Chemical probe identification platform for orphan GPCRs using focused compound screening: GPR39 as a case example

ACS Medicinal Chemistry Letters

Volumn 4, Issue 11, 2013, Pages 1079-1084

  Boehm, Markus ^a   Hepworth, David ^a   Loria, Paula M ^a   Norquay, Lisa D ^a   Filipski, Kevin J ^a   Chin, Janice E ^a   Cameron, Kimberly O ^a   Brenner, Martin ^a   Bonnette, Peter ^a   Cabral, Shawn ^a   Conn, Edward ^a   Ebner, David C ^a   Gautreau, Denise ^a   Hadcock, John ^a   Lee, Esther C Y ^a   Mathiowetz, Alan M ^a   Morin, Michelle ^a   Rogers, Lucy ^a   Smith, Aaron ^a   Vanvolkenburg, Maria ^a   Carpino, Philip A ^a   more..

^a PFIZER INC   (United States)

Author keywords

chemical probe identification platform; GPCR focused chemical library; GPR39; Orphan GPCRs

Indexed keywords

EXENDIN 4; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 39; G PROTEIN COUPLED RECEPTOR 39 AGONIST; GHRELIN; ORPHAN G PROTEIN COUPLED RECEPTOR; PIPERAZINE DERIVATIVE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; DIABETES MELLITUS; GENETIC ASSOCIATION; GENETIC LINKAGE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INSULIN RELEASE; LIPOPHILICITY; METABOLIC DISORDER; NONHUMAN; PANCREAS ISLET BETA CELL; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SERUM RESPONSIVE ELEMENT; SIGNAL TRANSDUCTION;

EID: 84887984892     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400275z     Document Type: Article

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