Alu elements: At the crossroads between disease and evolution

Biochemical Society Transactions

Volumn 41, Issue 6, 2013, Pages 1532-1535

  Ule, Jernej ^a,b  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Alternative splicing; Alu element; Disease; Evolution; Intron; Transposable element

Indexed keywords

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN C; MESSENGER RNA; MICRORNA; RNA ISOFORM; SMALL NUCLEOLAR RNA; UNTRANSLATED RNA;

ALTERNATIVE RNA SPLICING; ALU SEQUENCE; CONFERENCE PAPER; DNA SEQUENCE; ENHANCER REGION; EXON; GENE FUNCTION; GENETIC VARIABILITY; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN GENOME; INTRON; PERSONALIZED MEDICINE; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN RNA BINDING; RNA EDITING; RNA PROCESSING; TRANSPOSON; UNTRANSLATED REGION;

ALU ELEMENTS; DISEASE; EVOLUTION, MOLECULAR; EXONS; HUMANS;

EID: 84887902305     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20130157     Document Type: Conference Paper

References (13)

1. Wang, Y., Xiao, X., Zhang, J., Choudhury, R., Robertson, A., Li, K., Ma, M., Burge, C.B. and Wang, Z. (2013) A complex network of factors with overlapping affinities represses splicing through intronic elements. Nat. Struct. Mol. Biol. 20, 36-45
2. Keren, H., Lev-Maor, G. and Ast, G. (2010) Alternative splicing and evolution: diversification, exon definition and function. Nat. Rev. Genet. 11, 345-355
3. Cowley, M. and Oakey, R.J. (2013) Transposable elements re-wire and fine-tune the transcriptome. PLoS Genet. 9, e1003234
4. Jacques, P.E., Jeyakani, J. and Bourque, G. (2013) The majority of primate-specific regulatory sequences are derived from transposable elements. PLoS Genet. 9, e1003504
5. Kriegs, J.O., Churakov, G., Jurka, J., Brosius, J. and Schmitz, J. (2007) Evolutionary history of 7SL RNA-derived SINEs in supraprimates. Trends Genet. 23, 158-161
6. Sela, N., Mersch, B., Gal-Mark, N., Lev-Maor, G., Hotz-Wagenblatt, A. and Ast, G. (2007) Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome. Genome Biol. 8, R127
7. Lin, L., Shen, S., Tye, A., Cai, J.J., Jiang, P., Davidson, B.L. and Xing, Y. (2008) Diverse splicing patterns of exonized Alu elements in human tissues. PLoS Genet. 4, e1000225
8. Zarnack, K., Konig, J., Tajnik, M., Martincorena, I., Eustermann, S., Stevant, I., Reyes, A., Anders, S., Luscombe, N.M. and Ule, J. (2013) Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements. Cell 152, 453-466
9. Konig, J., Zarnack, K., Luscombe, N.M. and Ule, J. (2012) Protein-RNA interactions: new genomic technologies and perspectives. Nat. Rev. Genet. 13, 77-83
10. Vorechovsky, I. (2010) Transposable elements in disease-associated cryptic exons. Hum. Genet. 127, 135-154
11. Kluge, C., Brecevic, L., Heizmann, C.W., Blau, N. and Thony, B. (1996) Chromosomal localization, genomic structure and characterization of the human gene and a retropseudogene for 6-pyruvoyltetrahydropterin synthase. Eur. J. Biochem. 240, 477-484
12. Gogvadze, E. and Buzdin, A. (2009) Retroelements and their impact on genome evolution and functioning. Cell. Mol. Life Sci. 66, 3727-3742
13. Harrison, R.J. (2012) Understanding genetic variation and function: the applications of next generation sequencing. Semin. Cell Dev. Biol. 23, 230-236