The serological evidence in humans supports a negligible risk of zoonotic infection from porcine circovirus type 2

Biologicals

Volumn 41, Issue 6, 2013, Pages 430-434

  Burbelo, Peter D ^a   Ragheb, Jack A ^b   Kapoor, Amit ^c   Zhang, Yanjin ^d  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d UNIVERSITY OF MARYLAND   (United States)

Author keywords

Antibodies; PCV 2; Porcine circovirus; Porcine derived supplements; Seroepidemiology

Indexed keywords

ADULT; ARTICLE; BLOOD DONOR; BLOOD SAMPLING; CIRCOVIRUS; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; GENE SEQUENCE; HIGH RISK PATIENT; HUMAN; HUMORAL IMMUNITY; INFECTION RISK; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET TRANSPLANTATION; PORCINE CIRCOVIRUS TYPE 2; PRIORITY JOURNAL; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SEQUENCE ALIGNMENT; SEROLOGY; VIRUS CAPSID; VIRUS GENE; ZOONOSIS;

BOVINAE; EQUIDAE; MIRIDAE; PORCINE CIRCOVIRUS; PORCINE CIRCOVIRUS 2; SUIDAE; SUS;

ANTIBODIES; PCV-2; PORCINE CIRCOVIRUS; PORCINE-DERIVED SUPPLEMENTS; SEROEPIDEMIOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, VIRAL; CAPSID PROTEINS; CATTLE; CERCOPITHECUS AETHIOPS; CIRCOVIRIDAE INFECTIONS; CIRCOVIRUS; COS CELLS; HORSES; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOASSAY; LUCIFERASES; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; RISK FACTORS; SEQUENCE HOMOLOGY, AMINO ACID; SWINE; ZOONOSES;

EID: 84888011328     PISSN: 10451056     EISSN: 10958320     Source Type: Journal    
DOI: 10.1016/j.biologicals.2013.09.005     Document Type: Article

References (30)

