Genome-wide association study of co-occurring anxiety in major depression

World Journal of Biological Psychiatry

Volumn 14, Issue 8, 2013, Pages 611-621

  Schosser, Alexandra ^a,n   Butler, Amy W ^a   Uher, Rudolf ^a   Ng, Mandy Y ^a   Cohen Woods, Sarah ^a   Craddock, Nick ^b   Owen, Mike J ^b   Korszun, Ania ^c   Gill, Michael ^d   Rice, John ^e   Hauser, Joanna ^f   Henigsberg, Neven ^g   Maier, Wolfgang ^h   Mors, Ole ⁱ   Placentino, Anna ^j   Rietschel, Marcella ^k   Souery, Daniel ^l   Preisig, Martin ^m   Craig, Ian W ^a   Farmer, Anne E ^a   Lewis, Cathryn M ^a   McGuffin, Peter ^a   more..

^a KING'S COLLEGE LONDON   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d TRINITY COLLEGE DUBLIN   (Ireland)

^e WASHINGTON UNIVERSITY   (United States)

^f POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^g UNIVERSITY OF ZAGREB   (Croatia)

^h UNIVERSITY OF BONN   (Germany)

ⁱ AARHUS UNIVERSITY HOSPITAL   (Denmark)

^j IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

^k CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^l UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^m LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

ⁿ MEDICAL UNIVERSITY OF VIENNA   (Austria)

more..

Author keywords

Anxiety; Association; Depression; GWAS; MDD

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; BETA 1 ADRENERGIC RECEPTOR; CHOLECYSTOKININ; DOPAMINE 3 RECEPTOR;

ADULT; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE EXPRESSION; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PHENOTYPE; PHOBIA; QUALITY CONTROL; SINGLE NUCLEOTIDE POLYMORPHISM;

ANXIETY; CASE-CONTROL STUDIES; COMORBIDITY; DEPRESSIVE DISORDER, MAJOR; EUROPE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; SEVERITY OF ILLNESS INDEX;

EID: 84887874921     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.3109/15622975.2013.782107     Document Type: Article

References (58)

