IL-4 receptor blockade abrogates satellite cell: Rhabdomyosarcoma fusion and prevents tumor establishment

Stem Cells

Volumn 31, Issue 11, 2013, Pages 2304-2312

  Li, Guangheng ^a,b   Kikuchi, Ken ^b   Radka, Megan ^b   Abraham, Jinu ^b   Rubin, Brian P ^c   Keller, Charles ^b  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c TAUSSIG CANCER INSTITUTE   (United States)

Author keywords

Fusion; IL 4; Rhabdomyosarcoma; Satellite cells

Indexed keywords

BETA GALACTOSIDASE; CRE RECOMBINASE; INTERLEUKIN 4 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CELL FUSION; COCULTURE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; LOXP SITE; MALE; NONHUMAN; RECEPTOR BLOCKING; REPORTER GENE; RHABDOMYOSARCOMA; SARCOMA CELL; SKELETAL MUSCLE SATELLITE CELL;

MURINAE;

FUSION; IL-4; RHABDOMYOSARCOMA; SATELLITE CELLS;

ANIMALS; CELL DIFFERENTIATION; CELL FUSION; CELL LINE; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; MICE; RECEPTORS, INTERLEUKIN-4; RHABDOMYOSARCOMA, ALVEOLAR; SATELLITE CELLS, SKELETAL MUSCLE;

EID: 84887946611     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1491     Document Type: Article

References (24)

1. Skalli O, Gabbiani G, Babai F et al. Intermediate filament proteins and actin isoforms as markers for soft tissue tumor differentiation and origin. II. Rhabdomyosarcomas. Am J Pathol 1988; 130: 515-531. (Pubitemid 18091380)
2. Charytonowicz E, Cordon-Cardo C, Matushansky I et al. Alveolar rhabdomyosarcoma: Is the cell of origin a mesenchymal stem cell? Cancer Lett 2009; 279: 126-136.
3. Rubin BP, Nishijo K, Chen HI et al. Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma. Cancer Cell 2011; 19: 177-191.
4. Horsley V, Jansen KM, Mills ST et al. IL-4 acts as a myoblast recruitment factor during mammalian muscle growth. Cell 2003; 113: 483-494. (Pubitemid 36588751)
5. Duelli D, Lazebnik Y. Cell-to-cell fusion as a link between viruses and cancer. Nat Rev Cancer 2007; 7: 968-976. (Pubitemid 350165858)
6. Dittmar T, Nagler C, Schwitalla S et al. Recurrence cancer stem cells - Made by cell fusion? Med Hypotheses 2009; 73: 542-547.
7. Mi R, Pan C, Bian X et al. Fusion between tumor cells enhances melanoma metastatic potential. J Cancer Res Clin Oncol 2012; 138: 1651-1658.
8. Pawelek JM, Chakraborty AK. The cancer cell - Leukocyte fusion theory of metastasis. Adv Cancer Res 2008; 101: 397-444.
9. Nishijo K, Chen QR, Zhang L et al. Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma. Cancer Res 2009; 69: 2902-2911.
10. Keller C, Arenkiel BR, Coffin CM et al. Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: Cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev 2004; 18: 2614-2626. (Pubitemid 39453101)
11. Keller C, Hansen MS, Coffin CM et al. Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: Implications for alveolar rhabdo-myosarcoma cell of origin. Genes Dev 2004; 18: 2608-2613. (Pubitemid 39453100)
12. Hosoyama T, Aslam MI, Abraham J et al. IL-4R drives dedifferentiation, mitogenesis, and metastasis in rhabdomyosarcoma. Clin Cancer Res 2011; 17: 2757-2766.
13. Kikuchi K, Soundararajan A, Zarzabal LA et al. Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma. Oncogene 2013; 32: 286-295.
14. Nishijo K, Hosoyama T, Bjornson CR et al. Biomarker system for studying muscle, stem cells, and cancer in vivo. FASEB J 2009; 23: 2681-2690.
15. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 1999; 21: 70-71. (Pubitemid 29036285)
16. Allen RE, Temm-Grove CJ, Sheehan SM et al. Skeletal muscle satellite cell cultures. Methods Cell Biol 1997; 52: 155-176. (Pubitemid 128787393)
17. Li G, Peng H, Corsi K et al. Differential effect of BMP4 on NIH/3T3 and C2C12 cells: Implications for endochondral bone formation. J Bone Miner Res 2005; 20: 1611-1623. (Pubitemid 41243550)
18. Shea KL, Xiang W, La Porta VS et al. Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration. Cell Stem Cell 2010; 6: 117-129.
19. Prajapati SI, Martinez CO, Bahadur AN et al. Near-infrared imaging of injured tissue in living subjects using IR-820. Mol Imaging 2009; 8: 45-54.
20. Hettmer S, Liu J, Miller CM et al. Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells. Proc Natl Acad Sci USA 2011; 108: 20002-20007.
21. Parham DM, Qualman SJ, Teot L et al. Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: A report from the Children's Oncology Group. Am J Surg Pathol 2007; 31: 895-901. (Pubitemid 47165143)
22. Qualman SJ, Coffin CM, Newton WA et al. Intergroup Rhabdomyo-sarcoma study: Update for pathologists. Pediatr Dev Pathol 1998; 1: 550-561. (Pubitemid 128542175)
23. Weihua Z, Lin Q, Ramoth AJ et al. Formation of solid tumors by a single multinucleated cancer cell. Cancer 2011; 117: 4092-4099.
24. Corren J, Busse W, Meltzer EO et al. A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma. Am J Respir Crit Care Med 2010; 181: 788-796.