Ethynyl side chain hydration during synthesis and workup of "clickable" oligonucleotides: Bypassing acetyl group formation by triisopropylsilyl protection

Journal of Organic Chemistry

Volumn 78, Issue 22, 2013, Pages 11271-11282

  Ingale, Sachin A ^a,b   Mei, Hui ^a,b   Leonard, Peter ^a   Seela, Frank ^a,b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF OSNABRÜCK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL DERIVATIVES; ACETYL GROUPS; BASIC CONDITIONS; DESILYLATION; MODIFIED NUCLEOSIDES; OLIGONUCLEOTIDE SYNTHESIS; PHOSPHODIESTERS; SIDE PRODUCTS;

BIOMOLECULES; CHAINS; ENZYMATIC HYDROLYSIS; HYDRATION; MASS SPECTROMETRY;

OLIGONUCLEOTIDES;

ACETIC ACID DERIVATIVE; DEZAGUANINE; ETHYNYL GROUP; FUNCTIONAL GROUP; NUCLEIC ACID BASE; NUCLEOSIDE DERIVATIVE; OLIGONUCLEOTIDE; PHOSPHORAMIDOUS ACID DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CLICK CHEMISTRY; DEPROTECTION REACTION; DESILYLATION; HYDRATION; HYDROLYSIS; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; SOLID PHASE SYNTHESIS; SYNTHESIS;

CROSS-LINKING REAGENTS; GUANINE; HYDROLYSIS; MOLECULAR CONFORMATION; OLIGONUCLEOTIDES; PYRIMIDINES; SILANES; WATER;

EID: 84887951802     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo401780u     Document Type: Article

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