High incidence of Aggregatibacter actinomycetemcomitans infection in patients with cerebral infarction and diabetic renal failure: A cross-sectional study

BMC Infectious Diseases

Volumn 13, Issue 1, 2013, Pages

  Murakami, Minoru ^a   Suzuki, Jun ichi ^b   Yamazaki, Satoshi ^a   Ikezoe, Masaya ^a   Matsushima, Rintaro ^a   Ashigaki, Norihiko ^c   Aoyama, Norio ^c   Kobayashi, Naho ^c   Wakayama, Kouji ^b   Akazawa, Hiroshi ^b   Komuro, Issei ^b   Izumi, Yuichi ^c   Isobe, Mitsuaki ^c  

^a Saku Central Hospital Advanced Care Center   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Aggregatibacter actinomycetemcomitans; Cerebral infarction; Diabetic nephropathy; Periodontitis

Indexed keywords

ANTICOAGULANT AGENT; ANTIHYPERTENSIVE AGENT; ANTITHROMBOCYTIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ADULT; AGED; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; AGGREGATIBACTER ACTINOMYCETEMCOMITANS INFECTION; ARTICLE; BLOOD EXAMINATION; BLOOD SAMPLING; BRAIN INFARCTION; CHRONIC PERIODONTITIS; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; FEMALE; HEMODIALYSIS; HUMAN; HUMAN CELL; HYPERTENSION; IMMUNE RESPONSE; INCIDENCE; KIDNEY FAILURE; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PASTEURELLACEAE INFECTION; PERIODONTAL EXAMINATION; PORPHYROMONAS GINGIVALIS; PREVOTELLA INTERMEDIA; SALIVA ANALYSIS; SCORING SYSTEM; TOOTH PLAQUE; TOOTH RADIOGRAPHY;

AGED; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; CEREBRAL INFARCTION; CROSS-SECTIONAL STUDIES; DIABETIC NEPHROPATHIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PASTEURELLA INFECTIONS; PERIODONTITIS; RENAL INSUFFICIENCY;

EID: 84887895884     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-13-557     Document Type: Article

References (46)

