urs ^a,b   Latzin, Philipp ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^c WOOLCOCK INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Children; Efficiency; Helium; Respiratory function tests; Small airway remodelling; Sulfur hexafluoride

Indexed keywords

HELIUM; SULFUR HEXAFLUORIDE;

ADOLESCENT; ARTICLE; BREATH ANALYSIS; BREATHING; CHILD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYSTIC FIBROSIS; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DOPPLER FLOWMETER; DOUBLE TRACER GAS SINGLE BREATH WASHOUT; FEASIBILITY STUDY; FEMALE; HUMAN; INTERMETHOD COMPARISON; LUNG CLEARANCE; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MULTIPLE BREATH NITROGEN WASHOUT; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; BREATH TESTS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CYSTIC FIBROSIS; FEASIBILITY STUDIES; FEMALE; FLOWMETERS; FORCED EXPIRATORY VOLUME; GASES; HUMANS; MALE; NITROGEN; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; PULMONARY VENTILATION; REPRODUCIBILITY OF RESULTS; SPIROMETRY; SULFUR HEXAFLUORIDE; TIDAL VOLUME;

EID: 84873393070     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00044312     Document Type: Article

References (41)

1. Gustafsson PM, De Jong PA, Tiddens HA, et al. Multiple-breath inert gas washout and spirometry versus structural lung disease in cystic fibrosis. Thorax 2008; 63: 129-134.
2. Owens CM, Aurora P, Stanojevic S, et al. Lung clearance index and HRCT are complementary markers of lung abnormalities in young children with CF. Thorax 2011; 66: 481-488.
3. Ellemunter H, Fuchs SI, Unsinn KM, et al. Sensitivity of lung clearance index and chest computed tomography in early CF lung disease. Respir Med 2010; 104: 1834-1842.
4. Hall GL, Logie KM, Parsons F, et al. Air trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening. PLoS One 2011; 6: e23932.
5. Hall GL, Stocks J. Intervention trials and ventilation distribution in mild cystic fibrosis lung disease: will it all come out in the washEur Respir J 2011; 37: 757-759.
6. Amin R, Subbarao P, Jabar A, et al. Hypertonic saline improves the LCI in paediatric patients with CF with normal lung function. Thorax 2010; 65: 379-383.
7. Amin R, Subbarao P, Lou W, et al. The effect of dornase alfa on ventilation inhomogeneity in patients with cystic fibrosis. Eur Respir J 2011; 37: 806-812.
8. Belessis Y, Dixon B, Hawkins G, et al. Early cystic fibrosis lung disease detected by bronchoalveolar lavage and lung clearance index. Am J Respir Crit Care Med 2012; 185: 862-873.
9. Horsley A. Lung clearance index in the assessment of airways disease. Respir Med 2009; 103: 793-799.
10. Crawford AB, Makowska M, Paiva M, et al. Convection-and diffusion-dependent ventilation maldistribution in normal subjects. J Appl Physiol 1985; 59: 838-846.
11. Estenne M, Van Muylem A, Knoop C, et al. Detection of obliterative bronchiolitis after lung transplantation by indexes of ventilation distribution. Am J Respir Crit Care Med 2000; 162: 1047-1051.
12. Van Muylem A, Baran D. Overall and peripheral inhomogeneity of ventilation in patients with stable cystic fibrosis. Pediatr Pulmonol 2000; 30: 3-9.
13. in 't Veen JC, Beekman AJ, Bel EH, et al. Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am J Respir Crit Care Med 2000; 161: 1902-1906.
14. Paiva M. Gas transport in the human lung. J Appl Physiol 1973; 35: 401-410.
15. Coates AL. Classical respiratory physiology-gone the way of the dinosaursDo we need a jurassic parkPediatr Pulmonol 2000; 30: 1-2.
16. Singer F, Stern G, Thamrin C, et al. Tidal volume single breath washout of two tracer gases-a practical and promising lung function test. PLoS One 2011; 6: e17588.
17. Beydon N, Davis SD, Lombardi E, et al. An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children. Am J Respir Crit Care Med 2007; 175: 1304-1345.
18. Singer F, Houltz B, Robinson PD, et al. A realistic validation study of a new nitrogen multiple-breath washout system. PLoS One 2012; 7: e36083.
