A phenotypic screening approach in cord blood-derived mast cells to identify anti-inflammatory compounds

Journal of Biomolecular Screening

Volumn 18, Issue 10, 2013, Pages 1223-1233

  Kaur, Rejbinder ^a   Sloan, Lisa A ^a   Blanchard, Andy D ^a   Smith, Janet L ^a   Churcher, Ian ^a   Wayne, Gareth J ^a   Ludbrook, Steven B ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

inflammation; mast cell; phenotypic screen; prostaglandin D2; tryptase

Indexed keywords

ANTIINFLAMMATORY AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM CHANNEL BLOCKING AGENT; FENOTEROL; ISOPRENALINE; NVP QAB 205; PROSTAGLANDIN D2; PROTEIN KINASE SYK INHIBITOR; SYNTA 66; TERBUTALINE; TRYPTASE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; CYTOLOGY; DRUG DETERMINATION; DRUG SCREENING; ENZYME ASSAY; ENZYME RELEASE; HUMAN; HUMAN CELL; MAST CELL; MAST CELL DEGRANULATION; MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; UMBILICAL CORD BLOOD;

INFLAMMATION; MAST CELL; PHENOTYPIC SCREEN; PROSTAGLANDIN D2; TRYPTASE;

ANTI-INFLAMMATORY AGENTS; BIOLOGICAL ASSAY; CELL DEGRANULATION; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; FETAL BLOOD; HUMANS; INHIBITORY CONCENTRATION 50; MAST CELLS; PHENOTYPE; PROSTAGLANDIN D2; SMALL MOLECULE LIBRARIES;

EID: 84887863639     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113500073     Document Type: Article

References (29)

