Glucose-stimulated insulin secretion: The hierarchy of its multiple cellular and subcellular mechanisms

Diabetologia

Volumn 56, Issue 12, 2013, Pages 2552-2555

  Meda, Paolo ^a   Schuit, Frans ^b  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Beta cells; Confocal microscopy; Connexin; Cx36; Exocytosis; Glucose; Heterogeneity; Insulin release; Pancreatic islets; Secretory granules; Stimulus secretion coupling

Indexed keywords

GLUCOSE;

ARTICLE; CELLULAR DISTRIBUTION; DISEASE SEVERITY; EXOCYTOSIS; GLUCOSE METABOLISM; IN VITRO STUDY; INSULIN RELEASE; INSULIN SYNTHESIS; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL;

ANIMALS; CELL MEMBRANE; EXOCYTOSIS; GLUCOSE; INSULIN; ISLETS OF LANGERHANS;

EID: 84887867113     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3073-z     Document Type: Article

References (21)

1. Henquin JC, Ravier MA, Nenquin M, Jonas JC, Gilon P (2003) Hierarchy of the beta-cell signals controlling insulin secretion. Eur J Clin Invest 33:742-750
2. Rorsman P, Braun M (2013) Regulation of insulin secretion in human pancreatic islets. Annu Rev Physiol 75:155-179
3. Pipeleers D, Kiekens R, Ling Z, Wilikens A, Schuit F (1994) Physiologic relevance of heterogeneity in the pancreatic beta-cell population. Diabetologia 37(Suppl 2):S57-S64
4. Bosco D, Haefliger JA, Meda P (2011) Connexins: key mediators of endocrine function. Physiol Rev 91:1393-1445
5. Schuit FC, In't Veld PA, Pipeleers DG (1988) Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells. Proc Natl Acad Sci U S A 85:3865-3869
6. Salomon D, Meda P (1986) Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells. Exp Cell Res 162:507-520
7. Soria B, Chanson M, Giordano E, Bosco D, Meda P (1991) Ion channels of glucose-responsive and -unresponsive beta-cells. Diabetes 40:1069-1078
8. Giordano E, Bosco D, Cirulli V, Meda P (1991) Repeated glucose stimulation reveals distinct and lasting secretion patterns of individual rat pancreatic B cells. J Clin Invest 87:2178-2185
9. Stefan Y, Meda P, Neufeld M, Orci L (1987) Stimulation of insulin secretion reveals heterogeneity of pancreatic B cells in vivo. J Clin Invest 80:175-183
10. 2+ and insulin oscillations, and basal insulin release. Diabetes 54:1798-1807
11. Meda P (2012) The in vivo β-to-β-cell chat room: connexin connections matter. Diabetes 61:1656-1658
12. Aoyagi K, Ohara-Imaizumi M, Nagamatsu S (2011) Regulation of resident and newcomer insulin granules by calcium and SNARE proteins. Front Biosci 16:1197-1210
13. Low JT, Mitchell JM, Do OH et al (2013) Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell. Diabetologia. doi: 10.1007/s00125-013-3019-5
14. Takahashi N, Kishimoto T, Nemoto T, Kadowaki T, Kasai H (2002) Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet. Science 297:1349-1352
15. Schraenen A, Lemaire K, de Faudeur G et al (2010) Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy. Diabetologia 53:2589-2599
16. De Vos A, Heimberg H, Quartier E et al (1995) Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. J Clin Invest 96:2489-2495
17. Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, Caicedo A (2006) The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci U S A 103:2334-2339
18. Dai C, Brissova M, Hang Y et al (2012) Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets. Diabetologia 55:707-718
19. Wojtusciszyn A, Armanet M, Morel P, Berney T, Bosco D (2008) Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts. Diabetologia 51:1843-1852
20. Serre-Beinier V, Bosco D, Zulianello L et al (2009) Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression. Hum Mol Genet 18:428-439
21. Hellman B, Salehi A, Gylfe E, Dansk H, Grapengiesser E (2009) Glucose generates coincident insulin and somatostatin pulses and antisynchronous glucagon pulses from human pancreatic islets. Endocrinology 150:5334-5340