Methylation of p16 and Ras association domain family protein 1a during colorectal malignant transformation

Molecular Cancer Research

Volumn 4, Issue 5, 2006, Pages 303-309

  Umetani, Naoyuki ^a   De Maat, Michiel F G ^a   Sunami, Eiji ^a   Hiramatsu, Suzanne ^a   Martinez, Steve ^a   Hoon, Dave S B ^a  

^a JOHN WAYNE CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BISULFITE; FORMALDEHYDE; HEMATOXYLIN; PARAFFIN; PROTEIN P16; PROTEINASE K; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A;

ADENOMA; ARTICLE; CELL HETEROGENEITY; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; DNA MODIFICATION; HISTOLOGY; HUMAN; HUMAN TISSUE; MALIGNANT TRANSFORMATION; MICRODISSECTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

ALU ELEMENTS; BASE SEQUENCE; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; DNA METHYLATION; ESTROGEN RECEPTOR ALPHA; FEMALE; GENES, P16; HUMANS; MALE; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); SITE-SPECIFIC DNA METHYLTRANSFERASE (CYTOSINE-SPECIFIC); SULFITES; THYMINE DNA GLYCOSYLASE; TUMOR SUPPRESSOR PROTEINS;

EID: 33744822975     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-05-0199     Document Type: Article

References (26)

1. Ehrlich M, Gama-Sosa MA, Huang LH, et al. Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic Acids Res 1982;10:2709-21.
2. Bird AP. CpG-rich islands and the function of DNA methylation. Nature 1986; 321:209-13.
3. Bird A. The essentials of DNA methylation. Cell 1992;70:5-8.
4. Jones PA. DNA methylation errors and cancer. Cancer Res 1996;56:2463-7.
5. Esteller M, Herman JG. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J Pathol 2002;196:1-7.
6. Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003;349:2042-54.
7. Shen L, Kondo Y, Rosner GL, et al. MGMT promoter methylation and field defect in sporadic colorectal cancer. J Natl Cancer Inst 2005;97:1330-8.
8. Akino K, Toyota M, Suzuki H, et al. The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. Gastroenterology 2005;129: 156-69.
9. Wang RY, Gehrke CW, Ehrlich M. Comparison of bisulfite modification of 5-methyldeoxycytidine and deoxycytidine residues. Nucleic Acids Res 1980;8: 4777-90.
10. Frommer M, McDonald LE, Millar DS, et al. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci U S A 1992;89:1827-31.
11. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 1996;93:9821-6.
12. Xiong Z, Laird PW. COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res 1997;25:2532-4.
13. Eads CA, Danenberg KD, Kawakami K, et al. MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res 2000; 28:E32.
14. Zeschnigk M, Bohringer S, Price EA, Onadim Z, Masshofer L, Lohmann DR. A novel real-time PCR assay for quantitative analysis of methylated alleles (QAMA): analysis of the retinoblastoma locus. Nucleic Acids Res 2004;32:e125.
15. Millar DS, Warnecke PM, Melki JR, Clark SJ. Methylation sequencing from limiting DNA: embryonic, fixed, and microdissected cells. Methods 2002;27: 108-13.
16. Dubeau L, Chandler LA, Gralow JR, Nichols PW, Jones PA. Southern blot analysis of DNA extracted from formalin-fixed pathology specimens. Cancer Res 1986;46:2964-9.
17. Grunau C, Clark SJ, Rosenthal A. Bisulfite genomic sequencing: systematic investigation of critical experimental parameters. Nucleic Acids Res 2001;29: E65-5.
18. Nakayama M, Bennett CJ, Hicks JL, et al. Hypermethylation of the human glutathione S-transferase-π gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-capture microdissection. Am J Pathol 2003;163:923-33.
19. Nuovo GJ, Plaia TW, Belinsky SA, Baylin SB, Herman JG. In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis. Proc Natl Acad Sci U S A 1999;96:12754-9.
20. Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome. Nature 2001;409:860-921.
21. Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-32.
22. Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 1994;7:536-40,
23. Spugnardi M, Tommasi S, Dammann R, Pfeifer GP, Hoon DS. Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma. Cancer Res 2003;63:1639-43.
24. Olek A, Oswald J, Walter J. A modified and improved method for bisulphite based cytosine methylation analysis. Nucleic Acids Res 1996;24:5064-6.
25. Umetani N, de Maat MF, Mori T, Takeuchi H, Hoon DS. Synthesis of universal unmethylated control DNA by nested whole genome amplification with phi29 DNA polymerase. Biochem Biophys Res Commun 2005;329: 219-23.
26. Umetani N, Takeuchi H, Fujimoto A, Shinozaki M, Bilchik AJ, Hoon DS. Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis. Clin Cancer Res 2004;10:7475-83.