1. Mankertz A. Molecular interactions of porcine circoviruses type 1 and type 2 with its host. Virus Res 2012, 164:54-60.
2. Fenaux M., Halbur P.G., Gill M., Toth T.E., Meng X.J. Genetic characterization of type 2 porcine circovirus (PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential PCR-restriction fragment length polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2. JClin Microbiol 2000, 38:2494-2503.
3. Tischer I., Mields W., Wolff D., Vagt M., Griem W. Studies on epidemiology and pathogenicity of porcine circovirus. Arch Virol 1986, 91:271-276.
4. Ramamoorthy S., Meng X.J. Porcine circoviruses: a minuscule yet mammoth paradox. Anim Health Res Rev 2009, 10:1-20.
5. Li L., Kapoor A., Slikas B., Bamidele O.S., Wang C., Shaukat S., et al. Multiple diverse circoviruses infect farm animals and are commonly found in human and chimpanzee feces. JVirol 2010, 84:1674-1682.
6. Blinkova O., Rosario K., Li L., Kapoor A., Slikas B., Bernardin F., et al. Frequent detection of highly diverse variants of cardiovirus, cosavirus, bocavirus, and circovirus in sewage samples collected in the United States. JClin Microbiol 2009, 47:3507-3513.
7. Victoria J.G., Wang C., Jones M.S., Jaing C., McLoughlin K., Gardner S., et al. Viral nucleic acids in live-attenuated vaccines: detection of minority variants and an adventitious virus. JVirol 2010, 84:6033-6040.
8. Baylis S.A., Finsterbusch T., Bannert N., Blumel J., Mankertz A. Analysis of porcine circovirus type 1 detected in Rotarix vaccine. Vaccine 2011, 29:690-697.
9. Gilliland S.M., Forrest L., Carre H., Jenkins A., Berry N., Martin J., et al. Investigation of porcine circovirus contamination in human vaccines. Biologicals 2012, 40:270-277.
10. McClenahan S.D., Krause P.R., Uhlenhaut C. Molecular and infectivity studies of porcine circovirus in vaccines. Vaccine 2011, 29:4745-4753.
11. Tischer I., Bode L., Apodaca J., Timm H., Peters D., Rasch R., et al. Presence of antibodies reacting with porcine circovirus in sera of humans, mice, and cattle. Arch Virol 1995, 140:1427-1439.
12. Ellis J.A., Wiseman B.M., Allan G., Konoby C., Krakowka S., Meehan B.M., et al. Analysis of seroconversion to porcine circovirus 2 among veterinarians from the United States and Canada. JAm Vet Med Assoc 2000, 217:1645-1646.
13. Allan G.M., McNeilly F., McNair I., Curran M.D., Walker I., Ellis J., et al. Absence of evidence for porcine circovirus type 2 in cattle and humans, and lack of seroconversion or lesions in experimentally infected sheep. Arch Virol 2000, 145:853-857.
14. Burbelo P.D., Ching K.H., Bush E.R., Han B.L., Iadarola M.J. Antibody-profiling technologies for studying humoral responses to infectious agents. Expert Rev Vaccines 2010, 9:567-578.
15. Burbelo P.D., Ching K.H., Mattson T.L., Light J.S., Bishop L.R., Kovacs J.A. Rapid antibody quantification and generation of whole proteome antibody response profiles using LIPS (luciferase immunoprecipitation systems). Biochem Biophys Res Commun 2007, 352:889-895.
16. Groth C.G., Korsgren O., Tibell A., Tollemar J., Moller E., Bolinder J., et al. Transplantation of porcine fetal pancreas to diabetic patients. Lancet 1994, 344:1402-1404.
17. Burbelo P.D., Ching K.H., Klimavicz C.M., Iadarola M.J. Antibody profiling by luciferase immunoprecipitation systems (LIPS). JVis Exp 2009, 32.
18. Borowitz D., Durie P.R., Clarke L.L., Werlin S.L., Taylor C.J., Semler J., et al. Gastrointestinal outcomes and confounders in cystic fibrosis. JPediatr Gastroenterol Nutr 2005, 41:273-285.
19. Shibata I., Okuda Y., Yazawa S., Ono M., Sasaki T., Itagaki M., et al. PCR detection of Porcine circovirus type 2 DNA in whole blood, serum, oropharyngeal swab, nasal swab, and feces from experimentally infected pigs and field cases. JVet Med Sci 2003, 65:405-408.
20. Marcekova Z., Psikal I., Kosinova E., Benada O., Sebo P., Bumba L. Heterologous expression of full-length capsid protein of porcine circovirus 2 in Escherichia coli and its potential use for detection of antibodies. JVirol Methods 2009, 162:133-141.
21. Puvanendiran S., Stone S., Yu W., Johnson C.R., Abrahante J., Jimenez L.G., et al. Absence of porcine circovirus type 1 (PCV1) and high prevalence of PCV 2 exposure and infection in swine finisher herds. Virus Res 2011, 157:92-98.
22. Jittimanee S., Nuntawan Na Ayudhya S., Kedkovid R., Teankum K., Suradhat S., Thanawongnuwech R. An indirect enzyme-linked immunosorbent assay using a recombinant truncated capsid protein of Porcine circovirus-2. JVet Diagn Invest 2012, 24:1129-1132.
23. Nayar G.P., Hamel A.L., Lin L., Sachvie C., Grudeski E., Spearman G. Evidence for circovirus in cattle with respiratory disease and from aborted bovine fetuses. Can Vet J 1999, 40:277-278.
24. Kappe E.C., Halami M.Y., Schade B., Alex M., Hoffmann D., Gangl A., et al. Bone marrow depletion with haemorrhagic diathesis in calves in Germany: characterization of the disease and preliminary investigations on its aetiology. Berl Munch Tierarztl Wochenschr 2010, 123:31-41.
25. Ellis J.A., Konoby C., West K.H., Allan G.M., Krakowka S., McNeilly F., et al. Lack of antibodies to porcine circovirus type 2 virus in beef and dairy cattle and horses in western Canada. Can Vet J 2001, 42:461-464.
26. Rodriguez-Arrioja G.M., Segales J., Domingo M., Plana-Duran J. Lack of PCV-2 infection in non-porcine species in Spain. Vet Rec 2003, 153:371-372.
27. Liu E., Eisenbarth G.S. Accepting clocks that tell time poorly: fluid-phase versus standard ELISA autoantibody assays. Clin Immunol 2007, 125:120-126.
28. Hattermann K., Maerz A., Slanina H., Schmitt C., Mankertz A. Assessing the risk potential of porcine circoviruses for xenotransplantation: consensus primer-PCR-based search for a human circovirus. Xenotransplantation 2004, 11:547-550.
29. Kapoor A., Dubovi E.J., Henriquez-Rivera J.A., Lipkin W.I. Complete genome sequence of the first canine circovirus. JVirol 2012, 86:7018.
30. Todd D. Avian circovirus diseases: lessons for the study of PMWS. Vet Microbiol 2004, 98:169-174.