An in vivo study examining the antiinflammatory effects of chamomile, meadowsweet, and willow bark in a novel functional beverage

Journal of Dietary Supplements

Volumn 10, Issue 4, 2013, Pages 370-380

  Drummond, Elaine M ^a   Harbourne, Niamh ^a   Marete, Eunice ^a   Jacquier, J C ^a   O'Riordan, Dolores ^a   Gibney, Eileen R ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Chamomile; Inflammation; Meadowsweet; Willow bark

Indexed keywords

ANTIINFLAMMATORY AGENT; CHAMOMILE; CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; PHENOL DERIVATIVE; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BACK; BEVERAGE; BLOOD; BLUEBERRY; CHEMISTRY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FILIPENDULA; FRUIT; HUMAN; JOINT; JOINT CHARACTERISTICS AND FUNCTIONS; KNEE; PHYTOTHERAPY; RANDOMIZED CONTROLLED TRIAL; WILLOW;

ADULT; ANTI-INFLAMMATORY AGENTS; BACK; BEVERAGES; BLUEBERRY PLANT; CHAMOMILE; CYTOKINES; FILIPENDULA; FRUIT; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; JOINTS; KNEE; KNEE JOINT; PHENOLS; PHYTOTHERAPY; PLANT EXTRACTS; RANGE OF MOTION, ARTICULAR; SALIX; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84888023348     PISSN: 19390211     EISSN: 1939022X     Source Type: Journal    
DOI: 10.3109/19390211.2013.830680     Document Type: Article

References (31)

