Effects of Nigella sativa L. seed oil in type II diabetic patients: A randomized, double-blind, placebo - Controlled clinical trial

Journal of Medicinal Plants

Volumn 12, Issue 47, 2013, Pages 93-99

  Hosseini, M S ^a   Mirkarimi, S A ^a   Amini, M ^a   Mohtashami, R ^a   Kianbakht, S ^b   Fallah Huseini, H ^b  

^a BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b AVICENNA RESEARCH INSTITUTE   (Iran)

Author keywords

Blood glucose; Diabetes; Nigella sativa; Traditional medicine

Indexed keywords

GLIBENCLAMIDE; GLUCOSE; HEMOGLOBIN A1C; METFORMIN; MINERAL OIL; NIGELLA SATIVA SEED OIL; PLACEBO; UNCLASSIFIED DRUG; VEGETABLE OIL;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; ANTIDIABETIC ACTIVITY; ARTICLE; BLACK CUMIN; BODY MASS; CONTROLLED STUDY; DIABETIC PATIENT; DOUBLE BLIND PROCEDURE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; KIDNEY FUNCTION TEST; LIPID ANALYSIS; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POSTPRANDIAL STATE; RANDOMIZED CONTROLLED TRIAL;

NIGELLA SATIVA;

EID: 84888042556     PISSN: 2717204X     EISSN: 27172058     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Shaw JE, Sicree RA and Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res. Clin. Pract. 2010; 87: 4-14.
2. Arulselvan P, Senthilkumar GP, Kumar SD and Subramanian S. Anti-diabetic effect of Murraya koenigii leaves on streptozotocin induced diabetic rats. Pharmazie 2006; 61: 874-7.
3. Huseini HF, Larijani B, Fakhrzadeh H, Radjabipour B, Toliat T and Reza M. The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Phototherapy Res. 2006; 20: 1036-9.
4. Salehi Surmaghi MH. Nigella sativa. In Herbal Medicine and Herbal Therapy, volum 2, Donyay Taghziah press. Tehran Iran. 2008, pp: 216-9.
5. Malhotra SK. Nigella In Handbook of herbs and spices vol.2, K. V. Peter (ed), CRC Press, Woodhead Publishing Limited, Abington Hall, Abington. Cambridge CB1 6AH, England. 2004, pp: 218-26.
6. Jazayeri GhA. Black Cumin. In Zaban-e-khorakiha, volum 3, Amir kabir press: Tehran Iran 2004, 53-4.
7. Haji Sharifi A. Black Cumin. In Secretes in Medicinal Plants (3rd ed) Hafez-e-Novin press: Tehran Iran. 2003, pp: 658-61.
8. Anwar Briro M and Tayyab M. Effect of Nigella sativa on lipid profile in albino rats. Gomal Journal of Medical Sciences 2007; 5: 28-31.
9. El-Dakhakhny M, Mady N, Lembert N and Ammon HP. The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions. Planta Med. 2002; 68: 465-6.
10. Bamosa AO, Kaatabi H, Lebda FM, Al Elq AM and Al sultan A. Effects of Nigella sativa seeds on the glycemic control on patients with diabetes milltus. Indian J. Physiol. Pharmacol. 2010; 54: 344-54.
11. Sabzghabaee AM, Dianatkhah M, Sarrafzadegan N, Asgary S and Ghannadi AR. Clinical evaluation of nigella sativa seeds for the treatment of hyperlipidemia. Med. Arh. 2012; 66: 198-200.
12. Shahzad FH, Nasiruddin M and Najmi A. Indigenous herbal product Nigella sativa proved effective as an anti-obesity therapy in metabolic syndrome. International Journal of Medicobiological Res. 2011; 1: 133-76.
13. Najmi A, Nasiruddin M, Ali Khan R and Haque SF. Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome. Int. J. Diabetes Dev. Ctries 2008; 28: 11-4.
14. Mohtashami R, Amini M, Fallah Huseini H, Ghamarchehre M, Sadeqhi Z, Hajiagaee R and Fallah Huseini A. Blood glucose lowering effects of Nigella Sativa L. seeds oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial. Journal of Medicinal Plants 2011; 10: 90-4.
15. Alsaif MA. Effect of N. sativa Oil on Impaired Glucose Tolerance and Insulin Insensitivity Induced by High-Fat-Diet and Turpentine-Induced Trauma. Pakistan Journal of Biological Sciences 2008; 11: 1093-9.
16. Kanter M, Meral I, Yener Z, Ozbek H and Demir H. Partial Regeneration / Proliferation of the β-cells in the islets of Langerhans by N. sativa L in Streptozotocin-induced diabetic rats. Tohoku J. Ex.p Med. 2003; 201: 213-9.
17. Amin S, Mir SR, Kohli K, Ali B and Ali M. A study of the chemical composition of black cumin oil and its effect on penetration enhancement from transdermal formulations. Nat. Prod. Res. 2010; 24: 1151-7.
18. Houseknecht KL, Vanden Heuvel JP, Moya-Camarena SY, Portocarrero CP, Peck LW, Nickel KP and Belury MA. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys. Res. Commun. 1998; 244: 678-82.
19. Ryan M, McInerney D, Owens D, Collins P, Johnson A and Tomkin GH. Diabetes and the Mediterranean diet: a beneficial effect of oleic acid on insulin sensitivity, adipocyte glucose transport and endothelium-dependent vasoreactivity. QJM. 2000; 93: 85-91.
20. Pourghassem-Gargari B, Ebrahimzadeh-Attary V, Rafraf M and Gorbani A. Effect of dietary supplementation with Nigella sativa L. on serum lipid profile, lipid peroxidation and antioxidant defense system in hyperlipidemic rabbits. Journal of Medicinal Plants Research 2009; 3: 815-21.
21. Tuter M, Secundo F, Riva S, H. Ayşe Aksoy and Ustun G. Partial purification of Nigella sativa L. Seed lipase and its application in transesterification reactions. Journal of Oil & Fat Industries 2002; 80: 43-8.