Chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells treated by GSK-3 inhibitors

Histochemistry and Cell Biology

Volumn 140, Issue 6, 2013, Pages 623-633

  Eslaminejad, Mohamadreza Baghaban ^a   Karimi, Negar ^a   Shahhoseini, Maryam ^a  

^a ROYAN INSTITUTE FOR REPRODUCTIVE BIOMEDICINE   (Iran)

Author keywords

Chondrogenesis; GSK 3 inhibitors; Human mesenchymal stem cells; Wnt pathway

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; AGGRECAN; AXIN; BETA CATENIN; COLLAGEN TYPE 2; GLYCOSAMINOGLYCAN; LITHIUM CHLORIDE; TRANSCRIPTION FACTOR SOX9; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3; GLYCOGEN SYNTHASE KINASE 3; INDOLE DERIVATIVE; MALEIMIDE DERIVATIVE;

ARTICLE; BONE MARROW CELL; CARTILAGE CELL; CARTILAGE MATRIX; CELL CULTURE; CELL DIFFERENTIATION; CHONDROGENESIS; DOWN REGULATION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUPPLEMENTATION; UPREGULATION; WNT SIGNALING PATHWAY; ANTAGONISTS AND INHIBITORS; CARTILAGE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; MESENCHYMAL STROMA CELL; METABOLISM; STRUCTURE ACTIVITY RELATION;

BONE MARROW CELLS; CARTILAGE; CELL DIFFERENTIATION; CELLS, CULTURED; CHONDROCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INDOLES; LITHIUM CHLORIDE; MALEIMIDES; MESENCHYMAL STROMAL CELLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84888000534     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-013-1121-x     Document Type: Article

References (47)

