Cas9-dependent endogenous gene regulation is required for bacterial virulence

Biochemical Society Transactions

Volumn 41, Issue 6, 2013, Pages 1407-1411

  Sampson, Timothy R ^a   Weiss, David S ^a,b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bacterial pathogenesis; Cas9; Clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated (Cas) system; Francisella; Innate immune evasion

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL RNA; BACTERIUM LIPOPOLYSACCHARIDE; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; FTN 0757 PROTEIN; MESSENGER RNA; REGULATOR PROTEIN; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG;

BACTERIAL GENE; BACTERIAL INFECTION; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONFERENCE PAPER; EPITHELIUM CELL; FRANCISELLA NOVICIDA; GENE CONTROL; GENE TARGETING; GENETIC PROCEDURES; GENETIC REGULATION; HOST; IMMUNE DEFICIENCY; IMMUNE EVASION; INFLAMMATION; INNATE IMMUNITY; MICROBIAL ACTIVITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION;

CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; FRANCISELLA; GENE EXPRESSION REGULATION, BACTERIAL; VIRULENCE;

EID: 84887931623     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20130163     Document Type: Conference Paper

References (20)

1. Wiedenheft, B., Sternberg, S.H. and Doudna, J.A. (2012) RNA-guided genetic silencing systems in bacteria and archaea. Nature 482, 331-338
2. Sampson, T.R., Saroj, S.D., Llewellyn, A.C., Tzeng, Y.L. and Weiss, D.S. (2013) A CRISPR/Cas system mediates bacterial innate immune evasion and virulence. Nature 497, 254-257
3. Weiss, D.S., Brotcke, A., Henry, T., Margolis, J.J., Chan, K. and Monack, D.M. (2007) In vivo negative selection screen identifies genes required for Francisella virulence. Proc. Natl. Acad. Sci. U.S.A. 104, 6037-6042
4. Jones, C.L., Napier, B.A., Sampson, T.R., Llewellyn, A.C., Schroeder, M.R. and Weiss, D.S. (2012) Subversion of host recognition and defense systems by Francisella spp. Microbiol. Mol. Biol. Rev. 76, 383-404
5. Sassetti, C.M., Boyd, D.H. and Rubin, E.J. (2001) Comprehensive identification of conditionally essential genes in mycobacteria. Proc. Natl. Acad. Sci. U.S.A. 98, 12712-12717
6. Salama, N.R., Shepherd, B. and Falkow, S. (2004) Global transposon mutagenesis and essential gene analysis of Helicobacter pylori. J. Bacteriol. 186, 7926-7935
7. Jones, C.L., Sampson, T.R., Nakaya, H.I., Pulendran, B. and Weiss, D.S. (2012) Repression of bacterial lipoprotein production by Francisella novicida facilitates evasion of innate immune recognition. Cell. Microbiol. 14, 1531-1543
8. Cole, L.E., Shirey, K.A., Barry, E., Santiago, A., Rallabhandi, P., Elkins, K.L., Puche, A.C., Michalek, S.M. and Vogel, S.N. (2007) Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophages. Infect. Immun. 75, 4127-4137
9. Katz, J., Zhang, P., Martin, M., Vogel, S.N. and Michalek, S.M. (2006) Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS. Infect. Immun. 74, 2809-2816
10. Li, H., Nookala, S., Bina, X.R., Bina, J.E. and Re, F. (2006) Innate immune response to Francisella tularensis is mediated by TLR2 and caspase-1 activation. J. Leukocyte Biol. 80, 766-773
11. Malik, M., Bakshi, C.S., Sahay, B., Shah, A., Lotz, S.A. and Sellati, T.J. (2006) Toll-like receptor 2 is required for control of pulmonary infection with Francisella tularensis. Infect. Immun. 74, 3657-3662
12. Aliprantis, A.O., Yang, R.B., Mark, M.R., Suggett, S., Devaux, B., Radolf, J.D., Klimpel, G.R., Godowski, P. and Zychlinsky, A. (1999) Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2. Science 285, 736-739
13. Brightbill, H.D., Libraty, D.H., Krutzik, S.R., Yang, R.B., Belisle, J.T., Bleharski, J.R., Maitland, M., Norgard, M.V., Plevy, S.E., Smale, S.T. et al. (1999) Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors. Science 285, 732-736
14. Makarova, K.S., Grishin, N.V., Shabalina, S.A., Wolf, Y.I. and Koonin, E.V. (2006) A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action. Biol. Direct 1, 7
15. Deltcheva, E., Chylinski, K., Sharma, C.M., Gonzales, K., Chao, Y., Pirzada, Z.A., Eckert, M.R., Vogel, J. and Charpentier, E. (2011) CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III. Nature 471, 602-607
16. Postic, G., Frapy, E., Dupuis, M., Dubail, I., Livny, J., Charbit, A. and Meibom, K.L. (2010) Identification of small RNAs in Francisella tularensis. BMC Genomics 11, 625
17. Chylinski, K., Le Rhun, A. and Charpentier, E. (2013) The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems. RNA Biol. 10, 726-737
18. Underhill, D.M., Ozinsky, A., Hajjar, A.M., Stevens, A., Wilson, C.B., Bassetti, M. and Aderem, A. (1999) The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401, 811-815
19. Makarova, K.S., Aravind, L., Wolf, Y.I. and Koonin, E.V. (2011) Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems. Biol. Direct 6, 38
20. Louwen, R., Horst-Kreft, D., de Boer, A.G., van der Graaf, L., de Knegt, G., Hamersma, M., Heikema, A.P., Timms, A.R., Jacobs, B.C., Wagenaar, J.A. et al. (2013) A novel link between Campylobacter jejuni bacteriophage defence, virulence and Guillain-Barreésyndrome. Eur. J. Clin. Microbiol. Infect. Dis. 32, 207-226