The association of interleukin 6-634C/G polymorphism with left atrial thrombus and severe spontaneous echocontrast in patients with atrial fibrillation

Clinical and Applied Thrombosis/Hemostasis

Volumn 19, Issue 6, 2013, Pages 673-678

  Deng, Xin Tao ^a   Jiang, Min Hui ^b   Zhu, Jian Hua ^b   Ge, Li Jun ^c   Guo, Jing ^d   Gao, Shu Ping ^c   Zheng, Jin Guo ^a   Luan, Hong ^c   Shi, Gui Liang ^a   Wang, Ru Xing ^e   Shi, Hai Feng ^f   Pan, Min ^b  

^a Xinghua People's Hospital   (China)

^b NANTONG UNIVERSITY   (China)

^c Ningxia People's Hospital   (China)

^d Soochow University   (China)

^e WUXI PEOPLE S HOSPITAL AFFILIATED TO NANJING MEDICAL UNIVERSITY   (China)

^f SHANGHAI CHEST HOSPITAL   (China)

Author keywords

atrial fibrillation; Chinese; genetic polymorphism; interleukin 6; left atrium; thrombus

Indexed keywords

INTERLEUKIN 6;

ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; CEREBROVASCULAR ACCIDENT; CHINESE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HEART ATRIUM FIBRILLATION; HEART ATRIUM THROMBOSIS; HEART LEFT ATRIUM; HUMAN; IMAGE QUALITY; MAJOR CLINICAL STUDY; MALE; MORBIDITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SPONTANEOUS ECHOCONTRAST; TRANSESOPHAGEAL ECHOCARDIOGRAPHY;

ATRIAL FIBRILLATION; CHINESE; GENETIC POLYMORPHISM; INTERLEUKIN 6; LEFT ATRIUM; THROMBUS;

ATRIAL FIBRILLATION; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; ECHOCARDIOGRAPHY, TRANSESOPHAGEAL; FEMALE; GENOTYPE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; THROMBOSIS;

EID: 84887947629     PISSN: 10760296     EISSN: 19382723     Source Type: Journal    
DOI: 10.1177/1076029612457706     Document Type: Article

References (45)

