A Systematic Review of Multivitamin-Multimineral Use and Cardiovascular Disease and Cancer Incidence and Total Mortality

Journal of the American College of Nutrition

Volumn 32, Issue 5, 2013, Pages 339-354

  Alexander, Dominik D ^a   Weed, Douglas L ^b   Chang, Ellen T ^a   Miller, Paige E ^a   Mohamed, Muhima A ^a   Elkayam, Laura ^a  

^a EXPONENT INC   (United States)

^b DLW Consulting Services LLC   (United States)

Author keywords

cancer; cardiovascular disease; minerals; mortality; supplements; vitamins

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; MINERAL; MULTIVITAMIN; PLACEBO; SELENIUM; ZINC;

ARTICLE; CANCER INCIDENCE; CANCER RISK; CARDIOVASCULAR DISEASE; CEREBROVASCULAR DISEASE; DISEASE ASSOCIATION; FOLLOW UP; HEART INFARCTION; HUMAN; ISCHEMIC HEART DISEASE; LIFESTYLE; MORTALITY; RANDOMIZED CONTROLLED TRIAL (TOPIC); SINGLE DRUG DOSE; SYSTEMATIC REVIEW;

CARDIOVASCULAR DISEASES; CAUSE OF DEATH; DIETARY SUPPLEMENTS; EUROPE; HUMANS; JAPAN; MINERALS; NEOPLASMS; TRACE ELEMENTS; UNITED STATES; VITAMINS;

EID: 84887883834     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2013.839909     Document Type: Article

References (56)

