TRAF6-mediated ubiquitination of NEMO requires p62/sequestosome-1

Molecular Immunology

Volumn 58, Issue 1, 2014, Pages 27-31

  Zotti, Tiziana ^a   Scudiero, Ivan ^a   Settembre, Pio ^a,b   Ferravante, Angela ^a   Mazzone, Pellegrino ^a,b   D'Andrea, Luca ^a,b   Reale, Carla ^a   Vito, Pasquale ^b,c   Stilo, Romania ^a,b  

^a Grande Ospedale Metropolitano   (Italy)

^b UNIVERSITY OF SANNIO   (Italy)

^c Qatar University   (Qatar)

Author keywords

IL 1 ; NF B; P62 sequestosome; TNF ; TRAF6; Ubiquitin

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN ESSENTIAL MODULATOR; INTERLEUKIN 1BETA; MESSENGER RNA; PROTEIN P62; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN INTERACTION; UBIQUITINATION;

IL-1Β; NF-ΚB; P62/SEQUESTOSOME; TNFΑ; TRAF6; UBIQUITIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL LINE; HEK293 CELLS; HUMANS; I-KAPPA B KINASE; INTERLEUKIN-1BETA; NF-KAPPA B; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; UBIQUITINATION;

EID: 84888039740     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2013.10.015     Document Type: Article

References (29)

1. Abbott D.W., Yang Y., Hutti J.E., Madhavarapu S., Kelliher M.A., et al. Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains. Mol. Cell. Biol. 2007, 27:6012-6025.
2. Baltimore D. Discovering NF-κB. Cold Spring Harb. Perspect. Biol. 2009, 1:a000026.
3. Bonizzi G., Karin M. The two NF-κB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 2004, 25:280-288.
4. Chen J., Chen Z.J. Regulation of NF-κB by ubiquitination. Curr. Opin. Immunol. 2013, 25(1):4-12.
5. Chiu Y.H., et al. Ubiquitin in NF-κB signaling. Chem. Rev. 2009, 109:1549-1560.
6. Deng L., Wang C., Spencer E., Yang L., Braun A., et al. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 2000, 103:351-361.
7. Duran A., et al. The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev. Cell 2004, 6:303-309.
8. Duran A., et al. p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Mol. Cell 2011, 44:134-146.
9. Geetha T., Jiang J., Wooten M.W. Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling. Mol. Cell 2005, 20:301-312.
10. Ha H., Han D., Choi Y. TRAF-mediated TNFR-family signaling. Curr. Protoc. Immunol. 2009, 11. (Charter 11: Unit 11.9D).
11. Harhaj E.W., Dixit V.M. Deubiquitinases in the regulation of NF-κB signaling. Cell Res. 2011, 21:22-39.
12. Hayden M.S., Ghosh S. Shared principles in NF-κB signaling. Cell 2008, 132:344-362.
13. Hymowitz S.G., Wertz I.E. A20: from ubiquitin editing to tumour suppression. Nat. Rev. Cancer 2010, 10:332-341.
14. Kanayama A., Seth R.B., Sun L., Ea C.K., Hong M., et al. TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol. Cell 2004, 15:535-548.
15. Moscat J. Diaz-Meco MT. p62: a versatile multitasker takes on cancer. Trends Biochem. Sci. 2012, 37(June (6)):230-236.
16. Sanz L., et al. The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J. 2000, 19:1576-1586.
17. Seibenhener M.L., Babu J.R., Geetha T., Wong H.C., Krishna N.R., Wooten M.W. Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol. Cell. Biol. 2004, 24(18):8055-8068.
18. Skaug B., et al. The role of ubiquitin in NF-κB regulatory pathways. Annu. Rev. Biochem. 2009, 78:769-796.
19. Stilo R., Varricchio E., Liguoro D., Leonardi A., Vito P. A20 is a negative regulator of BCL10- and CARMA3-mediated activation of NF-kappaB. J. Cell Sci. 2008, 121(Pt 8):1165-1171.
20. Sun S.C. CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes. Cell Death Differ. 2010, 17:25-34.
21. Sun S.C. Non-canonical NF-κB signaling pathway. Cell Res. 2011, 21:71-85.
22. Tokunaga F., et al. Involvement of linear polyubiquitylation of NEMO in NF-κB activation. Nat. Cell Biol. 2009, 11:123-132.
23. Vessichelli M., et al. Neuroepithelial transforming gene 1 (Net1) binds to caspase activation and recruitment domain (CARD)- and membrane-associated guanylate kinase-like domain-containing (CARMA) proteins and regulates nuclear factor κB activation. J. Biol. Chem. 2012, 287(17):13722-13730.
24. Walsh M.C., Kim G.K., Maurizio P.L., Molnar E.E., Choi Y. TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL. PLoS ONE 2008, 3(12):e4064.
25. Wooten M.W., et al. The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. J. Biol. Chem. 2005, 280:35625-35629.
26. Wooten M.W., Geetha T., Seibenhener M.L., Babu J.R., Diaz-Meco M.T., Moscat J. The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. J. Biol. Chem. 2005, 280(42):35625-35629.
27. Xu M., et al. A Ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFa and IL-1b. Mol. Cell 2009, 36:302-314.
28. Zotti T., et al. TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation. J. Biol. Chem. 2011, 286(26):22924-22933.
29. Zotti T., Vito P., Stilo R. The seventh ring: exploring TRAF7 functions. J. Cell. Physiol. 2012, 227(3):1280-1284.