1. Go AS, Hylek EM, Phillips KA, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA. 2001 ; 285 (18). 2370-2375
2. Pan M, Zhu JH, Jiang WP, et al. Inflammation: a possible pathogenic link to atrial fibrillation. Med Hypotheses. 2006 ; 67 (6). 1305-1307
3. Camm AJ, Kirchhof P, Lip GY, et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J. 2010 ; 31 (19). 2369-2429
4. Musial J, Brzezinska-Kolarz B, Zolcinski M, Lelakowski J, Szczeklik A. Ex vivo thrombin generation in patients with venous thromboembolic disease or atrial fibrillation on long-term oral anticoagulation. Clin Appl Thromb Hemost. 2010 ; 16 (6). 614-621
5. Nakamura Y, Nakamura K, Fukushima-Kusano K, et al. Tissue factor expression in atrial endothelia associated with nonvalvular atrial fibrillation: possible involvement in intracardiac thrombogenesis. Thromb Res. 2003 ; 111 (3). 137-142
6. Gao SP, Deng XT, Ge LJ, et al. Is inflammation linked to thrombogenesis in atrial fibrillation. Int J Cardiol. 2011 ; 149 (2). 260-261
7. Ridker PM, Rifai N, Stampfer MJ, Hennekens CH. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation. 2000 ; 101 (15). 1767-1772
8. Chen F, Guo J, Gao SP, et al. Interleukin-6-634C>G polymorphism in hypertensive patients with and without left ventricular hypertrophy. Mol Med Rep. 2011 ; 4 (2). 283-289
9. Pan M, Gao SP, Jiang MH, Guo J, Zheng JG, Zhu JH. Interleukin 6 promoter polymorphisms in normal Han Chinese population: frequencies and effects on inflammatory markers. J Investig Med. 2011 ; 59 (2). 272-276
10. Conway DS, Buggins P, Hughes E, Lip GY. Prognostic significance of raised plasma levels of interleukin-6 and C-reactive protein in atrial fibrillation. Am Heart J. 2004 ; 148 (3). 462-466
11. Roldan V, Marin F, Martinez JG, Garcia-Herola A, Sogorb F, Lip GY. Relation of interleukin-6 levels and prothrombin fragment 1+2 to a point-based score for stroke risk in atrial fibrillation. Am J Cardiol. 2005 ; 95 (7). 881-882
12. Smith AJ, D'Aiuto F, Palmen J, et al. Association of serum interleukin-6 concentration with a functional IL6 -6331T>C polymorphism. Clin Chem. 2008 ; 54 (5). 841-850
13. Pantsulaia I, Trofimov S, Kobyliansky E, Livshits G. Genetic and environmental influences on IL-6 and TNF-alpha plasma levels in apparently healthy general population. Cytokine. 2002 ; 19 (3). 138-146
14. Cardellini M, Perego L, D'Adamo M, et al. C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance. Diabetes Care. 2005 ; 28 (8). 2007-2012
15. Cherel M, Campion L, Bezieau S, et al. Molecular screening of interleukin-6 gene promoter and influence of -174G/C polymorphism on breast cancer. Cytokine. 2009 ; 47 (3). 214-223
16. Terry CF, Loukaci V, Green FR. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem. 2000 ; 275 (24). 18138-18144
17. Koh SJ, Jang Y, Hyun YJ, et al. Interleukin-6 (IL-6)-572C - >G promoter polymorphism is associated with type 2 diabetes risk in Koreans. Clin Endocrinol (Oxf). 2009 ; 70 (2). 238-244
18. Saijo Y, Yoshioka E, Fukui T, et al. Effects of the interaction between interleukin-6 -634C/G polymorphism and smoking on serum C-reactive protein concentrations. Hypertens Res. 2007 ; 30 (7). 593-599
19. Gao SP, Pan M, Chen C, et al. The G to A polymorphism at -597 of the interleukin-6 gene is extremely rare in southern Han Chinese. Cytokine. 2011 ; 55 (1). 1-3
20. Humphries SE, Luong LA, Ogg MS, Hawe E, Miller GJ. The interleukin-6 -174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men. Eur Heart J. 2001 ; 22 (24). 2243-2252
21. Hamid YH, Rose CS, Urhammer SA, et al. Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes. Diabetologia. 2005 ; 48 (2). 251-260
22. Antonicelli R, Olivieri F, Bonafe M, et al. The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients. Int J Cardiol. 2005 ; 103 (3). 266-271
23. Seward JB, Khandheria BK, Freeman WK, et al. Multiplane transesophageal echocardiography: image orientation, examination technique, anatomic correlations, and clinical applications. Mayo Clin Proc. 1993 ; 68 (6). 523-551
24. Sadanandan S, Sherrid MV. Clinical and echocardiographic characteristics of left atrial spontaneous echo contrast in sinus rhythm. J Am Coll Cardiol. 2000 ; 35 (7). 1932-1938
