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Volumn 10, Issue 8, 2013, Pages 727-732

Synthesis and biological evaluations of 3-benzothiazol-2-yl coumarin derivatives as MEK1 inhibitors

Author keywords

Benzothiazolyl; Coumarin; Cyanation; Dock; MEK inhibitor; Unphosphorylated MEK1

Indexed keywords

COUMARIN DERIVATIVE; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 INHIBITOR; UNCLASSIFIED DRUG;

EID: 84887929957     PISSN: 15701808     EISSN: 1875628X     Source Type: Journal    
DOI: 10.2174/15701808113109990012     Document Type: Article
Times cited : (10)

References (28)
  • 1
    • 34547179997 scopus 로고    scopus 로고
    • MAP kinase pathways: The first twenty years
    • Avruch, J. MAP kinase pathways: The first twenty years. Biochim. Biophys. Acta, Mol. Cell Res., 2007, 1773 (8), 1150-1160.
    • (2007) Biochim. Biophys. Acta, Mol. Cell Res. , vol.1773 , Issue.8 , pp. 1150-1160
    • Avruch, J.1
  • 2
    • 0035212589 scopus 로고    scopus 로고
    • The ups and downs of MEK kinase interactions
    • Hagemann, C.; Blank, J. L. The ups and downs of MEK kinaseinteractions. Cell. Signal., 2001, 13 (12), 863-875.
    • (2001) Cell. Signal. , vol.13 , Issue.12 , pp. 863-875
    • Hagemann, C.1    Blank, J.L.2
  • 3
    • 34248591612 scopus 로고    scopus 로고
    • Targeting the Raf-MEK-ERK mitogenactivated protein kinase cascade for the treatment of cancer
    • Roberts, P. J.; Der, C. J. Targeting the Raf-MEK-ERK mitogenactivatedprotein kinase cascade for the treatment of cancer. Oncogene, 2007, 26 (22), 3291-310.
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3291-3310
    • Roberts, P.J.1    Der, C.J.2
  • 4
  • 7
    • 0041589377 scopus 로고    scopus 로고
    • High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines
    • Xu X.; Quiros, R. M.; Gattuso, P.; Ain, K. B.; Prinz, R. A. Highprevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines. Cancer Res., 2003, 63 (15), 4561-4567.
    • (2003) Cancer Res. , vol.63 , Issue.15 , pp. 4561-4567
    • Xu, X.1    Quiros, R.M.2    Gattuso, P.3    Ain, K.B.4    Prinz, R.A.5
  • 8
    • 33745063617 scopus 로고    scopus 로고
    • Recent progress in development of non-ATP competitive smallmolecule inhibitors of protein kinases
    • Kiselyov, A.; Balakin, K. V.; Tkachenko, S. E.; Savchuk, N. P. Recent progress in development of non-ATP competitive smallmoleculeinhibitors of protein kinases. Mini-Rev. Med. Chem., 2006, 6(6), 711-717.
    • (2006) Mini-Rev. Med. Chem. , vol.6 , Issue.6 , pp. 711-717
    • Kiselyov, A.1    Balakin, K.V.2    Tkachenko, S.E.3    Savchuk, N.P.4
  • 10
    • 84855894652 scopus 로고    scopus 로고
    • Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy
    • Santarpia, L.; Lippman, S. M.; El-Naggar, A. K. Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy. Expert Opin. Ther. Targets, 2012, 16 (1), 103-119.
    • (2012) Expert Opin. Ther. Targets , vol.16 , Issue.1 , pp. 103-119
    • Santarpia, L.1    Lippman, S.M.2    El-Naggar, A.K.3
  • 11
    • 84858227014 scopus 로고    scopus 로고
    • RAS/RAF/MEK inhibitors in oncology
    • Rusconi, P.; Caiola, E.; Broggini, M. RAS/RAF/MEK inhibitors inoncology. Curr. Med. Chem., 2012, 19(8), 1164-1176.
    • (2012) Curr. Med. Chem. , vol.19 , Issue.8 , pp. 1164-1176
    • Rusconi, P.1    Caiola, E.2    Broggini, M.3
  • 12
    • 46849116601 scopus 로고    scopus 로고
    • Putative allosteric MEK1 and MEK2 inhibitors
    • Price, S. Putative allosteric MEK1 and MEK2 inhibitors. ExpertOpin. Ther. Pat., 2008, 18(6), 603-627.
    • (2008) ExpertOpin. Ther. Pat. , vol.18 , Issue.6 , pp. 603-627
    • Price, S.1
  • 14
    • 79959444801 scopus 로고    scopus 로고
    • MEK inhibitors: A patent review 2008 -2010
    • Trujillo, J. I. MEK inhibitors: a patent review 2008 -2010. ExpertOpin. Ther. Pat., 2011, 21(7), 1045-1069.
    • (2011) Expert Opin. Ther. Pat. , vol.21 , Issue.7 , pp. 1045-1069
    • Trujillo, J.I.1
  • 20
    • 78649790745 scopus 로고    scopus 로고
