Regional Brain Glucose Uptake Distinguishes Suicide Attempters from Non-Attempters in Major Depression

Archives of Suicide Research

Volumn 17, Issue 4, 2013, Pages 434-447

  Sublette, M Elizabeth ^a,b   Milak, Matthew S ^a,b   Galfalvy, Hanga C ^a,b   Oquendo, Maria A ^a,b   Malone, Kevin M ^c   Mann, J John ^a,b  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

bipolar disorder; FDG; major depressive disorder; positron emission tomography; suicide

Indexed keywords

DIAGNOSTIC AGENT; FENFLURAMINE; FLUORODEOXYGLUCOSE F 18; GLUCOSE; RADIOPHARMACEUTICAL AGENT; SEROTONIN UPTAKE INHIBITOR;

ADULT; ARTICLE; BIPOLAR DISORDER; BRAIN; CASE CONTROL STUDY; CAUDATE NUCLEUS; CINGULATE GYRUS; CLINICAL TRIAL; DRUG EFFECT; FEMALE; HUMAN; MAJOR DEPRESSION; MALE; METABOLISM; MIDDLE AGED; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PUTAMEN; SCINTISCANNING; SINGLE BLIND PROCEDURE; SUICIDE ATTEMPT; YOUNG ADULT;

ADULT; BIPOLAR DISORDER; BRAIN; CASE-CONTROL STUDIES; CAUDATE NUCLEUS; DEPRESSIVE DISORDER, MAJOR; FEMALE; FENFLURAMINE; FLUORODEOXYGLUCOSE F18; GLUCOSE; GYRUS CINGULI; HUMANS; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PUTAMEN; RADIOPHARMACEUTICALS; SEROTONIN UPTAKE INHIBITORS; SINGLE-BLIND METHOD; SUICIDE, ATTEMPTED; YOUNG ADULT;

EID: 84887939022     PISSN: 13811118     EISSN: 15436136     Source Type: Journal    
DOI: 10.1080/13811118.2013.801813     Document Type: Article

References (54)