1. Marra, M V and Boyar, A P. 2009. Position of the American Dietetic Association: nutrient Supplementation. J Am Diet Assoc, 109: 2073 - 2085.
2. US Department of Health and Human Services and US Department of Agriculture. 2011. " Dietary Guidelines for Americans, 2010 ". In, 7th ed., Washington, DC: US Government Printing Office.
3. Fulgoni, V L III, Keast, D R, Bailey, R L and Dwyer, J. 2011. Foods, fortificants, and Supplements: where do Americans get their nutrients?. J Nutr, 141: 1847 - 1854.
4. 2006. NIH State-of-the-Science Conference Statement on Multivitamin/Mineral Supplements and Chronic Disease Prevention. NIH Consens State Sci Statements, 23: 1 - 30.
5. Huang, H Y, Caballero, B, Chang, S, Alberg, A J, Semba, R D, Schneyer, C R, Wilson, R F, Cheng, T Y, Vassy, J, Prokopowicz, G, Barnes, GJ and Bass, EB. 2006. The efficacy and safety of multivitamin and mineral SUPPL.ement use to prevent cancer and chronic disease in adults: a systematic review for a National Institutes of Health State-of-the-Science Conference. Ann Intern Med, 145: 372 - 385.
6. Bailey, R L, Gahche, J J, Lentino, C V, Dwyer, J T, Engel, J S, Thomas, P R, Betz, J M, Sempos, C T and Picciano, M F. 2011. Dietary SUPPL.ement use in the United States, 2003-2006. J Nutr, 141: 261 - 266. 2nd
7. Gahche, J, Bailey, R, Burt, V, Hughes, J, Yetley, E, Dwyer, J, Picciano, M F, McDowell, M and Sempos, C. 2011. Dietary SUPPL.ement use among US adults has increased since NHANES III (1988-1994). NCHS Data Brief, 61: 1 - 8.
8. Greenwald, P, Anderson, D, Nelson, S A and Taylor, P R. 2007. Clinical trials of vitamin and mineral Supplements for cancer prevention. Am J Clin Nutr, 85: 314S - 317S.
9. Dickinson, A, Bonci, L, Boyon, N and Franco, J C. 2012. Dietitians use and recommend dietary Supplements: report of a survey. Nutr J, 11: 14
10. Schutz, H G, Read, M, Bendel, R, Bhalla, V S, Harrill, I, Monagle, J E, Sheehan, E T and Standal, B R. 1982. Food SUPPL.ement usage in seven Western states. Am J Clin Nutr, 36: 897 - 901.
11. Neuhouser, M L, Wassertheil-Smoller, S, Thomson, C, Aragaki, A, Anderson, G L, Manson, J E, Patterson, R E, Rohan, T E, van Horn, L, Shikany, J M, Thomas, A, LaCroix, A and Prentice, RL. 2009. Multivitamin use and risk of cancer and cardiovascular disease in the Women's Health Initiative cohorts. Arch Intern Med, 169: 294 - 304.
12. Sesso, H D, Christen, W G, Bubes, V, Smith, J P, MacFadyen, J, Schvartz, M, Manson, J E, Glynn, R J, Buring, J E and Gaziano, J M. 2012. Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA, 308: 1751 - 1760.
13. Gaziano, D, Sesso, H D, Christen, W G, Bubes, V, Smith, J P, MacFadyen, J, Schvartz, M, Manson, J E, Glynn, R J and Buring, J E. 2012. Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA, 308: 1871 - 1880.
14. Li, K, Kaaks, R, Linseisen, J and Rohrmann, S. 2012. Vitamin/mineral SUPPL.ementation and cancer, cardiovascular, and all-cause mortality in a German prospective cohort (EPIC-Heidelberg). Eur J Nutr, 51: 407 - 413.
15. Mursu, J, Robien, K, Harnack, L J, Park, K and Jacobs, D R Jr. 2011. Dietary Supplements and mortality rate in older women: the Iowa Women's Health Study. Arch Intern Med, 171: 1625 - 1633.
16. Macpherson, H, Pipingas, A and Pase, M P. 2013. Multivitamin-multimineral SUPPL.ementation and mortality: a meta-analysis of randomized controlled trials. Am J Clin Nutr, 97: 437 - 444.
17. Bjelakovic, G, Nikolova, D, Gluud, L L, Simonetti, R G and Gluud, C. 2012. Antioxidant Supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev, 3: CD007176
18. Murphy, S L, Xu, J and Kochanek, M A. Deaths: preliminary data for 2010. Natl Vital Stat Rep, 60 1 - 52. 2012
19. Lichtenstein, A H, Yetley, E A and Lau, J. 2008. Application of systematic review methodology to the field of nutrition. J Nutr, 138: 2297 - 2306.
20. Moher, D and Tricco, A C. 2008. Issues related to the conduct of systematic reviews: a focus on the nutrition field. Am J Clin Nutr, 88: 1191 - 1199.
21. Oxman, A D, Schunemann, H J and Fretheim, A. 2006. Improving the use of research evidence in guideline development: 8. Synthesis and presentation of evidence. Health Res Policy Syst, 4: 20
22. Shea, B J, Grimshaw, J M, Wells, G A, Boers, M, Andersson, N, Hamel, C, Porter, A C, Tugwell, P, Moher, D and Bouter, L M. 2007. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol, 7: 10
23. Blot, W J, Li, J Y, Taylor, P R, Guo, W, Dawsey, S, Wang, G Q, Yang, C S, Zheng, S F, Gail, M and Li, G Y. 1993. Nutrition intervention trials in Linxian, China: SUPPL.ementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst, 85: 1483 - 1492.
24. You, W C, Brown, L M, Zhang, L, Li, J Y, Jin, M L, Chang, Y S, Ma, J L, Pan, K F, Liu, W D, Hu, Y, Crystal-Mansour, S, Pee, D, Blot, WJ, Fraumeni, JF Jr, Xu, GW and Gail, MH. 2006. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst, 98: 974 - 983.
25. Gulati, R, Bailey, R, Prentice, A M, Brabin, B J and Owens, S. 2009. Haematological effects of multimicronutrient SUPPL.ementation in non-pregnant Gambian women. Eur J Clin Nutr, 63: 970 - 977.
26. Richer, S. 1996. Multicenter ophthalmic and nutritional age-related macular degeneration study-part 2: antioxidant intervention and conclusions. J Am Optom Assoc, 67: 30 - 49.
27. Richer, S, Stiles, W, Statkute, L, Pulido, J, Frankowski, J, Rudy, D, Pei, K, Tsipursky, M and Nyland, J. 2004. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant SUPPL.ementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry, 75: 216 - 230.
28. Avenell, A, Campbell, M K, Cook, J A, Hannaford, P C, Kilonzo, M M, McNeill, G, Milne, A C, Ramsay, C R, Seymour, D G, Stephen, A I and Vale, L D. 2005. Effect of multivitamin and multimineral Supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial. BMJ, 331: 324 - 329.