25. Fatkin D, Kelly RP, Feneley MP. Relations between left atrial appendage blood flow velocity, spontaneous echocardiographic contrast and thromboembolic risk in vivo. J Am Coll Cardiol. 1994 ; 23 (4). 961-969
26. Pan M, Jiang MH, Wei MF, et al. Association of angiotensin-converting enzyme gene 2350G>A polymorphism with myocardial infarction in a Chinese population. Clin Appl Thromb Hemost. 2009 ; 15 (4). 435-442
27. Frustaci A, Chimenti C, Bellocci F, Morgante E, Russo MA, Maseri A. Histological substrate of atrial biopsies in patients with lone atrial fibrillation. Circulation. 1997 ; 96 (4). 1180-1184
28. Dernellis J, Panaretou M. C-reactive protein and paroxysmal atrial fibrillation: evidence of the implication of an inflammatory process in paroxysmal atrial fibrillation. Acta Cardiol. 2001 ; 56 (6). 375-380
29. Lip GY, Patel JV, Hughes E, Hart RG. High-sensitivity C-reactive protein and soluble CD40 ligand as indices of inflammation and platelet activation in 880 patients with nonvalvular atrial fibrillation: relationship to stroke risk factors, stroke risk stratification schema, and prognosis. Stroke. 2007 ; 38 (4). 1229-1237
30. Siu CW, Lau CP, Tse HF. Prevention of atrial fibrillation recurrence by statin therapy in patients with lone atrial fibrillation after successful cardioversion. Am J Cardiol. 2003 ; 92 (11). 1343-1345
31. Tetik S, Ak K, Sahin Y, et al. Postoperative statin therapy attenuates the intensity of systemic inflammation and increases fibrinolysis after coronary artery bypass grafting. Clin Appl Thromb Hemost. 2011 ; 17 (5). 526-531
32. Cermak J, Key NS, Bach RR, Balla J, Jacob HS, Vercellotti GM. C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor. Blood. 1993 ; 82 (2). 513-520
33. Burstein SA. Cytokines, platelet production and hemostasis. Platelets. 1997 ; 8 (2-3). 93-104
34. Herrera RN, de Amaya Ei D, Perez ARC, et al. Inflammatory and prothrombotic activation with conserved endothelial function in patients with chronic, asymptomatic Chagas disease. Clin Appl Thromb Hemost. 2011 ; 17 (5). 502-507
35. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue. Arterioscler Thromb Vasc Biol. 1999 ; 19 (4). 972-978
36. Watson T, Shantsila E, Lip GY. Mechanisms of thrombogenesis in atrial fibrillation: Virchow's triad revisited. Lancet. 2009 ; 373 (9658). 155-166
37. Thambidorai SK, Parakh K, Martin DO, et al. Relation of C-reactive protein correlates with risk of thromboembolism in patients with atrial fibrillation. Am J Cardiol. 2004 ; 94 (6). 805-807
38. Cianfrocca C, Loricchio ML, Pelliccia F, et al. C-reactive protein and left atrial appendage velocity are independent determinants of the risk of thrombogenesis in patients with atrial fibrillation. Int J Cardiol. 2010 ; 142 (1). 22-28
39. Baumann H, Gauldie J. Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation. Mol Biol Med. 1990 ; 7 (2). 147-159
40. Sakano N, Wang DH, Takahashi N, et al. Oxidative stress biomarkers and lifestyles in Japanese healthy people. J Clin Biochem Nutr. 2009 ; 44 (2). 185-195
41. Paik JK, Kim OY, Koh SJ, et al. Additive effect of interleukin-6 and C-reactive protein (CRP) single nucleotide polymorphism on serum CRP concentration and other cardiovascular risk factors. Clin Chim Acta. 2007 ; 380 (1-2). 68-74
42. Shin KK, Jang Y, Koh SJ, et al. Influence of the IL-6 -572C>G polymorphism on inflammatory markers according to cigarette smoking in Korean healthy men. Cytokine. 2007 ; 39 (2). 116-122
43. Kitamura A, Hasegawa G, Obayashi H, et al. Interleukin-6 polymorphism (-634C/G) in the promotor region and the progression of diabetic nephropathy in type 2 diabetes. Diabet Med. 2002 ; 19 (12). 1000-1005
44. Shibata N, Ohnuma T, Takahashi T, et al. Effect of IL-6 polymorphism on risk of Alzheimer disease: genotype-phenotype association study in Japanese cases. Am J Med Genet. 2002 ; 114 (4). 436-439
45. Jang Y, Kim OY, Hyun YJ, et al. Interleukin-6-572C>G polymorphism-association with inflammatory variables in Korean men with coronary artery disease. Transl Res. 2008 ; 151 (3). 154-161