1. Anderson, A. D., Oquendo, M. A., Parsey, R. V., Campbell, C., & Mann, J. J. (2004). Regional brain responses to serotonin in major depressive disorder. Journal of Affective Disorders, 82 (3), 411 - 7.
2. Arango, V., Ernsberger, P., Marzuk, P. M., Chen, J. S., Tierney, H., Stanley, M., Mann, J. J. (1990). Autoradiographic demonstration of increased serotonin 5-HT2 and beta-adrenergic receptor binding sites in the brain of suicide victims. Archives of General Psychiatry, 47 (11), 1038 - 47.
3. Arango, V., Underwood, M. D., & Mann, J. J. (1997). Postmortem findings in suicide victims. Implications for in vivo imaging studies. Annals of the New York Academy of Sciences, 836, 269 - 87.
4. Asberg, M. (1997). Neurotransmitters and suicidal behavior. The evidence from cerebrospinal fluid studies. Annals of the New York Academy of Sciences, 836, 158 - 81.
5. Audenaert, K., Goethals, I., Van Laere, K., Lahorte, P., Brans, B., Verslipt, J., Kireckx, R. (2002). SPECT neuropsychological activation procedure with the Verbal Fluency Test in attempted suicide patients. Nuclear Medicine Communications, 23 (9), 907 - 16.
6. Baxter, L. R., Jr., Schwartz, J. M., Phelps, M. E., Mazziotta, J. C., Guze, B. H., Selin, C. E., Sumida, R. M. (1989). Reduction of prefrontal cortex glucose metabolism common to three types of depression. Archives of General Psychiatry, 46(3), 243-50.
7. Beck, A. T., Kovacs, M., & Weissman, A. (1979). Assessment of suicidal intention: The Scale for Suicide Ideation. Journal of Consulting and Clinical Psychology, 47 (2), 343 - 52.
8. Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561 - 71.
9. Biver, F., Goldman, S., Delvenne, V., Luxen, De Maertelaer, V., Hubain, P., Lotstra, F. (1994). Frontal and parietal metabolic disturbances in unipolar depression. Biological Psychiatry, 36 (6), 381 - 8.
10. Brett, M. (1999). The MNI brain and the Talairach atlas. MRC Cognition and Brain Sciences Unit.
11. Brody, A. L., Barsom, M. W., Bota, R. G., & Saxena, S. (2001a). Prefrontal-subcortical and limbic circuit mediation of major depressive disorder. Seminars in Clinical Neuropsychiatry, 6 (2), 102 - 12.
12. Brody, A. L., Saxena, S., Stoessel, P., Gillies, L. A., Fairbanks, L. A., Alborzian, S., Baxter, Jr., L. R. (2001b). Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: Preliminary findings. Archives of General Psychiatry, 58 (7), 631 - 40.
13. Cho, S. S., Ko, J. H., Pellecchia, G., Van Eimeren, T., Cilia, R., & Strafella, A. P. (2010). Continuous theta burst stimulation of right dorsolateral prefrontal cortex induces changes in impulsivity level. Brain Stimul, 3 (3), 170 - 6.
14. Coccaro, E. F., Lee, R., & Kavoussi, R. J. (2010). Aggression, suicidality, and intermittent explosive disorder: Serotonergic correlates in personality disorder and healthy control subjects. Neuropsychopharmacology, 35 (2), 435 - 44.
15. Correa, H., Duval, F., Mokrani, M., Bailey, P., Tremeau, F., Staner, L., Macher, J. P. (2000). Prolactin response to D-fenfluramine and suicidal behavior in depressed patients. Psychiatry Research, 93 (3), 189 - 99.
16. Drevets, W. C., Price, J. L., Bardgett, M. E., Reich, T., Todd, R. D., & Raichle, M. E. (2002). Glucose metabolism in the amygdala in depression: Relationship to diagnostic subtype and plasma cortisol levels. Pharmacology, Biochemistry and Behavior, 71 (3), 431 - 47.
17. Elliott, R., Baker, S. C., Rogers, R. D., O'Leary, D. A., Paykel, E. S., Frith, C. E., Sahakian, B. J. (1997). Prefrontal dysfunction in depressed patients performing a complex planning task: A study using positron emission tomography. Psychological Medicine, 27 (4), 931 - 42.
18. First, M., Williams, J., Spitzer, R., & Gibbon, M. (1997). Structured Clinical Interview for DSM-IV Axis I Disorders. Washington, D.C.: American Psychiatric.
19. Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. P., Frith, C. D., & Frackowiak, R. S. J. (1995). Statistical parametric maps in functional imaging: A general linear approach. Human Brain Mapping, 189 - 210.