1. Hostetter TH. Chronic kidney disease predicts cardiovascular disease. N Engl J Med 2004, 351:1344-1346.
2. Cozzolino M, Biondi ML, Galassi A, Cusi D, Brancaccio D, Gallieni M. Vascular calcification and cardiovascular outcome in dialysis patients: the role of gene polymorphisms. Blood Purif 2010, 29:347-351. 10.1159/000302722, 20357434.
3. Kshirsagar AV, Moss KL, Elter JR, Beck JD, Offenbacher S, Falk RJ. Periodontal disease is associated with renal insufficiency in the Atherosclerosis Risk In Communities (ARIC) study. Am J Kidney Dis 2005, 45:650-657. 10.1053/j.ajkd.2004.12.009, 15806467.
4. Fisher MA, Taylor GW, Shelton BJ, Jamerson KA, Rahman M, Ojo AO, Sehgal AR. Periodontal disease and other nontraditional risk factors for CKD. Am J Kidney Dis 2008, 51:45-52. 10.1053/j.ajkd.2007.09.018, 18155532.
5. Moutsopoulos NM, Madianos PN. Low-grade inflammation in chronic infectious diseases: paradigm of periodontal infections. Ann N Y Acad Sci 2006, 1088:251-264. 10.1196/annals.1366.032, 17192571.
6. Kalantar-Zadeh K, Block G, Humphreys MH, Kopple JD. Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int 2003, 63:793-808. 10.1046/j.1523-1755.2003.00803.x, 12631061.
7. Stenvinkel P. Inflammation in end-stage renal disease: the hidden enemy. Nephrology 2006, 11:36-41. 10.1111/j.1440-1797.2006.00541.x, 16509930.
8. Grau AJ, Becher H, Ziegler CM, Lichy C, Buggle F, Kaiser C, Lutz R, Bultmann S, Preusch M, Dorfer CE. Periodontal disease as a risk factor for ischemic stroke. Stroke 2004, 35:496-501. 10.1161/01.STR.0000110789.20526.9D, 14707235.
9. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 2004, 351:1296-1305. 10.1056/NEJMoa041031, 15385656.
10. Kobayashi M, Hirawa N, Yatsu K, Kobayashi Y, Yamamoto Y, Saka S, Andoh D, Toya Y, Yasuda G, Umemura S. Relationship between silent brain infarction and chronic kidney disease. Nephrol Dial Transplant 2009, 24:201-207. 2639313, 18697797.
11. Daugirdas JT. The post: pre-dialysis plasma urea nitrogen ratio to estimate K.t/V and NPCR: mathematical modeling. Int J Artif Organs 1989, 12:411-419.
12. Jervoe-Storm PM, AlAhdab H, Koltzscher M, Fimmers R, Jepsen S. Quantification of periodontal pathogens by paper point sampling from the coronal and apical aspect of periodontal lesions by real-time PCR. Clinical oral investigations 2010, 14:533-541. 10.1007/s00784-009-0333-x, 19693550.
13. Maeda H, Fujimoto C, Haruki Y, Maeda T, Kokeguchi S, Petelin M, Arai H, Tanimoto I, Nishimura F, Takashiba S. Quantitative real-time PCR using TaqMan and SYBR Green for Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, tetQ gene and total bacteria. FEMS immunol Med Microbiol 2003, 39:81-86. 10.1016/S0928-8244(03)00224-4, 14557000.
14. Sakamoto M, Takeuchi Y, Umeda M, Ishikawa I, Benno Y. Rapid detection and quantification of five periodontopathic bacteria by real-time PCR. Microbiol Immunol 2001, 45:39-44. 10.1111/j.1348-0421.2001.tb01272.x, 11270605.
15. Wang D, Kawashima Y, Nagasawa T, Takeuchi Y, Kojima T, Umeda M, Oda S, Ishikawa I. Elevated serum IgG titer and avidity to Actinobacillus actinomycetemcomitans serotype c in Japanese periodontitis patients. Oral Microbiol Immunol 2005, 20:172-179. 10.1111/j.1399-302X.2005.00208.x, 15836519.
16. Zhu YC, Dufouil C, Tzourio C, Chabriat H. Silent brain infarcts: a review of MRI diagnostic criteria. Stroke 2011, 42:1140-1145. 10.1161/STROKEAHA.110.600114, 21393597.
17. Kshirsagar AV, Craig RG, Moss KL, Beck JD, Offenbacher S, Kotanko P, Klemmer PJ, Yoshino M, Levin NW, Yip JK, Almas K, Lupovici EM, Usvyat LA, Falk RJ. Periodontal disease adversely affects the survival of patients with end-stage renal disease. Kidney Int 2009, 75:746-751. 10.1038/ki.2008.660, 19165177.