1. Gilfillan A. M., Beaven M. A.. Regulation of Mast Cell Responses in Health and Disease. Crit. Rev. Immunol. 2011 ; 31: 475-529
2. Sigal L. H.. Basic Science for the Clinician 53: Mast Cells. J. Clin. Rheumatol. 2011 ; 17: 395-400
3. Kovarova M., Rivera J.. A Molecular Understanding of Mast Cell Activation and the Promise of Anti-Allergic Therapeutics. Curr. Med. Chem. 2004 ; 11: 2083-2091
4. Beunk L., Verwoerd A., van Overveld F. J., et al. Role of Mast Cells in Mucosal Diseases: Current Concepts and Strategies for Treatment. Expert Rev. Clin. Immunol. 2013 ; 9: 53-63
5. Schulman E. S., Kagey-Sobotka A., MacGlashan D. W., et al. Heterogeneity of Human Mast Cells. J. Immunol. 1983 ; 131: 1936-1941
6. Denyer J., Patel V.. Syk Kinase Inhibitors in Allergic Diseases. Drug News Perspect. 2009 ; 22: 146-150
7. Patou J., Holtappels G., Affleck K., et al. Syk-Kinase Inhibition Prevents Mast Cell Activation in Nasal Polyps. Rhinology. 2011 ; 49: 100-106
8. Rossi A. B., Herlaar E., Braselmann S., et al. Identification of the Syk Kinase Inhibitor R112 by a Human Mast Cell Screen. J. Allergy Clin. Immunol. 2006 ; 118: 749-755
9. Di Capite J. L., Bates G. J., Parekh A. B.. Mast Cell CRAC Channel as a Novel Therapeutic Target in Allergy. Curr. Opin. Allergy Clin. Immunol. 2011 ; 11: 33-38
10. Rice L. V., Bax H. J., Russell L. J., et al. Characterization of Selective Calcium-Release Activated Calcium Channel Blockers in Mast Cells and T-cells from Human, Rat, Mouse and Guinea-Pig Preparations. Eur. J. Pharmacol. 2013 ; 704: 49-57
11. Moon T. C., St.Laurent C. D., Morris K. E., et al. Advances in Mast Cell Biology: New Understanding of Heterogeneity and Function. Mucosal Immunol. 2010 ; 3: 111-128
12. Cochrane D. E., Carraway R. E., Harrington K., et al. HMC-1 Human Mast Cells Synthesize Neurotensin (NT) Precursor, Secrete Bioactive NT-like Peptide(s) and Express NT Receptor NTS1. Inflamm. Res. 2011 ; 60: 1139-1151
13. Butterfield J. H., Weiler D., Dewald G., et al. Establishment of an Immature Mast Cell Line from a Patient with Mast Cell Leukemia. Leuk. Res. 1988 ; 12: 345-355
14. Kirshenbaum A. S., Akin C., Wu Y., et al. Characterization of Novel Stem Cell Factor Responsive Human Mast Cell Lines LAD 1 and 2 Established from a Patient with Mast Cell Sarcoma/Leukemia; Activation following Aggregation of FcepsilonRI or FcgammaRI. Leuk. Res. 2003 ; 27: 677-682
15. Vera M. E., Persia F. A., Mariani M. L., et al. Activation of Human Leukemic Mast Cell Line LAD2 Is Modulated by Dehydroleucodine and Xanthatin. Leuk. Lymphoma. 2012 ; 53: 1795-1803
16. Ochi H., Hirani W. M., Yuan Q., et al. T Helper Cell Type 2 Cytokine-Mediated Comitogenic Responses and CCR3 Expression during Differentiation of Human Mast Cells In Vitro. J. Exp. Med. 1999 ; 190: 267-280
17. Saito H., Ebisawa M., Sakaguchi N., et al. Characterization of Cord-Blood-Derived Human Mast Cells Cultured in the Presence of Steel Factor and Interleukin-6. Int. Arch. Allergy Immunol. 1995 ; 107: 63-65
18. Radinger M., Jensen B. M., Kuehn H. S., et al. Generation, Isolation, and Maintenance of Human Mast Cells and Mast Cell Lines Derived from Peripheral Blood or Cord Blood. Curr. Protoc. Immunol. 2010 ;: 37
19. Kirshenbaum A. S., Goff J. P., Semere T., et al. Demonstration That Human Mast Cells Arise from a Progenitor Cell Population That Is CD34(+), c-kit(+), and Expresses Aminopeptidase N (CD13). Blood. 1999 ; 94: 2333-2342
20. Schwartz L. B.. Monoclonal Antibodies against Human Mast Cell Tryptase Demonstrate Shared Antigenic Sites on Subunits of Tryptase and Selective Localization of the Enzyme to Mast Cells. J. Immunol. 1985 ; 134: 526-531
21. Schwartz L. B., Bradford T. R.. Regulation of Tryptase from Human Lung Mast Cells by Heparin: Stabilization of the Active Tetramer. J. Biol. Chem. 1986 ; 261: 7372-7379
22. Di S. A., Rovedatti L., Kaur R., et al. Targeting Gut T Cell Ca2+ Release-Activated Ca2+ Channels Inhibits T Cell Cytokine Production and T-box Transcription Factor T-bet in Inflammatory Bowel Disease. J. Immunol. 2009 ; 183: 3454-3462
23. Kay L. J., Peachell P. T.. Mast Cell Beta2-Adrenoceptors. Chem. Immunol. Allergy. 2005 ; 87: 145-153
24. Kay L. J., Rostami-Hodjegan A., Suvarna S. K., et al. Influence of Beta2-Adrenoceptor Gene Polymorphisms on Beta2-Adrenoceptor-Mediated Responses in Human Lung Mast Cells. Br. J. Pharmacol. 2007 ; 152: 323-331
25. Arima M., Fukuda T.. Prostaglandin D(2) and T(H)2 Inflammation in the Pathogenesis of Bronchial Asthma. Korean J. Intern. Med. 2011 ; 26: 8-18
26. Leveridge M. V., Bardera A. I., LaMarr W., et al. Lead Discovery for Microsomal Prostaglandin E Synthase Using a Combination of High-Throughput Fluorescent-Based Assays and RapidFire Mass Spectrometry. J. Biomol. Screen. 2012 ; 17: 641-650
27. Lee J., Bogyo M.. Target Deconvolution Techniques in Modern Phenotypic Profiling. Curr. Opin. Chem. Biol. 2013 ; 17: 118-126
28. Kruse U., Pallasch C. P., Bantscheff M., et al. Chemoproteomics-Based Kinome Profiling and Target Deconvolution of Clinical Multi-Kinase Inhibitors in Primary Chronic Lymphocytic Leukemia Cells. Leukemia. 2011 ; 25: 89-100
29. Houck K. A., Dix D. J., Judson R. S., et al. Profiling Bioactivity of the ToxCast Chemical Library Using BioMAP Primary Human Cell Systems. J. Biomol. Screen. 2009 ; 14: 1054-1066