    • The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of RO5068760, an MEK inhibitor, in healthy volunteers: Assessment of target suppression
    • Lee, L.; Niu, H.; Goelzer, P.; Rueger, R.; Deutsch, J.; Busse-Reid, R.; DeSchepper, S.; Blotner, S.; Barrett, J.; Weissgerber, G.; Peck, R. The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of RO5068760, an MEK inhibitor, inhealthy volunteers: assessment of target suppression. J. Clin. Pharmacol., 2010, 50(12), 1397-1405.
    • (2010) J. Clin. Pharmacol. , vol.50 , Issue.12 , pp. 1397-1405
    • Lee, L.1    Niu, H.2    Goelzer, P.3    Rueger, R.4    Deutsch, J.5    Busse-Reid, R.6    Deschepper, S.7    Blotner, S.8    Barrett, J.9    Weissgerber, G.10    Peck, R.11
  • 22
    • 11444268281 scopus 로고    scopus 로고
    • Synthetic and natural coumarins as cytotoxic agents
    • Kostova, I. Synthetic and natural coumarins as cytotoxic agents. Anti-Cancer Agents Med. Chem., 2005, 5(1), 29-46.
    • (2005) Anti-Cancer Agents Med. Chem. , vol.5 , Issue.1 , pp. 29-46
    • Kostova, I.1
  • 23
    • 84866863717 scopus 로고    scopus 로고
    • 7-Alkyl-3-benzylcoumarins: A versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists
    • Rempel, V.; Volz, N.; Hinz, S.; Karcz, T.; Meliciani, I.; Nieger, M.; Wenzel, W.; Brase, S.; Muller, C. E. 7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists. J. Med. Chem., 2012, 55(18), 7967-7977.
    • (2012) J. Med. Chem. , vol.55 , Issue.18 , pp. 7967-7977
    • Rempel, V.1    Volz, N.2    Hinz, S.3    Karcz, T.4    Meliciani, I.5    Nieger, M.6    Wenzel, W.7    Brase, S.8    Muller, C.E.9
  • 24
    • 0032767738 scopus 로고    scopus 로고
    • Coumarin metabolism, toxicity and carcinogenicity: Relevance for human risk assessment
    • Lake, B. G. Coumarin Metabolism, Toxicity and Carcinogenicity:Relevance for Human Risk Assessment. Food Chem. Toxicol., 1999, 37 (4), 423-453.
    • (1999) Food Chem. Toxicol. , vol.37 , Issue.4 , pp. 423-453
    • Lake, B.G.1
  • 25
    • 20044366228 scopus 로고    scopus 로고
    • LC Determination of coumarin-3-acyl derivatives for evaluation of the stability and monoamine oxidase inhibition mechanism
    • Chimenti, F.; Secci, D.; Bolasco, A.; Chimenti, P.; Granese, A.; Gagliardi, L.; De Orsi, D. LC Determination of coumarin-3-acylderivatives for evaluation of the stability and monoamine oxidaseinhibition mechanism. Chromatographia, 2005, 61 (9-10), 519-522.
    • (2005) Chromatographia , vol.61 , Issue.9-10 , pp. 519-522
    • Chimenti, F.1    Secci, D.2    Bolasco, A.3    Chimenti, P.4    Granese, A.5    Gagliardi, L.6    De Orsi, D.7
  • 26
    • 84878272373 scopus 로고    scopus 로고
    • Substituted 3-benzyl coumarins as allosteric mek1 inhibitors: Design, synthesis and biological evaluations as antiviral agents
    • (accepted)
    • Wang C.; Zhang H.; Xu F.; Niu Y.; Wu Y.; Wang X.; Peng Y.; SunJ.; Liang L.; Xu P. Substituted 3-Benzyl Coumarins as AllostericMEK1 Inhibitors: Design, Synthesis and Biological Evaluations asAntiviral Agents. Molecules, 2013, 18, 1-x(accepted).
    • (2013) Molecules , vol.18
    • Wang, C.1    Zhang, H.2    Xu, F.3    Niu, Y.4    Wu, Y.5    Wang, X.6    Peng, Y.7    Sun, J.8    Liang, L.9    Xu, P.10
  • 27
    • 84871107842 scopus 로고    scopus 로고
    • Comparison of the efficiencies of two trfret methods to detect in vitro natural and synthesized inhibitors of the raf/mek/erk signaling pathway
    • S.R. Fabienne Saab, Jean-Yves Mérour, Valérie Bénéteau, Françoise Schoentgen. Comparison of the efficiencies of two TRFRETmethods to detect in vitro natural and synthesized inhibitors of the Raf/MEK/ERK signaling pathway. International Journal of High Throughput Screening, 2010, 1, 81-98.
    • (2010) International Journal of High Throughput Screening , vol.1 , pp. 81-98
    • Fabienne Saab, S.R.1    Mérour, J.-Y.2    Bénéteau, V.3    Schoentgen, F.4
  • 28
    • 84887896712 scopus 로고    scopus 로고
    • (Accessed May 17)
    • http://www.ccdc.cam.ac.uk/products/life-sciences/gold/. (AccessedMay 17, 2013).
    • (2013)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.