Elevation of neutrophil gelatinase-associated lipocalin (NGAL) in non-azotemic dogs with urinary tract infection

Research in Veterinary Science

Volumn 95, Issue 3, 2013, Pages 1181-1185

  Daure, Evence ^a   Belanger, Marie C ^b   Beauchamp, Guy ^b   Lapointe, Catherine ^b  

^a DMV Veterinary Center   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Biomarker; Culture; Dog; Kidney; NGAL; UTI

Indexed keywords

CREATININE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN;

AGE; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL STRAIN; CITROBACTER; CONTROLLED STUDY; DOG; ENTEROCOCCUS; ESCHERICHIA COLI; FEMALE; MALE; NONHUMAN; PREDICTIVE VALUE; PROTEIN URINE LEVEL; PROTEUS; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; STAPHYLOCOCCUS; UREMIA; URINARY TRACT INFECTION; URINE CULTURE;

CANIS FAMILIARIS;

BIOMARKER; CULTURE; DOG; KIDNEY; NGAL; UTI;

ACUTE-PHASE PROTEINS; ANIMALS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DOG DISEASES; DOGS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; LIPOCALINS; MALE; PROTO-ONCOGENE PROTEINS; URINARY TRACT INFECTIONS;

EID: 84887997165     PISSN: 00345288     EISSN: 15322661     Source Type: Journal    
DOI: 10.1016/j.rvsc.2013.09.002     Document Type: Article

References (41)