20. Hamilton, J. P., Furman, D. J., Chang, C., Thomason, M. E., Dennis, E., & Gotlib, I. H. (2011). Default-mode and task-positive network activity in major depressive disorder: Implications for adaptive and maladaptive rumination. Biological Psychiatry, 70 (4), 327 - 33.
21. Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56 - 62.
22. Hurwitz, T. A., Clark, C., Murphy, E., Klonoff, H., Martin, W. R., & Pate, B. D. (1990). Regional cerebral glucose metabolism in major depressive disorder. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie, 35 (8), 684 - 8.
23. Jollant, F., Lawrence, N. S., Giampietro, V., Brammer, M. J., Fullana, M. A., Phillips, M. L. (2008). Orbitofrontal cortex response to angry faces in men with histories of suicide attempts. American Journal of Psychiatry, 165 (6), 740 - 8.
24. Keilp, J. G., Oquendo, M. A., Stanley, B. H., Burke, A. K., Cooper, T. B., Malone, K. M., & Mann, J. J. (2010). Future suicide attempt and responses to serotonergic challenge. Neuropsychopharmacology, 35 (5), 1063 - 72.
25. Kennedy, S. H., Evans, K. R., Kruger, S., Mayberg, H. S., Meyer, J. H., McCann, S., Vaccarino, F. J. (2001). Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression. American Journal of Psychiatry, 158 (6), 899 - 905.
26. Ketter, T. A., Kimbrell, T. A., George, M. S., Dunn, R. T., Speer, A. M., Benson, B. E., Post, R. M. (2001). Effects of mood and subtype on cerebral glucose metabolism in treatment-resistant bipolar disorder. Biological Psychiatry, 49 (2), 97 - 109.
27. Kimbrell, T. A., Ketter, T. A., George, M. S., Little, J. T., Benson, B. E., Willis, M. W., Post, R. M. (2002). Regional cerebral glucose utilization in patients with a range of severities of unipolar depression. Biological Psychiatry, 51 (3), 237 - 52.
28. Krebs, H. A., Cheng, L. K., & Wright, G. J. (1984). Determination of fenfluramine and norfenfluramine in plasma using a nitrogen-sensitive detector. Journal of Chromatography, 310(2), 412-7.
29. Lancaster, J. L., Woldorff, M. G., Parsons, L. M., Liotti, M., Freitas, C. S., Rainey, L., Fox, P. T. (2000). Automated Talairach atlas labels for functional brain mapping. Human Brain Mapping, 10 (3), 120 - 31.
30. Leyton, M., Paquette, V., Gravel, P., Rosa-Neto, P., Weston, F., Diksic, M., & Benkeflat, C. (2006). alpha-[11C]Methyl-L-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters. European Neuropsychopharmacology, 16 (3), 220 - 3.
31. Malone, K. M., Corbitt, E. M., Li, S., & Mann, J. J. (1996). Prolactin response to fenfluramine and suicide attempt lethality in major depression. British Journal of Psychiatry, 168 (3), 324 - 9.
32. Mann, J., Currier, D., Stanley, B., Oquendo, M. A., Ansell, L. V., & Ellis, S. P. (2006). Can biological tests assist prediction of suicide in mood disorders? International Journal of Neuropsychopharmacology, 9 (4), 465 - 74.
33. Mann, J. J., Ellis, S. P., Waternaux, C. M., Liu, X., Oquendo, M. A., Malone, K. M., Currier, D. (2008). Classification trees distinguish suicide attempters in major psychiatric disorders: A model of clinical decision making. Journal of Clinical Psychiatry, 69 (1), 23 - 31.
34. Mann, J. J., Malone, K. M., Diehl, D. J., Perel, J., Cooper, T. B., & Mintun, M. A. (1996a). Demonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients. American Journal of Psychiatry, 153 (2), 174 - 82.
35. Mann, J. J., Malone, K. M., Diehl, D. J., Perel, J., Nichols, T. E., & Mintun, M. A. (1996b). Positron emission tomographic imaging of serotonin activation effects on prefrontal cortex in healthy volunteers. Journal of Cerebral Blood Flow and Metabolism, 16 (3), 418 - 26.
36. Mann, J. J., Waternaux, C., Haas, G. L., & Malone, K. M. (1999). Toward a clinical model of suicidal behavior in psychiatric patients. American Journal of Psychiatry, 156 (2), 181 - 9.
37. Martinot, J. L., Hardy, P., Feline, A., Huret, J. D., Mazoyer, B., Attar-Levy, D., Syrota, A. (1990). Left prefrontal glucose hypometabolism in the depressed state: A confirmation. American Journal of Psychiatry, 147 (10), 1313 - 7.
38. Matthews, S., Spadoni, A., Knox, K., Strigo, I., & Simmons, A. (2012). Combat-exposed war veterans at risk for suicide show hyperactivation of prefrontal cortex and anterior cingulate during error processing. Psychosomatic Medicine, 74 (5), 471 - 5.