1. Agnolet S, Wiese S, Verpoorte R, Staerk D. Comprehensive analysis of commercial willow bark extracts by new technology platform: combined use of metabolomics, high-performance liquid chromatography-solid-phase extraction-nuclear magnetic resonance spectroscopy and highresolution radical scavenging assay. J Chromatogr A. 2012;1262:130-137.
2. Barkin RL, Buvanendran A. Focus on the COX-1 and COX-2 agents: renal events of nonsteroidal and anti-inflammatory drugs-NSAIDs. Am J Ther. 2004;11(2):124-129.
3. Bhaskaran N, Shukla S, Srivastava JK, Gupta SG. Chamomile, an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity. Int JMol Med. 2010;26(6):935-940.
4. Boehm J, Fischer K, Bohnert M. Putative role of TNF-alpha, interleukin-8 and ICAM-1 as indicators of an early inflammatory reaction after burn: a morphological and immunohistochemical study of lung tissue of fire victims. J Clin Pathol. 2010;63(11):967-971.
5. Butler DM, Maini RN, Feldmann M, Brennan FM. Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist. Eur Cytokine Netw. 1995;6(4):225-230.
6. Chikanza IC, Kingsley G, et al. Peripheral-Blood and Synovial-Fluid Monocyte Expression of Interleukin-1-Alpha and 1-Beta during Active Rheumatoid-Arthritis. Journal of Rheumatology. 1995;22(4):600-606.
7. Choy EHS, Panayi GS. Mechanisms of disease: cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med. 2001;344(12):907-916.
8. Chrubasik S, Eisenberg E, Balan E, et al. Treatment of low back pain exacerbations with willow bark extract: a randmized double-blind study. Am J Med. 2000;109:9-14.
9. Comalada M, Ballester I, et al. Inhibition of pro-inflammatory markers in primary bone marrowderived mouse macrophages by naturally occurring flavonoids: Analysis of the structureactivity relationship. Biochem Pharmacol. 2006;72(8):1010-1021.
10. Drummond EM, Harbourne N, et al. Inhibition of Proinflammatory Biomarkers in THP1 Macrophages by Polyphenols Derived From Chamomile, Meadowsweet and Willow bark. Phytotherapy Research. 2013;27(4):588-594.
11. Fairbank JCT, Pynsent PB, et al. Quantitative Measurements of Joint Mobility in Adolescents. Annals of the Rheumatic Diseases. 1984;43(2):288-294.
12. Freischmidt A, Jurgenliemk G, et al. Contribution of flavonoids and catechol to the reduction of ICAM-1 expression in endothelial cells by a standardised Willow bark extract. Phytomedicine. 2011;19(3-4):245-252.
13. Garcia-Mediavilla V, Crespo I, et al. The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol. 2007;557(2-3):221-229.
14. Harbourne N, Jacquier JC, et al. Optimisation of the aqueous extraction conditions of phenols from meadowsweet (Filipendula ulmaria L.) for incorporation into beverages. Food Chemistry. 2009a;116(3):722-727.
15. Harbourne N, Jacquier JC, et al. Optimisation of the extraction and processing conditions of chamomile (Matricaria chamomilla L.) for incorporation into a beverage. Food Chemistry. 2009b;115(1):15-19.
16. Harbourne N, Marete E, et al. Effect of drying methods on the phenolic constituents of meadowsweet (Filipendula ulmaria) and willow (Salix alba). Lwt-Food Science and Technology. 2009c;42(9): 1468-1473.
17. Hedner T, Everts B. The early clinical history of salicylates in rheumatology and pain. Clin Rheumatol. 1998;17(1): 17-25.
18. Kelly JP, Kaufman DW, et al. Recent trends in use of herbal and other natural products. Arch Intern Med. 2005;165(3):281-286.
19. Liang YC, Huang YT, et al. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis. 1999;20(10):1945-1952.
20. Lopez-Varela S, Gonzalez-Gross M, et al. Functional foods and the immune system: a review. Eur J Clin Nutr. 2002;56:S29-S33.
21. Mamani-Matsuda M, Kauss T, et al. Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators. Biochem Pharmacol. 2006;72(10):1304-1310.
22. Martel F, Monteiro R, et al. Effect of polyphenols on the intestinal and placental transport of some bioactive compounds. Nutr Res Rev. 2010;23(1):47-64.
23. Nawroth PP, Bank I, et al. Tumor necrosis factor/cachectin interacts with endothelial-cell receptors to induce release of interleukin-1. J Exp Med. 1986;163(6):1363-1375.
24. Peterson J, Dwyer J. Flavonoids: dietary occurrence and biochemical activity. Nutr Res. 1988;18(12):1995-2018.
25. Saxne T, Palladino MA, et al. Detection of tumor necrosis factor-alpha but not tumor necrosis factor-beta in rheumatoid-arthritis synovial-fluid and serum. Arthritis Rheum. 1988;31(8):1041-1045.
26. Setty AR, Sigal LH. Herbal medications commonly used in the practice of rheumatology: Mechanisms of action, efficacy, and side effects. Semin Arthritis Rheum. 2005;34(6):773-784.
27. Shingu M, Nagai Y, et al. The effects of cytokines on metalloproteinase inhibitors (Timp) and collagenase production by human chondrocytes and timp production by synovial-cells and endothelial-cells. Clin Exp Immunol. 1993;94(1):145-149.
28. Singleton VL, Rossi JA. Colorimtery of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents. American Journal of Enology and Viticulture. 1965;16(3):144-158.
29. Smolinski AT, Pestka JJ. Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb-1 (ginseng) and parthenolide (feverfew). Food Chem Toxicol. 2003;41(10):1381-1390.
30. Tordjman FC, Andre N, Rique H, Spedding M, Bonnet J. Characterisation of cyclooxygenase 1 and 2 expression in mouse peritoneal macrophages in vitro; interaction of non-steroidal antiinflammatory drugs with COX-2. Biochim Biophys Acta. 1995;1256:249-256.
31. Zern TL, Wood RJ, Greene CG, West KL, Liu Y, Aggarwal D, Shachter NS, Fernandez ML. Grape polyphenols exert a cardioprotective effect in pre- and postmenapausal women by lowering plasma lipids and reducing oxidative stress. J Nutr. 2005;135:1911-1917.