1. American Psychiatric Association. 2000. Diagnostic and statistical manual of mental disorders (DSM-IV-TR), 4th ed. Text revision. Washington, DC: American Psychiatric Association.
2. Benjamini Y, Drai D, Elmer G., Kafkafi N, Golani I. 2001. Controlling the false discovery rate in behavior genetics research. Behav Brain Res 125: 279-284. (Pubitemid 33000466)
3. Biederman J, Petty C, Hirshfeld-Becker DR, Henin A., Faraone SV, Dang D, et al. 2006. A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression. Psychol Med 36: 1141-1152. (Pubitemid 44084017)
4. A receptors and gephyrin. J Neurosci 22: 4805-8013.
5. Chelly J, Kaplan JC, Maire P, Gautron S., Kahn A. 1988. Transcription of the dystrophin gene in human muscle and non-muscle tissues. Nature 333: 858-860.
6. Devlin B, Roeder K. 1999. Genomic control for association studies. Biometrics 55: 997-1004.
7. Dranovsky A, Hen R. 2006. Hippocampal neurogenesis: regulation by stress and antidepressants. Biol Psychiatry 59: 1136-1143.
8. Dudbridge F, Gusnanto A. 2008. Estimation of significance thresholds for genomewide association scans. Genet Epidemiol 32: 227-234. (Pubitemid 351550369)
9. Duman RS, Monteggia LM. 2006. A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59: 1116-1127.
10. Farmer A, Breen G, Brewster S., Craddock N, Gill M, Korszun A., et al. 2004. The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study. BMC Psychiatry 4: 42.
11. Fava M, Uebelacker LA, Alpert J.E., Nierenberg AA, Pava JA, Rosenbaum JF. 1997. Major depressive subtypes and treatment response. Biol Psychiatry 42: 568-576. (Pubitemid 27425475)
12. Fava M, Rosenbaum JF, Hoog S.L., Tepner RG, Kopp JB, Nilsson ME. 2000. Fluoxetine versus sertraline and paroxetine in major depression: tolerability and efficacy in anxious depression. J Affect Disord 59: 119-126. (Pubitemid 30317428)
13. Fava M, Rush AJ, Alpert J.E., Balasubramani GK, Wisniewski SR, Carmin CN, et al. 2008. Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR *D report. Am J Psychiatry 165: 342-351. (Pubitemid 351704490)
14. Fitzpatrick C, Barry C, Garvey C. 1986. Psychiatric disorder among boys with Duchenne muscular dystrophy. Dev Med Child Neurol 28: 589-595. (Pubitemid 16031324)
15. Graf ER, Zhang XZ, Jin S.X., Linhoff MW, Craig AM. 2004. Neurexins induce differentiation of GABA and glutamate post-synaptic specializations via neuroligins. Cell 119: 1013-1026. (Pubitemid 40037614)
16. Graves L, Dalvi A, Lucki I., Blendy JA, Abel T. 2002. Behavioral analysis of CREB alphadelta mutation on a B6/129 F1 hybrid background. Hippocampus 12: 18-26. (Pubitemid 34211243)
17. Gur TL, Conti AC, Holden J, Bechtholt A.J., Hill TE, Lucki I, et al. 2007. cAMP response element-binding protein deficiency allows for increased neurogenesis and a rapid onset of anti-depressant response. J Neurosci 27: 7860-7868. (Pubitemid 47093820)
18. Hebda-Bauer E.K., Watson SJ, Akil H. 2004. CREB deficient mice show inhibition and low activity in novel environments without changes in stress reactivity. Eur J Neurosci 20: 503-513. (Pubitemid 38969635)
19. Hettema JM. 2008. What is the genetic relationship between anxiety and depression? Am J Med Genet C Semin Med Genet 148C: 140-146. (Pubitemid 351705131)
20. Hettema JM, Prescott CA, Kendler KS. 2001. A population-based twin study of generalized anxiety disorder in men and women. J Nerv Ment Dis 189: 413-420. (Pubitemid 32730203)
21. Hirschfeld RM, Klerman GL. 1979. Personality attributes and affective disorders. Am J Psychiatry 136: 67-70. (Pubitemid 9085113)
22. Hirschfeld RM, Klerman GL, Lavori P, Keller M.B., Griffith P., Coryell W. 1989. The influence of alcoholism on the course of depression. J Affect Disord 16: 151-158. (Pubitemid 19062757)
23. Hoffman EP, Brown RHJ, Kunkel LM. 1987. Dystrophin: the protein product of Duchenne muscular dystrophy locus. Cell 51: 919-928.
24. Kang Y, Craig AM. 2006. Composition and assembly of GABAergic postsynaptic specializations. In: Dityatev A, El-Husseini A, editors. Molecular mechanisms of synaptogenesis. New York: Springer Science+ Business Media LLC. p. 277-295.
25. Kendler KS, Neale MC, Kessler R.C., Heath AC, et al. 1993. Panic disorder in women - A population-based twin study. Psychol Med 23: 397-406. (Pubitemid 23209235)
26. Kendler KS, Prescott CA, Myers J, Neale MC. 2003. The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Arch Gen Psychiatry 60: 929-937. (Pubitemid 37122313)
27. Kessler RC, Berglund P, Demler O., Jin R, Merikangas KR, Walters EE. 2005a. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62: 593-602. (Pubitemid 40973434)
28. Kessler RC, Chiu WT, Demler O, Walters EE. 2005b. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62: 617-627. (Pubitemid 40973437)
29. A receptors in mice lacking dystrophin (mdx mice). Eur J Neurosci 11: 4457-4462. (Pubitemid 30009278)
30. Komoto J, Usui S, Otsuki S., Terao A. 1984. Infantile autism and Duchenne musclular dystrophy. J Autism Dev Disord 14: 191-195. (Pubitemid 14029418)
31. Levi S, Grady RM, Henry M.D., Campbell KP, Sanes JR, Craig AM. 2002. Dystroglycan is selectively associated with inhibitory GABAergic synapses but is dispensable for their differentiation. J Neurosci 22: 4274-4285. (Pubitemid 37465642)