1. Benya PD, Shaffer JD (1982) Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 30:215-224
2. Besschetnova TY, Kolpakova-Hart E, Guan Y, Zhou J, Olsen BR, Shah JV (2010) Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation. Curr Biol 20:182-187
3. Bosnakovski D, Mizuno M, Kim G, Ishiguro T, Okumura M, Iwanaga T, Kadosawa T, Fujinaga T (2004) Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells in pellet culture system. Exp Hematol 32:502-509
4. Brighton CT, Sugioka Y, Hunt RM (1973) Cytoplasmic structures of the epiphyseal plate chondrocytes: quantitative evaluation using electron micrographs of rat costochondral junctions with special reference to the fate of hypertrophic cells. J Bone Joint Surg 55A:771-1973
5. Coghlan MP, Culbert AA, Cross DA, Corcoran SL, Yates JW, Pearce NJ, Rausch OL, Murphy GJ, Carter PS, Roxbee Cox L, Mills D, Brown MJ, Haigh D, Ward RW, Smith DG, Murray KJ, Reith AD, Holder JC (2000) Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 7:793-803
6. Darling EM, Athanasiou KA (2003a) Biomechanical strategies for articular cartilage regeneration. Ann Biomed Eng 31:1114-1124
7. Darling EM, Athanasiou KA (2003b) Articular cartilage bioreactors and bioprocesses. Tissue Eng 9:9-26
8. de Boer J, Wang HJ, Van Blitterswijk C (2004a) Effects of Wnt signaling on proliferation and differentiation of human mesenchymal stem cells. Tissue Eng 10:393-401
9. de Boer J, Siddappa R, Gaspar C, van Apeldoorn A, Fodde R, van Blitterswijk C (2004b) Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells. Bone 34:818-826
10. Eslaminejad MB, Nikmahzar A, Piriea A (2006a) The structure of human mesenchymal stem cells differentiated into cartilage in micro mass culture system. Yakhteh Med J 3:162-171
11. Eslaminejad MB, Nikmahzar A, Thagiyar L, Nadri S, Massumi M (2006b) Murine mesenchymal stem cells isolated by low density primary culture system. Dev Growth Diff 48:361-370
12. Friedenstein AJ, Chailakhjan RK, Lalykina KS (1970) The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet 3:393-403
13. Friedenstein AJ, Gorskaja JF, Kulagina NN (1976) Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol 4:267-274
14. Gurvich N, Klein PS (2002) Lithium and valproic acid: parallels and contrasts in diverse signaling contexts. Pharmacol Ther 96:45-66
15. Horton WE, Yagi R, Laverty D, Weiner S (2005) Overview of studies comparing human normal cartilage with minimal and advanced osteoarthritic cartilage. Clin Exp Rheumatol 23:103-112
16. Imai K, Takaoka A (2006) Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 6:714-727
17. Indrawattana N, Chen G, Tadokoro M, Shann LH, Ohgushi H, Tateishi T, Tanaka J, Bunyaratvej A (2004) Growth factor combination for chondrogenic induction from human mesenchymal stem cell. Biochem Biophys Res Commun 320:914-919
18. Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU (1998) In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 238:65-72
19. Kapadia RM, Guntur AR, Reinhold MI, Naski MC (2005) Glycogen synthase kinase 3 controls endochondral bone development: contribution of fibroblast growth factor 18. Dev Biol 285:496-507
20. Kawata K, Kubota S, Eguchi T, Moritani NH, Shimo T, Kondo S, Nishida T, Minagi S, Takigawa M (2010) Role of the low-density lipoprotein receptor-related protein-1 in regulation of chondrocyte differentiation. J Cell Physiol 222:138-148
21. Kirton JP, Crofts NJ, George SJ, Brennan K, Canfield AE (2007) Wnt/beta-catenin signaling stimulates chondrogenic and inhibits adipogenic differentiation of pericytes: potential relevance to vascular disease? Circ Res 101:581-589
22. Klein PS, Melton DA (1996) A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA 93:8455-8459
23. Knight MM, McGlashan SR, Garcia M, Jensen CG, Poole CA (2009) Articular chondrocytes express connexin 43 hemichannels and P2 receptors: a putative mechanoreceptor complex involving the primary cilium? J Anat 214:275-283
24. Letamendia A, Labbé E, Attisano L (2001) Transcriptional regulation by Smads: crosstalk between the TGF-beta and Wnt pathways. J Bone Joint Surg Am 83:31-39
25. Lu XL, Mow VC (2008) Biomechanics of articular cartilage and determination of material properties. Med Sci Sports Exerc 40:193-199
26. Mandelbaum B, Waddell D (2005) Etiology and pathophysiology of osteoarthritis. Orthopedics 28:s207-s214
27. Miyoshi K, Kasahara K, Miyazaki I, Asanuma M (2009) Lithium treatment elongates primary cilia in the mouse brain and in cultured cells. Biochem Biophys Res Commun 388:757-762
28. Mwale F, Girard-Lauriault PL, Wang HT, Lerouge S, Antoniou J, Wertheimer MR (2006a) Suppression of genes related to hypertrophy and osteogenesis in committed human mesenchymal stem cells cultured on novel nitrogen-rich plasma polymer coatings. Tissue Eng 12:2639-2647
29. Mwale F, Stachura D, Roughley P, Antoniou J (2006b) Limitations of using aggrecan and type X collagen as markers of chondrogenesis in mesenchymal stem cell differentiation. J Orthop Res 24:1791-1798
30. Nemoto T, Kanai T, Yanagita T, Satoh S, Maruta T, Yoshikawa N, Kobayashi H, Wada A (2008) Regulation of Akt mRNA and protein levels by glycogen synthase kinase-3beta in adrenal chromaffin cells: effects of LiCl and SB216763. Eur J Pharmacol 586:82-89
31. Neth P, Ciccarella M, Egea V, Hoelters J, Jochum M, Ries C (2006) Wnt signaling regulates the invasion capacity of human mesenchymal stem cells. Stem Cells 24:1892-1903
32. Nöth UM, Steinert AF, Tuan RS (2008) Technology insight: adult mesenchymal stem cells for osteoarthritis therapy. Nat Clin Pract Rheumatol 4:371-380
33. Ou Y, Ruan Y, Cheng M, Moser JJ, Rattner JB, van der Hoorn FA (2009) Adenylate cyclase regulates elongation of mammalian primary cilia. Exp Cell Res 315:2802-2817
34. Ozawa K, Sato K, Oh I, Ozaki K, Uchibori R, Obara Y, Kikuchi Y, Ito T, Okada T, Urabe M, Mizukami H, Kume A (2008) Cell and gene therapy using mesenchymal stem cells (MSCs). J Autoimmun 30:121-127
35. Pelttari K, Winter A, Steck E, Goetzke K, Hennig T, Ochs BG, Aigner T, Richter W (2006) Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum 54:3254-3266
36. Prockop DJ (1997) Marrow stromal cells as stemcells for nonhematopoietic tissue. Science 276:71-74
37. Satir P, Christensen ST (2007) Overview of structure and function of mammalian cilia. Annu Rev Physiol 69:377-400
38. Schnabel M, Marlovits S, Eckhoff G, Fichtel I, Gotzen L, Vécsei V, Schlegel J (2002) Dedifferentiation-associated changes in morphology and gene expression in primary human articular chondrocytes in cell culture. Osteoarthritis Cartilage 10:62-70
39. Schulz RM, Bader A (2007) Cartilage tissue engineering and bioreactor systems for the cultivation and stimulation of chondrocytes. Eur Biophys J 36:539-568
40. Sekiya I, Vuoristo JT, Larson BL, Prockop DJ (2002) In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis. Proc Natl Acad Sci USA 99:4397-4402
41. Stambolic V, Ruel L, Woodgett JR (1996) Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Bio 6:1664-1668
42. Stefan H, Claire LK (2007) Wnt signalling: variety at the core. J Cell Sci 120:385-393
43. Tapp H, Deepe R, Ingram JA, Kuremsky M, Hanley EN Jr, Gruber HE (2008) Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix. Arthritis Res Ther 10:R89
44. Worster AA, Brower-Toland BD, Fortier LA, Bent SJ, Williams J, Nixon AJ (2001) Chondrocytic differentiation of mesenchymal stem cells sequentially exposed to transforming growth factor-beta1 in monolayer and insulin-like growth factor-I in a three-dimensional matrix. J Orthop Res 19:738-749
45. Yoo JU, Barthel TS, Nishimura K, Solchaga L, Caplan AI, Goldberg VM, Johnstone B (1998) The chondrogenic potential of human bone-marrow-derived mesenchymal progenitor cells. J Bone Joint Surg Am 80:1745-1757
46. Yoshino JE, DeVries GH (1987) Effect of lithium on Schwann cell proliferation stimulated by axolemma- and myelin-enriched fractions. J Neurochem 48:1270-1277
47. Zhou S, Eid K, Glowacki J (2004) Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells. J Bone Miner Res 19:463-470