Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment

Diabetologia

Volumn 56, Issue 12, 2013, Pages 2697-2701

  Frangioudakis, Georgia ^a,b   Diakanastasis, Barbara ^a   Liao, Bing Qing M ^a   Saville, Jennifer T ^c   Hoffman, Nolan J ^a   Mitchell, Todd W ^c   Schmitz Peiffer, Carsten ^a,b  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

Akt; Ceramide; Fatty acid; Glycogen synthesis; Insulin resistance; IRS1; L6 muscle cell; Palmitate; Sphingomyelin

Indexed keywords

CERAMIDE; CERAMIDE SYNTHASE; CERAMIDE SYNTHASE 1; CERAMIDE SYNTHASE 2; CERAMIDE SYNTHASE 4; CERAMIDE SYNTHASE 5; CERAMIDE SYNTHASE 6; GLUCOSE TRANSPORTER 4; INSULIN; MESSENGER RNA; PALMITIC ACID; PROTEIN KINASE B; SMALL INTERFERING RNA; SPHINGOLIPID; SPHINGOMYELIN; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CERS1 GENE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; GENE OVEREXPRESSION; GLUCOSE METABOLISM; GLYCOGEN SYNTHESIS; HUMAN; INSULIN RESISTANCE; INSULIN RESPONSE; MUSCLE CELL; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE; UPREGULATION;

CERAMIDES; GLUCOSE; GLYCOGEN; HUMANS; INSULIN; INSULIN RESISTANCE; MASS SPECTROMETRY; MEMBRANE PROTEINS; MUSCLE FIBERS, SKELETAL; MUSCLE, SKELETAL; OXIDOREDUCTASES; PALMITATES; PHOSPHORYLATION; PROTEIN ISOFORMS; SPHINGOLIPIDS;

EID: 84888014316     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3035-5     Document Type: Article

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