1. Anonymous, 2009. International renal interest society staging system. Available from:. http://www.iriskidney.com/pdf/IRIS2009_Staging_CKD.pdf.
2. Bao G., Clifton M., Hoette T.M., Mori K., Deng S.X., Qiu A., Viltard M., Williams D., Paragas N., Leete T., Kulkarni R., Li X., Lee B., Kalandadze A., Ratner A.J., Pizarro J.C., Schmidt-Ott K.M., Landry D.W., Raymond K.N., Strong R.K., Barasch J. Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. Nature Chemical Biology 2010, 6:602-609.
3. Bartges J.W. Diagnosis of urinary tract infections. Veterinary Clinics of North America: Small Animal Practice 2004, 34:923-933.
4. Bolignano D., Lacquaniti A., Coppolino G., Donato V., Campo S., Fazio M.R., Nicocia G., Buemi M. Neutrophil gelatinase-associated lipocalin (NGAL) and progression of chronic kidney disease. Clinical Journal of the American Society of Nephrology 2009, 4:337-344.
5. Borregaard N., Cowland J.B. Neutrophil gelatinase-associated lipocalin, a siderophore-binding eukaryotic protein. BioMetals 2006, 19:211-215.
6. Cai L., Rubin J., Han W., Venge P., Xu S. The origin of multiple molecular forms in urine of HNL/NGAL. Clinical Journal of the American Society of Nephrology 2010, 5:2229-2235.
7. Cobrin A, Blois S, Abrams-Ogg ACG, Kruth S, Dewey C. 2012. Serum and urine neutrophil gelatinase-associated lipocalin (NGAL) concentration in healthy dogs and dogs with chronic kidney disease. Advanced Renal Therapies Symposium, New York, p. 131. Available from:. http://www.amcny.org/sites/default/files/ARTS%202012%20Proceedings.pdf.
8. Decavele A.S., Dhondt L., De Buyzere M.L., Delanghe J.R. Increased urinary neutrophil gelatinase associated lipocalin in urinary tract infections and leukocyturia. Clinical Chemistry and Laboratory Medicine 2011, 49:999-1003.
9. Devarajan P. Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease. Scandinavian Journal of Clinical and Laboratory Investigation Supplement 2008, 241:89-94.
10. Devarajan P. Review: neutrophil gelatinase-associated lipocalin: a troponin-like biomarker for human acute kidney injury. Nephrology (Carlton) 2010, 15:419-428.
11. Ettinger S.J., Feldman E.C. Textbook of Veterinary Internal Medicine 2010, Saunders, Missouri, St. Louis, pp. 1755-3026. Seventh ed.
12. Flo T.H., Smith K.D., Sato S., Rodriguez D.J., Holmes M.A., Strong R.K., Akira S., Aderem A. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 2004, 432:917-921.
13. Haase M., Bellomo R., Devarajan P., Schlattmann P., Haase-Fielitz A. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. American Journal of Kidney Diseases 2009, 54:1012-1024.
14. Haase M., Devarajan P., Haase-Fielitz A., Bellomo R., Cruz D.N., Wagener G., Krawczeski C.D., Koyner J.L., Murray P., Zappitelli M., Goldstein S.L., Makris K., Ronco C., Martensson J., Martling C.R., Venge P., Siew E., Ware L.B., Ikizler T.A., Mertens P.R. The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. Journal of the American College of Cardiology 2011, 57:1752-1761.
15. Hatipoglu S., Sevketoglu E., Gedikbasi A., Yilmaz A., Kiyak A., Mulazimoglu M., Aydogan G., Ozpacaci T. Urinary MMP-9/NGAL complex in children with acute cystitis. Pediatric Nephrology 2011, 26:1263-1268.
16. Ichino M., Kuroyanagi Y., Kusaka M., Mori T., Ishikawa K., Shiroki R., Kurahashi H., Hoshinaga K. Increased urinary neutrophil gelatinase associated lipocalin levels in a rat model of upper urinary tract infection. Journal of Urology 2009, 181:2326-2331.
17. Kai K., Yamaguchi T., Yoshimatsu Y., Kinoshita J., Teranishi M., Takasaki W. Neutrophil gelatinase-associated lipocalin, a sensitive urinary biomarker of acute kidney injury in dogs receiving gentamicin. Journal of Toxicological Sciences 2013, 38:269-277.
18. Lee Y.J., Hu Y.Y., Lin Y.S., Chang C.T., Lin F.Y., Wong M.L., Kuo-Hsuan H., Hsu W.L. Urine neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute canine kidney injury. BMC Veterinary Research 2012, 8:248. 10.1186/1746-6148-8-248.
19. Lees G.E. Bacterial urinary tract infections. Veterinary Clinics of North America: Small Animal Practice 1996, 26:297-304.
20. Ling G.V. Therapeutic strategies involving antimicrobial treatment of the canine urinary tract. Journal of the American Veterinary Medical Association 1984, 185:1162-1164.
21. Ling G.V., Norris C.R., Franti C.E., Eisele P.H., Johnson D.L., Ruby A.L., Jang S.S. Interrelations of organism prevalence, specimen collection method, and host age, sex, and breed among 8,354 canine urinary tract infections (1969-1995). Journal of Veterinary Internal Medicine 2001, 15:341-347.
22. Makris K., Markou N., Evodia E., Dimopoulou E., Drakopoulos I., Ntetsika K., Rizos D., Baltopoulos G., Haliassos A. Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients. Clinical Chemistry and Laboratory Medicine 2009, 47:79-82.
23. Mehta R.L. Biomarker explorations in acute kidney injury: the journey continues. Kidney International 2011, 80:332-334.
24. Miethke M., Skerra A. Neutrophil gelatinase-associated lipocalin expresses antimicrobial activity by interfering with l-norepinephrine-mediated bacterial iron acquisition. Antimicrobial Agents and Chemotherapy 2010, 54:1580-1589.
25. Mishra J., Mori K., Ma Q., Kelly C., Yang J., Mitsnefes M., Barasch J., Devarajan P. Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. Journal of the American Society of Nephrology 2004, 15:3073-3082.
26. Mori K., Nakao K. Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage. Kidney International 2007, 71:967-970.
27. Nabity M.B., Lees G.E., Cianciolo R., Boggess M.M., Steiner J.M., Suchodolski J.S. Urinary biomarkers of renal disease in dogs with X-linked hereditary nephropathy. Journal of Veterinary Internal Medicine 2012, 26:282-293.
28. Nickolas T.L., O'Rourke M.J., Yang J., Sise M.E., Canetta P.A., Barasch N., Buchen C., Khan F., Mori K., Giglio J., Devarajan P., Barasch J. Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Annals of Internal Medicine 2008, 148:810-819.
29. Schmidt-Ott K.M., Mori K., Kalandadze A., Li J.Y., Paragas N., Nicholas T., Devarajan P., Barasch J. Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia. Current Opinion in Nephrology and Hypertension 2006, 15:442-449.
30. Schmidt-Ott K.M., Mori K., Li J.Y., Kalandadze A., Cohen D.J., Devarajan P., Barasch J. Dual action of neutrophil gelatinase-associated lipocalin. Journal of the American Society of Nephrology 2007, 18:407-413.
31. Seguin M.A., Vaden S.L., Altier C., Stone E., Levine J.F. Persistent urinary tract infections and reinfections in 100 dogs (1989-1999). Journal of Veterinary Internal Medicine 2003, 17:622-631.
32. Singer E., Elger A., Elitok S., Kettritz R., Nickolas T.L., Barasch J., Luft F.C., Schmidt-Ott K.M. Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes. Kidney International 2011, 80:405-414.
33. Sirota J.C., Klawitter J., Edelstein C.L. Biomarkers of acute kidney injury. Journal of Toxicology 2011, 2011:328120.
34. Swenson C.L., Boisvert A.M., Kruger J.M., Gibbons-Burgener S.N. Evaluation of modified Wright-staining of urine sediment as a method for accurate detection of bacteriuria in dogs. Journal of the American Veterinary Medical Association 2004, 224:1282-1289.
35. Thomsen M.K., Svane L.C., Poulsen P.H. Canine urinary tract infection. Detection, prevalence and therapeutic consequences of bacteriuria. Nordisk Veterinaermedicin 1986, 38:394-402.
36. Tivapasi M.T., Hodges J., Byrne B.A., Christopher M.M. Diagnostic utility and cost-effectiveness of reflex bacterial culture for the detection of urinary tract infection in dogs with low urine specific gravity. Veterinary Clinical Pathology 2009, 38:337-342.
37. Tomonaga Y., Szucs T., Ambuhl P., Nock S., Risch M., Risch L. Insights on urinary NGAL obtained in a primary care setting. Clinica Chimica Acta 2012, 413:733-739.
38. Torres S.M., Diaz S.F., Nogueira S.A., Jessen C., Polzin D.J., Gilbert S.M., Horne K.L. Frequency of urinary tract infection among dogs with pruritic disorders receiving long-term glucocorticoid treatment. Journal of the American Veterinary Medical Association 2005, 227:239-243.
39. Urbschat A., Obermuller N., Haferkamp A. Biomarkers of kidney injury. Biomarkers 2011, 16(Suppl. 1):S22-30.
40. Xu S.Y., Petersson C.G., Carlson M., Venge P. The development of an assay for human neutrophil lipocalin (HNL)-to be used as a specific marker of neutrophil activity in vivo and vitro. Journal of Immunological Methods 1994, 171:245-252.
41. Yilmaz A., Sevketoglu E., Gedikbasi A., Karyagar S., Kiyak A., Mulazimoglu M., Aydogan G., Ozpacaci T., Hatipoglu S. Early prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin. Pediatric Nephrology 2009, 24:2387-2392.