29. Pike, J and Chandra, R K. 1995. Effect of vitamin and trace element SUPPL.ementation on immune indices in healthy elderly. Int J Vitam Nutr Res, 65: 117 - 121.
30. Graat, J M, Schouten, E G and Kok, F J. 2002. Effect of daily vitamin E and multivitamin-mineral SUPPL.ementation on acute respiratory tract infections in elderly persons: a randomized controlled trial. JAMA, 288: 715 - 721.
31. Clinical Trial of Nutritional Supplements Age-Related Cataract Study Group, Maraini, G, Williams, S L, Sperduto, R D, Ferris, F, Milton, R C, Clemons, T E, Rosmini, F and Ferrigno, L A. 2008. A randomized, double-masked, placebo-controlled clinical trial of multivitamin SUPPL.ementation for age-related lens opacities. Clinical trial of nutritional Supplements and age-related cataract report no. 3. Ophthalmology, 115: 599 - 607.
32. Bogden, J D, Bendich, A, Kemp, F W, Bruening, K S, Shurnick, J H, Denny, T, Baker, H and Louria, D B. 1994. Daily micronutrient Supplements enhance delayed-hypersensitivity skin test responses in older people. Am J Clin Nutr, 60: 437 - 447.
33. Chandra, R K. 1992. Effect of vitamin and trace-element SUPPL.ementation on immune responses and infection in elderly subjects. Lancet, 340: 1124 - 1127.
34. Iso, H and Kubota, Y. 2007. Nutrition and disease in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC). Asian Pac J Cancer Prev, 8 (SUPPL.): 35 - 80.
35. Losonczy, K G, Harris, T B and Havlik, R J. 1996. Vitamin E and vitamin C SUPPL.ement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly. Am J Clin Nutr, 64: 190 - 196.
36. Muntwyler, J, Hennekens, C H, Manson, J E, Buring, J E and Gaziano, J M. 2002. Vitamin SUPPL.ement use in a low-risk population of US male physicians and subsequent cardiovascular mortality. Arch Intern Med, 162: 1472 - 1476.
37. Park, S Y, Murphy, S P, Wilkens, L R, Henderson, B E and Kolonel, L N. 2011. Multivitamin use and the risk of mortality and cancer incidence: the Multiethnic Cohort Study. Am J Epidemiol, 173: 906 - 914.
38. Pocobelli, G, Peters, U, Kristal, A R and White, E. 2009. Use of Supplements of multivitamins, vitamin C, and vitamin E in relation to mortality. Am J Epidemiol, 170: 472 - 483.
39. Rautiainen, S, Akesson, A, Levitan, E B, Morgenstern, R, Mittleman, M A and Wolk, A. 2010. Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women. Am J Clin Nutr, 92: 1251 - 1256.
40. Rimm, E B, Willett, W C, Hu, F B, Sampson, L, Colditz, G A, Manson, J E, Hennekens, C and Stampfer, M J. 1998. Folate and vitamin B6 from diet and Supplements in relation to risk of coronary heart disease among women. JAMA, 279: 359 - 364.
41. Sahyoun, N R, Jacques, P F and Russell, R M. 1996. Carotenoids, vitamins C and E, and mortality in an elderly population. Am J Epidemiol, 144: 501 - 511.
42. Watkins, M L, Erickson, J D, Thun, M J, Mulinare, J and Heath, C W Jr. 2000. Multivitamin use and mortality in a large prospective study. Am J Epidemiol, 152: 149 - 162.
43. U.S. Food and Drug Administration: FDA Adverse Event Reporting System (FAERS). 2012. Accessed at: http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Surveillance/AdverseDrugEffects/default.htm
44. U.S. Food and Drug Administration: FDA Food Safety Modernization Act (FSMA). 2013. Accessed at: http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Surveillance/AdverseDrugEffects/default.htm
45. Hercberg, S, Galan, P, Preziosi, P, Bertrais, S, Mennen, L, Malvy, D, Roussel, A M, Favier, A and Briancon, S. 2004. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med, 164: 2335 - 2342.
46. Li, J Y, Taylor, P R, Li, B, Dawsey, S, Wang, G Q, Ershow, A G, Guo, W, Liu, S F, Yang, C S and Shen, Q. 1993. Nutrition intervention trials in Linxian, China: multiple vitamin/mineral SUPPL.ementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia. J Natl Cancer Inst, 85: 1492 - 1498.
47. Jacques, P F and Tucker, K L. 2001. Are dietary patterns useful for understanding the role of diet in chronic disease?. Am J Clin Nutr, 73: 1 - 2.
48. Jacobs, D R Jr. and Steffen, L M. 2003. Nutrients, foods, and dietary patterns as exposures in research: a framework for food synergy. Am J Clin Nutr, 78: 508S - 513S.
49. Freudenheim, J L and Sinha, R. 1999. Symposium: interactions of diet and nutrition with genetic susceptibility in cancer. Overview. J Nutr, 129: 550S - 551S.
50. Tarasuk, V S and Brooker, A S. 1997. Interpreting epidemiologic studies of diet-disease relationships. J Nutr, 127: 1847 - 1852.
51. Byers, T and Lyle, B. 1999. The role of epidemiology in determining when evidence is sufficient to support nutrition recommendations. Summary statement. Am J Clin Nutr, 69: 1365S - 1367S.
52. Key, T J, Schatzkin, A, Willett, W C, Allen, N E, Spencer, E A and Travis, R C. 2004. Diet, nutrition and the prevention of cancer. Public Health Nutr, 7: 187 - 200.
53. Boffetta, P, McLaughlin, J K, La Vecchia, C, Tarone, R E, Lipworth, L and Blot, W J. 2008. False-positive results in cancer epidemiology: a plea for epistemological modesty. J Natl Cancer Inst, 100: 988 - 995.
54. Jacobs, E J, Connell, C J, Patel, A V, Chao, A, Rodriguez, C, Seymour, J, McCullough, M L, Calle, E E and Thun, M J. 2001. Multivitamin use and colon cancer mortality in the Cancer Prevention Study II cohort (United States). Cancer Causes Control, 12: 927 - 934.
55. Stevens, V L, McCullough, M L, Diver, W R, Rodriguez, C, Jacobs, E J, Thun, M J and Calle, E E. 2005. Use of multivitamins and prostate cancer mortality in a large cohort of US men. Cancer Causes Control, 16: 643 - 650.
56. Willett, W C and Stampfer, M J. 2001. Clinical practice. what vitamins should I be taking, doctor?. New Engl J Med, 345: 1819 - 1824.