A study of genomic instability in early preneoplastic colonic lesions

Oncogene

Volumn 32, Issue 46, 2013, Pages 5333-5337

  Beggs, A D ^a,b   Domingo, E ^a   Abulafi, M ^b   Hodgson, S V ^c   Tomlinson, I P M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b MAYDAY UNIVERSITY HOSPITAL   (United Kingdom)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

colorectal cancer; gland; heterogeneity; methylation; microsatellite instability

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MISMATCH REPAIR PROTEIN; MISMATCH REPAIR PROTEIN PMS2; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH3; PROTEIN MSH6;

ADENOMATOUS POLYP; ADULT; AGED; ARTICLE; COLON POLYP; COLORECTAL ADENOMA; COLORECTAL CANCER; COLORECTAL POLYP; CONTROLLED STUDY; DISEASE ASSOCIATION; DYSPLASIA; FEMALE; GENE LOSS; GENETIC HETEROGENEITY; GENOMIC INSTABILITY; HUMAN; HUMAN TISSUE; HYPERPLASIA; LASER CAPTURE MICRODISSECTION; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; PRECANCER; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION;

COLORECTAL NEOPLASMS; DNA METHYLATION; GENOMIC INSTABILITY; HUMANS; LIGANDS; PRECANCEROUS CONDITIONS; PROMOTER REGIONS, GENETIC;

EID: 84888012302     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.584     Document Type: Article

References (21)

1. Sieber OM, Heinimann K, Tomlinson IP. Genomic instability-the engine of tumorigenesis? Nat Rev Cancer 2003; 3: 701-708.
2. Fearon ER, Hamilton SR, Vogelstein B. Clonal analysis of human colorectal tumors. Science 1987; 238: 193-197. (Pubitemid 17139720)
3. Kloor M, Huth C, Voigt AY, Benner A, Schirmacher P, von Knebel Doeberitz M et al. Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study. Lancet Oncol 2012; 13: 598-606.
4. Yurgelun MB, Goel A, Hornick JL, Sen A, Turgeon DK, MTt Ruffin et al. Microsatellite instability and DNA mismatch repair protein deficiency in Lynch syndrome colorectal polyps. Cancer prevention research 2012; 5: 574-582.
5. Brueckl WM, Jung A, Wein A, Brabletz T, Guenther K, Nusko G et al. Microsatellite instability in colorectal adenomas: relevance and clinical importance. Int J Colorectal Dis 2000; 15: 189-196.
6. Rashid A, Zahurak M, Goodman SN, Hamilton SR. Genetic epidemiology of mutated K-ras proto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomas. Gut 1999; 44: 826-833. (Pubitemid 29244219)
7. Samowitz WS, Slattery ML. Microsatellite instability in colorectal adenomas. Gastroenterology 1997; 112: 1515-1519. (Pubitemid 27181375)
8. Samowitz WS, Slattery ML. Transforming growth factor-beta receptor type 2 mutations and microsatellite instability in sporadic colorectal adenomas and carcinomas. Am J Pathol 1997; 151: 33-35. (Pubitemid 27283954)
9. Lothe RA, Andersen SN, Hofstad B, Meling GI, Peltomaki P, Heim S et al. Deletion of 1p loci and microsatellite instability in colorectal polyps. Genes Chromosomes Cancer 1995; 14: 182-188.
10. Lanza G, Gafa R, Maestri I, Santini A, Matteuzzi M, Cavazzini L. Immunohistochemical pattern of MLH1/MSH2 expression is related to clinical and pathological features in colorectal adenocarcinomas with microsatellite instability. Mod Pathol 2002; 15: 741-749. (Pubitemid 34787310)
11. Cunningham JM, Christensen ER, Tester DJ, Kim CY, Roche PC, Burgart LJ et al. Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability. Cancer Res 1998; 58: 3455-3460. (Pubitemid 28371090)
12. Umetani N, de Maat MF, Sunami E, Hiramatsu S, Martinez S, Hoon DS. Methylation of p16 and Ras association domain family protein 1a during colorectal malignant transformation. Mol Cancer Res 2006; 4: 303-309. (Pubitemid 43837331)
13. Belshaw NJ, Pal N, Tapp HS, Dainty JR, Lewis MP, Williams MR et al. Patterns of DNA methylation in individual colonic crypts reveal aging and cancer-related field defects in the morphologically normal mucosa. Carcinogenesis 2010; 31: 1158-1163.
14. Aaltonen LA, Peltomaki P, Leach FS, Sistonen P, Pylkkanen L, Mecklin JP et al. Clues to the pathogenesis of familial colorectal cancer. Science 1993; 260: 812-816. (Pubitemid 23167611)
15. Koh DC, Luchtefeld MA, Kim DG, Attal H, Monroe T, Ingersoll K. Microsatellite instability and MLH1 hypermethylation-incidence and significance in colorectal polyps in young patients. Colorectal Dis 2007; 9: 521-526. (Pubitemid 46958542)
16. Ahlquist T, Lind GE, Costa VL, Meling GI, Vatn M, Hoff GS et al. Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers. Mol Cancer 2008; 7: 94.
17. Lipkin SM, Wang V, Jacoby R, Banerjee-Basu S, Baxevanis AD, Lynch HT et al. MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability. Nat Genet 2000; 24: 27-35. (Pubitemid 30041416)
18. Guerrette S, Wilson T, Gradia S, Fishel R. Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer. Mol Cell Biol 1998; 18: 6616-6623. (Pubitemid 28500550)
19. Jeuken JW, Cornelissen SJ, Vriezen M, Dekkers MM, Errami A, Sijben A et al. MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas. Lab Invest 2007; 87: 1055-1065. (Pubitemid 47429190)
20. Park CK, Kim J, Yim SY, Lee AR, Han JH, Kim CY et al. Usefulness of MS-MLPA for detection of MGMT promoter methylation in the evaluation of pseudoprogression in glioblastoma patients. Neuro Oncol 2011; 13: 195-202.
21. Poynter JN, Siegmund KD, Weisenberger DJ, Long TI, Thibodeau SN, Lindor N et al. Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening. Cancer Epidemiol Biomarkers Prev 2008; 17: 3208-3215.