Oral bacterial community dynamics in paediatric patients with malignancies in relation to chemotherapy-related oral mucositis: A prospective study

Clinical Microbiology and Infection

Volumn 19, Issue 12, 2013, Pages

  Ye, Y ^a,b   Carlsson, G ^c   Agholme, M Barr ^a   Wilson, J A L ^a   Roos, A ^a   Henriques Normark, B ^a,c   Engstrand, L ^a   Modeer T ^a   Putsep K ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b PEKING UNIVERSITY SCHOOL AND HOSPITAL OF STOMATOLOGY   (China)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

16S rRNA gene; 454 pyrosequencing; Cancer; Oral microflora; Stomatitis

Indexed keywords

AMINOGLYCOSIDE; BENZYDAMINE; CEPHALOSPORIN; CYTOSTATIC AGENT; MOUTHWASH; PENICILLIN DERIVATIVE; RNA 16S; THIENAMYCIN;

ARTICLE; CHEMOTHERAPY; CHILD; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROBIAL COMMUNITY; MICROBIAL DIVERSITY; MOUTH FLORA; ORAL DRUG ADMINISTRATION; ORAL MUCOSITIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PYROSEQUENCING; SCHOOL CHILD; SYSTEMIC DISEASE;

BACTERIA (MICROORGANISMS);

16S RRNA GENE; 454 PYROSEQUENCING; CANCER; ORAL MICROFLORA; STOMATITIS;

ADOLESCENT; ANTINEOPLASTIC AGENTS; BACTERIAL PHYSIOLOGICAL PHENOMENA; CHILD; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MICROBIOTA; MOUTH MUCOSA; NEOPLASMS; PROSPECTIVE STUDIES; RNA, RIBOSOMAL, 16S; SEQUENCE ANALYSIS, RNA; STOMATITIS;

EID: 84888045490     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/1469-0691.12287     Document Type: Article

References (40)