19. Aurora P, Gustafsson P, Bush A, et al. Multiple breath inert gas washout as a measure of ventilation distribution in children with cystic fibrosis. Thorax 2004; 59: 1068-1073.
20. Gustafsson PM, Aurora P, Lindblad A. Evaluation of ventilation maldistribution as an early indicator of lung disease in children with cystic fibrosis. Eur Respir J 2003; 22: 972-979.
21. Verbanck S, Schuermans D, Vincken W. Inflammation and airway function in the lung periphery of patients with stable asthma. J Allergy Clin Immunol 2010; 125: 611-616.
22. Stanojevic S, Wade A, Cole TJ, et al. Spirometry centile charts for young Caucasian children: the Asthma UK Collaborative Initiative. Am J Respir Crit Care Med 2009; 180: 547-552.
23. Teculescu DB, Pham QT, Hannhart B, et al. Computerized singlebreath nitrogen washout in children: variability and reproducibility. Clin Physiol 1987; 7: 247-259.
24. Teculescu DB, Rebstock E, Caillier I, et al. Variability of the computerized single-breath nitrogen washout test in healthy adults. Results from a field survey in a French rural area. Clin Physiol 1993; 13: 35-50.
25. Aurora P, Bush A, Gustafsson P, et al. Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis. Am J Respir Crit Care Med 2005; 171: 249-256.
26. Fuchs SI, Ellemunter H, Eder J, et al. Feasibility and variability of measuring the lung clearance index in a multi-center setting. Pediatr Pulmonol 2012; 47: 649-657.
27. Gustafsson PM. Peripheral airway involvement in CF and asthma compared by inert gas washout. Pediatr Pulmonol 2007; 42: 168-176.
28. Gustafsson PM, Ljungberg HK, Kjellman B. Peripheral airway involvement in asthma assessed by single-breath SF6 and He washout. Eur Respir J 2003; 21: 1033-1039.
29. Van Muylem A, De Vuyst P, Yernault JC, et al. Inert gas singlebreath washout and structural alteration of respiratory bronchioles. Am Rev Respir Dis 1992; 146: 1167-1172.
30. Lacquet LM, Van Muylem A. He and SF6 single-breath expiration curves. Comparison with the paiva-engel model. Bull Eur Physiopathol Respir 1982; 18: 239-246.
31. McMahon CJ, Dodd JD, Hill C, et al. Hyperpolarized 3helium magnetic resonance ventilation imaging of the lung in cystic fibrosis: comparison with high resolution CT and spirometry. Eur Radiol 2006; 16: 2483-2490.
32. Crawford AB, Cotton DJ, Paiva M, et al. Effect of lung volume on ventilation distribution. J Appl Physiol 1989; 66: 2502-2510.
33. Crawford AB, Makowska M, Engel LA. Effect of tidal volume on ventilation maldistribution. Respir Physiol 1986; 66: 11-25.
34. Robinson PD, Goldman MD, Gustafsson PM. Inert gas washout: theoretical background and clinical utility in respiratory disease. Respiration 2009; 78: 339-355.
35. Van Muylem A, Antoine M, Yernault JC, et al. Inert gas singlebreath washout after heart-lung transplantation. Am J Respir Crit Care Med 1995; 152: 947-952.
36. von Nieding G, Lollgen H, Smidt U, et al. Simultaneous washout of helium and sulfur hexafluoride in healthy subjects and patients with chronic bronchitis, bronchial asthma, and emphysema. Am Rev Respir Dis 1977; 116: 649-660.
37. Green K, Buchvald FF, Marthin JK, et al. Ventilation inhomogeneity in children with primary ciliary dyskinesia. Thorax 2012; 67: 49-53.
38. Farah CS, King GG, Brown NJ, et al. The role of the small airways in the clinical expression of asthma in adults. J Allergy Clin Immunol 2012; 129: 381-387.
39. Verbanck S, Schuermans D, PaivaM, et al. Nonreversible conductive airway ventilation heterogeneity in mild asthma. J Appl Physiol 2003; 94: 1380-1386.
40. Verbanck S, Schuermans D, Paiva M, et al. Small airway function improvement after smoking cessation in smokers without airway obstruction. Am J Respir Crit Care Med 2006; 174: 853-857.
41. Verbanck S, Schuermans D, Meysman M, et al. Noninvasive assessment of airway alterations in smokers: the small airways revisited. Am J Respir Crit Care Med 2004; 170: 414-419.