39. Milak, M. S., Keilp, J., Parsey, R. V., Oquendo, M. A., Malone, K. M., & Mann, J. J. (2010). Regional brain metabolic correlates of self-reported depression severity contrasted with clinician ratings. Journal of Affective Disorders, 126 (1-2), 113 - 24.
40. Milak, M. S., Parsey, R. V., Keilp, J., Oquendo, M. A., Malone, K. M., & Mann, J. J. (2005). Neuroanatomic correlates of psychopathologic components of major depressive disorder. Archives of General Psychiatry, 62 (4), 397 - 408.
41. Milak, M. S., Parsey, R. V., Lee, L., Oquendo, M. A., Olvet, D. M., Eipper, F., Mann, J. J. (2009). Pretreatment regional brain glucose uptake in the midbrain on PET may predict remission from a major depressive episode after three months of treatment. Psychiatry Research, 173 (1), 63 - 70.
42. Morrison, R., & O'Connor, R. C. (2008). A systematic review of the relationship between rumination and suicidality. Suicide and Life-Threatening Behavior, 38 (5), 523 - 38.
43. Myers, J. E., Mieczkowski, T., Perel, J., Abbondanza, D., Cooper, T. B., & Mann, J. J. (1994). Abnormal behavioral responses to fenfluramine in patients with affective and personality disorders. Correlation with increased serotonergic responsivity. Biological Psychiatry, 35 (2), 112 - 20.
44. Oquendo, M. A., Halberstam, B., & Mann, J. J. (2003). Risk factors for suicidal behavior: Utility and limitations of research instruments. In M. B. First (Ed.), Standardized Evaluation in Clinical Practice (pp. 103 - 30). Washington, D.C.: APPI Press.
45. Oquendo, M., Krunic, A., Parsey, R., Milak, M., Malone, K. M., Anderson, A., Mann, J. J. (2005a). Positron emission tomography of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without borderline personality disorder. Neuropsychopharmacology, 30 (6), 1163 - 72.
46. Oquendo, M. A., Krunic, A., Parsey, R. V., Milak, M., Malone, M. K., Anderson, A., Mann, J. J. (2005b). Positron emission tomography of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without borderline personality disorder. Neuropsychopharmacology, 30 (6), 1163 - 72.
47. Oquendo, M. A., Placidi, G. P., Malone, K. M., Campbell, C., Keilp, J., Brodsky, B., Mann, J. J. (2003). Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression. Archives of General Psychiatry, 60(1), 14-22.
48. Pan, L. A., Batezati-Alves, S. C., Almeida, J. R., Segreti, A., Akkal, D., Hassel, S., Phillips, M. L. (2011). Dissociable patterns of neural activity during response inhibition in depressed adolescents with and without suicidal behavior. Journal of the American Academy of Child and Adolescent Psychiatry, 50 (6), 602 - 11e3.
49. Perroud, N., Neidhart, E., Petit, B., Vessaz, M., Laforge, T., Relecom, C., Guipponi, M. (2010). Simultaneous analysis of serotonin transporter, tryptophan hydroxylase 1 and 2 gene expression in the ventral prefrontal cortex of suicide victims. American Journal of Medical Genetics Part B Neuropsychiatric Genetics, 153B (4), 909 - 18.
50. Reisch, T., Seifritz, E., Esposito, F., Wiest, R., Valach, L., & Michel, K. (2010). An fMRI study on mental pain and suicidal behavior. Journal of Affective Disorders, 126 (1-2), 321 - 5.
51. Schutter, D. J., & van Honk, J. (2009). The cerebellum in emotion regulation: A repetitive transcranial magnetic stimulation study. Cerebellum, 8 (1), 28 - 34.
52. Sublette, M. E., Milak, M. S., Hibbeln, J. R., Freed, P. J., Oquendo, M. A., Malone, K. M., Mann, J. J. (2009). Plasma polyunsaturated fatty acids and regional cerebral glucose metabolism in major depression. Prostaglandins Leukotrienes and Essential Fatty Acids, 80 (1), 57 - 64.
53. van Heeringen, C., Audenaert, K., Van Laere, K., Dumont, F., Slegers, G., Mertens, J., & Dierckx, R. A. (2003). Prefrontal 5-HT2a receptor binding index, hopelessness and personality characteristics in attempted suicide. Journal of Affective Disorders, 74 (2), 149 - 58.
54. Woods, R. P., Cherry, S. R., & Mazziotta, J. C. (1992). Rapid automated algorithm for aligning and reslicing PET images. Journal of Computer Assisted Tomography, 16 (4), 620 - 33.