18. Scannapieco FA, Bush RB, Paju S. Associations between periodontal disease and risk for atherosclerosis, cardiovascular disease, and stroke. A systematic review. Ann Periodontol 2003, 8:38-53. 10.1902/annals.2003.8.1.38, 14971247.
19. Roivainen M, Viik-Kajander M, Palosuo T, Toivanen P, Leinonen M, Saikku P, Tenkanen L, Manninen V, Hovi T, Manttari M. Infections, inflammation, and the risk of coronary heart disease. Circulation 2000, 101:252-257. 10.1161/01.CIR.101.3.252, 10645920.
20. Takeuchi Y, Ishikawa H, Inada M, Shinozuka O, Umeda M, Yamazaki T, Yoshikawa M, Sasaki S. Study of the oral microbial flora in patients with renal disease. Nephrology 2007, 12:182-190. 10.1111/j.1440-1797.2007.00767.x, 17371344.
21. Bastos JA, Diniz CG, Bastos MG, Vilela EM, Silva VL, Chaoubah A, Souza-Costa DC, Andrade LC. Identification of periodontal pathogens and severity of periodontitis in patients with and without chronic kidney disease. Arch Oral Biol 2011, 56:804-811. 10.1016/j.archoralbio.2010.12.006, 21211789.
22. Wara-aswapati N, Pitiphat W, Chanchaimongkon L, Taweechaisupapong S, Boch JA, Ishikawa I. Red bacterial complex is associated with the severity of chronic periodontitis in a Thai population. Oral Dis 2009, 15:354-359. 10.1111/j.1601-0825.2009.01562.x, 19371397.
23. Ohlrich EJ, Cullinan MP, Leichter JW. Diabetes, periodontitis, and the subgingival microbiota. J Oral Microbiol 2010, 2: .
24. Jansson H, Lindholm E, Lindh C, Groop L, Bratthall G. Type 2 diabetes and risk for periodontal disease: a role for dental health awareness. J Clin Periodontol 2006, 33:408-414. 10.1111/j.1600-051X.2006.00929.x, 16677329.
25. Shultis WA, Weil EJ, Looker HC, Curtis JM, Shlossman M, Genco RJ, Knowler WC, Nelson RG. Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes. Diabetes Care 2007, 30:306-311. 10.2337/dc06-1184, 17259499.
26. Darre L, Vergnes JN, Gourdy P, Sixou M. Efficacy of periodontal treatment on glycaemic control in diabetic patients: a meta-analysis of interventional studies. Diabetes Metab 2008, 34:497-506. 10.1016/j.diabet.2008.03.006, 18948050.
27. Ghizoni JS, Taveira LA, Garlet GP, Ghizoni MF, Pereira JR, Dionisio TJ, Brozoski DT, Santos CF, Sant'Ana AC. Increased levels of Porphyromonas gingivalis are associated with ischemic and hemorrhagic cerebrovascular disease in humans: an in vivo study. J Appl Oral Sci 2012, 20:104-112. 10.1590/S1678-77572012000100019, 22437687.
28. Zambon JJ. Actinobacillus actinomycetemcomitans in human periodontal disease. J Clin Periodontol 1985, 12:1-20. 10.1111/j.1600-051X.1985.tb01348.x, 3882766.
29. He J, Huang W, Pan Z, Cui H, Qi G, Zhou X, Chen H. Quantitative analysis of microbiota in saliva, supragingival, and subgingival plaque of Chinese adults with chronic periodontitis. Clin oral investig 2012, 16:1579-1588. 10.1007/s00784-011-0654-4, 22169888.
30. Papapanou PN, Baelum V, Luan WM, Madianos PN, Chen X, Fejerskov O, Dahlen G. Subgingival microbiota in adult Chinese: prevalence and relation to periodontal disease progression. J Periodontol 1997, 68:651-666. 10.1902/jop.1997.68.7.651, 9249637.
31. Papapanou PN, Teanpaisan R, Obiechina NS, Pithpornchaiyakul W, Pongpaisal S, Pisuithanakan S, Baelum V, Fejerskov O, Dahlen G. Periodontal microbiota and clinical periodontal status in a rural sample in southern Thailand. Eur J Oral Sci 2002, 110:345-352. 10.1034/j.1600-0722.2002.21361.x, 12664464.