1. Sonis ST. Oral mucositis in cancer therapy. J Support Oncol 2004; 2: 3-8.
2. Scully C, Sonis S, Diz PD. Oral mucositis. Oral Dis 2006; 12: 229-241.
3. Sonis ST. The pathobiology of mucositis. Nat Rev Cancer 2004; 4: 277-284.
4. Napenas JJ, Brennan MT, Bahrani-Mougeot FK, Fox PC, Lockhart PB. Relationship between mucositis and changes in oral microflora during cancer chemotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 103: 48-59.
5. Van Vliet MJ, Harmsen HJ, De Bont ES, Tissing WJ. The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis. PLoS Pathog 2010; 6: e1000879.
6. Keijser BJ, Zaura E, Huse SM et al. Pyrosequencing analysis of the oral microflora of healthy adults. J Dent Res 2008; 87: 1016-1020.
7. Laheij AM, De Soet JJ, Von dem Borne PA et al. Oral bacteria and yeasts in relationship to oral ulcerations in hematopoietic stem cell transplant recipients. Support Care Cancer 2012; 20: 3231-3240.
8. Olczak-Kowalczyk D, Daszkiewicz M, Krasuska S et al. Bacteria and candida yeasts in inflammations of the oral mucosa in children with secondary immunodeficiency. J Oral Pathol Med 2012; 41: 568-576.
9. Amann RI, Ludwig W, Schleifer KH. Phylogenetic identification and in situ detection of individual microbial cells without cultivation. Microbiol Rev 1995; 59: 143-169.
10. Rothberg JM, Leamon JH. The development and impact of 454 sequencing. Nat Biotechnol 2008; 26: 1117-1124.
11. Hollister EB, Engledow AS, Hammett AJ, Provin TL, Wilkinson HH, Gentry TJ. Shifts in microbial community structure along an ecological gradient of hypersaline soils and sediments. ISME J 2010; 4: 829-838.
12. WHO. Handbook for reporting results of cancer treatment. Geneva, Switzerland: World Health Organization, 1979.
13. Andersson AF, Lindberg M, Jakobsson H, Backhed F, Nyren P, Engstrand L. Comparative analysis of human gut microbiota by barcoded pyrosequencing. PLoS ONE 2008; 3: e2836.
14. Ye Y, Carlsson G, Wondimu B et al. Mutations in the ELANE gene are associated with development of periodontitis in patients with severe congenital neutropenia. J Clin Immunol 2011; 31: 936-945.
15. Margulies M, Egholm M, Altman WE et al. Genome sequencing in microfabricated high-density picolitre reactors. Nature 2005; 437: 376-380.
16. Quince C, Lanzen A, Davenport RJ, Turnbaugh PJ. Removing noise from pyrosequenced amplicons. BMC Bioinformatics 2011; 12: 38.
17. Cole JR, Wang Q, Cardenas E et al. The ribosomal database project: improved alignments and new tools for rrna analysis. Nucleic Acids Res 2009; 37: D141-D145.
18. Quast C, Pruesse E, Yilmaz P et al. The silva ribosomal rna gene database project: improved data processing and web-based tools. Nucleic Acids Res 2013; 41: D590-D596.
19. Saeed AI, Sharov V, White J et al. Tm4: a free, open-source system for microarray data management and analysis. Biotechniques 2003; 34: 374-378.
20. Hamady M, Lozupone C, Knight R. Fast unifrac: facilitating high-throughput phylogenetic analyses of microbial communities including analysis of pyrosequencing and phylochip data. ISME J 2010; 4: 17-27.
21. Robinson MD, McCarthy DJ, Smyth GK. Edger: a bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 2010; 26: 139-140.
22. Abrahamsson TR, Jakobsson HE, Andersson AF, Bjorksten B, Engstrand L, Jenmalm MC. Low diversity of the gut microbiota in infants with atopic eczema. J Allergy Clin Immunol 2012; 129: 434-440.
23. Renard KW, Marling-Cason M, Sheehan RG, Mackowiak PA. Effects of cancer chemotherapy on the human aerobic oropharyngeal flora. Infection 1986; 14: 237-242.
24. Peiris V, Oppenheim BA. Antimicrobial activity of cytotoxic drugs may influence isolation of bacteria and fungi from blood cultures. J Clin Pathol 1993; 46: 1124-1125.
25. Fanaki NH, el-Nakeeb MA. Antimicrobial activity of benzydamine, a non-steroid anti-inflammatory agent. J Chemother 1992; 4: 347-352.
26. Ascierto ML, De Giorgi V, Liu Q et al. An immunologic portrait of cancer. J Transl Med 2011; 9: 146.
27. Ye Y, Carlsson G, Barr Agholme M et al. Pretherapeutic plasma pro- and anti- inflammatory mediators are related to high risk of oral mucositis in pediatric patients with acute leukemia: a prospective cohort study. PLoS ONE 2013; 8: e64918.
28. Griffen AL, Beall CJ, Campbell JH et al. Distinct and complex bacterial profiles in human periodontitis and health revealed by 16s pyrosequencing. ISME J 2012; 6: 1176-1185.
29. Li Y, Ge Y, Saxena D, Caufield PW. Genetic profiling of the oral microbiota associated with severe early-childhood caries. J Clin Microbiol 2007; 45: 81-87.
30. Parenti DM, Snydman DR. Capnocytophaga species: infections in nonimmunocompromised and immunocompromised hosts. J Infect Dis 1985; 151: 140-147.
31. Baquero F, Fernandez J, Dronda F et al. Capnophilic and anaerobic bacteremia in neutropenic patients: an oral source. Rev Infect Dis 1990; 12 (suppl 2): S157-S160.
32. Van Vliet MJ, Tissing WJ, Dun CA et al. Chemotherapy treatment in pediatric patients with acute myeloid leukemia receiving antimicrobial prophylaxis leads to a relative increase of colonization with potentially pathogenic bacteria in the gut. Clin Infect Dis 2009; 49: 262-270.
33. Stringer AM, Gibson RJ, Logan RM et al. Gastrointestinal microflora and mucins may play a critical role in the development of 5-fluorouracil-induced gastrointestinal mucositis. Exp Biol Med 2009; 234: 430-441.
34. Napenas JJ, Brennan MT, Coleman S et al. Molecular methodology to assess the impact of cancer chemotherapy on the oral bacterial flora: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: 554-560.
35. Lucas VS, Beighton D, Roberts GJ, Challacombe SJ. Changes in the oral streptococcal flora of children undergoing allogeneic bone marrow transplantation. J Infect 1997; 35: 135-141.
36. Bochud PY, Calandra T, Francioli P. Bacteremia due to viridans streptococci in neutropenic patients - a review. Am J Med 1994; 97: 256-264.
37. Rossetti F, Cesaro S, Putti MC, Zanesco L. High-dose cytosine arabinoside and viridans streptococcus sepsis in children with leukemia. Pediatr Hematol Oncol 1995; 12: 387-392.
38. Landsaat PM, Van der Lelie H, Bongaerts G, Kuijper EJ. Fusobacterium nucleatum, a new invasive pathogen in neutropenic patients? Scand J Infect Dis 1995; 27: 83-84.
39. Schwartz DN, Schable B, Tenover FC, Miller RA. Leptotrichia buccalis bacteremia in patients treated in a single bone marrow transplant unit. Clin Infect Dis 1995; 20: 762-767.
40. Sonalika WG, Amsavardani Tayaar S, Bhat KG, Patil BR, Muddapur MV. Oral microbial carriage in oral squamous cell carcinoma patients at the time of diagnosis and during radiotherapy - a comparative study. Oral Oncol 2012; 48: 881-886.