32. Lewis C, Ng MY, Butler A.W., Cohen-Woods S, Uher R, Pirlo K., et al. 2010. Genome-wide association study of major recurrent depression in the UK population. Am J Psychiatry 167: 949-957.
33. Lidov HG, Byers TJ, Watkins S.C., Kunkel LM. 1990. Localization of dystrophin to postsynaptic regions of central nervous system cortical neurons. Nature 348: 725-728. (Pubitemid 120015145)
34. McGuffin P, Katz R, Aldrich J. 1986. Past and present state examination: the assessment of 'lifetime ever 'psychopathology. Psychol Med 16: 461-465. (Pubitemid 16119211)
35. McGuffin P, Knight J, Breen G., Brewster S, Boyd PR, Craddock N, et al. 2005. Whole genome linkage scan of recurrent depressive disorder from the depression network study. Hum Mol Genet 14: 3337-3345. (Pubitemid 41672118)
36. Mddeldorp CM, Hottenga JJ, Slagboom P.E., Sullivan PF, de Geus EJ, Posthuma D, et al. 2008. Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype. Mol Psychiatry 13: 84-89. (Pubitemid 350275184)
37. Nakagawa S, Kim JE, Lee R, Chen J., Fujioka T, Malberg J, et al. 2002a. Localization of phosphorylated cAMP response element-binding protein in immature neurons of adult hippocampus. J Neurosci 22: 9868-9876. (Pubitemid 35332871)
38. Nakagawa S, Kim JE, Lee R, Malberg J.E., Chen J., Steffen C, et al. 2002b. Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. J Neurosci 22: 3673-3682. (Pubitemid 37465772)
39. Nelson EC, Grant JD, Bucholz K.K., Glowinski A., Madden PAF, Reich W, et al. 2000. Social phobia in a population-based female adolescent twin sample: co-morbidity and associated suicide-related symptoms. Psychol Med 30: 797-804. (Pubitemid 30623964)
40. Nelson JC. 2008. Anxious depression and response to treatment. Am J Psychiatry 165: 297-299. (Pubitemid 351704479)
41. Nelson JC. 2010. Anxiety does not predict response to duloxetine in major depression: results of a pooled analysis of individual patient data from 11 placebo-controlled trials. Depress Anxiety 27: 12-18.
42. Nelson JC, Delucchi K, Schneider LS. 2009. Anxiety does not predict response to antidepressant treatment in late life depression: results of a meta-analysis. Int J Geriatr Psychiatry 24: 539-544.
43. Price AL, Patterson NJ, Plenge R.M., Weinblatt ME, Shadick NA, Reich D. 2006. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38: 904-909. (Pubitemid 44141658)
44. Purcell S, Cherny SS, Sham PC. 2003. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19: 149-150. (Pubitemid 36150192)
45. Purcell S, Neale B, Todd-Brown K, Thomas L., Ferreira MA, Bender D, et al. 2007. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559-575. (Pubitemid 47330214)
46. Russel JM, Koran LM, Rush J, Hirschfeld R.M., Harrison W., Friedman ES, et al. 2001. Effect of concurrent anxiety on response to sertraline and imipramine in patients with chronic depression. Depress Anxiety 13: 18-27. (Pubitemid 32537090)
47. Schormair B, Kemlink D, Roeske D., Eckstein G, Xiong L, Lichtner P., et al. 2008. PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless leg syndrome. Nat Genet 40: 946-948.
48. Schosser A, Gaysina D, Cohen-Woods S, Chow P.C., Martucci L., Craddock N, et al. 2010. Association of DISC1 and TSNAX genes and affective disorders in the depression case-control DeCC) and bipolar affective case-control (BACCS) studies. Mol Psychiatry 15: 844-849.
49. Sham P, Sterne A, Purcell S., Cherny SS, Webster M, Rijsdijk FV, et al. 2000. GENESiS: creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings. Twin Res 3: 316-322. (Pubitemid 32126935)
50. Smoller JW, Gardner-Schuster E, Misiaszek M. 2008. Genetics of anxiety: would the genome recognize the DSM? Depress Anxiety 25: 368-377. (Pubitemid 351614571)
51. Sullivan PF, Neale MC, Kendler KS. 2000. Genetic epidemiology of major depression: Review and meta-analysis. Am J Psychiatry 157: 1552-1562.
52. Uher R, Huezo-Diaz P, Perroud N., Smith R, Reitschel M, Mors O., et al. 2009. Genetic predictors of response to anti-depressants in the GENDEP project. Pharmacogenomics J 9: 225-233.
53. Uher R, Demovsek MZ, Mors O, Hauser J., Souery D, Zobel A, et al. 2011. Melancholic, atypical and anxious depression subtypes and outcome of treatment with escitalopram and nortriptyline. J Affect Disord 132: 112-120.
54. Weissman MM, Wickramaratne P, Nomura Y., Warner V, Verdeli H, Pilowsky D.J., et al. 2005 Families at high and low risk for depression: a 3-generation study. Arch Gen Psychiatry 62: 29-36. (Pubitemid 40096068)
55. Wing JK, Babor T, Brugha T., Burke J, Cooper JE, Giel R, et al. 1990. SCAN. Schedules for clinical assessment in neuro-psychiatry. Arch Gen Psychiatry 47: 589-593. (Pubitemid 20189971)
56. Wittchen HU. 2000. Epidemiology of affective disorders. In: Contemporary Psychiatry. Vol 3. Helmchen H, Henn F, Lauter H, Sartorius N, editors. Heidelberg: Springer. p. 231-241.
57. World Health Organisation. 1993. The ICD-10 Classification of mental and behavioural disorders. Diagnostic criteria for research. Geneva: WHO.
58. Zhu K, Xu Y, Liu J., Xu Q, Ye H. 2011. Down syndrome cell adhesion molecule and its functions in neural development. Neurosci Bull 27: 45-52.