32. Choi BK, Park SH, Yoo YJ, Choi SH, Chai JK, Cho KS, Kim CK. Detection of major putative periodontopathogens in Korean advanced adult periodontitis patients using a nucleic acid-based approach. J Periodontol 2000, 71:1387-1394. 10.1902/jop.2000.71.9.1387, 11022767.
33. Takeuchi Y, Umeda M, Ishizuka M, Huang Y, Ishikawa I. Prevalence of periodontopathic bacteria in aggressive periodontitis patients in a Japanese population. J Periodontol 2003, 74:1460-1469. 10.1902/jop.2003.74.10.1460, 14653392.
34. Brouqui P, Raoult D. Endocarditis due to rare and fastidious bacteria. Clin Microbiol Rev 2001, 14:177-207. 10.1128/CMR.14.1.177-207.2001, 88969, 11148009.
35. Horowitz EA, Pugsley MP, Turbes PG, Clark RB. Pericarditis caused by Actinobacillus actinomycetemcomitans. J Infect Dis 1987, 155:152-153. 10.1093/infdis/155.1.152, 3794401.
36. Kozarov E, Sweier D, Shelburne C, Progulske-Fox A, Lopatin D. Detection of bacterial DNA in atheromatous plaques by quantitative PCR. Microbes Infect 2006, 8:687-693. 10.1016/j.micinf.2005.09.004, 16513386.
37. Pussinen PJ, Alfthan G, Rissanen H, Reunanen A, Asikainen S, Knekt P. Antibodies to periodontal pathogens and stroke risk. Stroke 2004, 35:2020-2023. 10.1161/01.STR.0000136148.29490.fe, 15232116.
38. Pussinen PJ, Nyyssonen K, Alfthan G, Salonen R, Laukkanen JA, Salonen JT. Serum antibody levels to Actinobacillus actinomycetemcomitans predict the risk for coronary heart disease. Arterioscler Thromb Vasc Biol 2005, 25:833-838. 10.1161/01.ATV.0000157982.69663.59, 15692101.
39. Henderson B, Nair SP, Ward JM, Wilson M. Molecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans. Annu Rev Microbiol 2003, 57:29-55. 10.1146/annurev.micro.57.030502.090908, 14527274.
40. Meyer DH, Lippmann JE, Fives-Taylor PM. Invasion of epithelial cells by Actinobacillus actinomycetemcomitans: a dynamic, multistep process. Infect Immun 1996, 64:2988-2997. 174179, 8757825.
41. Sandberg WJ, Yndestad A, Oie E, Smith C, Ueland T, Ovchinnikova O, Robertson AK, Muller F, Semb AG, Scholz H, Andreassen AK, Gullestad L, Damås JK, Frøland SS, Hansson GK, Halvorsen B, Aukrust P. Enhanced T-cell expression of RANK ligand in acute coronary syndrome: possible role in plaque destabilization. Arterioscler Thromb Vasc Biol 2006, 26:857-863. 10.1161/01.ATV.0000204334.48195.6a, 16424351.
42. Higo S, Uematsu M, Yamagishi M, Ishibashi-Ueda H, Awata M, Morozumi T, Ohara T, Nanto S, Nagata S. Elevation of plasma matrix metalloproteinase-9 in the culprit coronary artery in patients with acute myocardial infarction: clinical evidence from distal protection. Circ J 2005, 69:1180-1185. 10.1253/circj.69.1180, 16195613.
43. Hosomi N, Aoki S, Matsuo K, Deguchi K, Masugata H, Murao K, Ichihara N, Ohyama H, Dobashi H, Nezu T, Ohtsuki T, Yasuda O, Soejima H, Ogawa H, Izumi Y, Kohno M, Tanaka J, Matsumoto M. Association of serum anti-periodontal pathogen antibody with ischemic stroke. Cerebrovasc Dis 2012, 34:385-392. 10.1159/000343659, 23207319.
44. Lally ET, Hill RB, Kieba IR, Korostoff J. The interaction between RTX toxins and target cells. Trends Microbiol 1999, 7:356-361. 10.1016/S0966-842X(99)01530-9, 10470043.
45. Fine DH, Kaplan JB, Kachlany SC, Schreiner HC. How we got attached to Actinobacillus actinomycetemcomitans: a model for infectious diseases. Periodontol 2000 2006, 42:114-157. 10.1111/j.1600-0757.2006.00189.x, 16930309.
46. Kaplan JB, Schreiner HC, Furgang D, Fine DH. Population structure and genetic diversity of Actinobacillus actinomycetemcomitans strains isolated from localized juvenile periodontitis patients. J Clin Microbiol 2002, 40:1181-1187. 10.1128/JCM.40.4.1181-1187.2002, 140340, 11923328.