Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site

Journal of Biological Chemistry

Volumn 288, Issue 46, 2013, Pages 33124-33135

  Kvist, Trine ^a   Steffensen, Thomas Bielefeldt ^a   Greenwood, Jeremy R ^b   Tabrizi, Fatemeh Mehrzad ^a   Hansen, Kasper B ^c   Gajhede, Michael ^a   Pickering, Darryl S ^a   Traynelis, Stephen F ^c   Kastrup, Jette Sandholm ^a   Bräuner Osborne, Hans ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b SCHRÖDINGER INC   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPETITIVE INTERACTIONS; EXCITATORY NEUROTRANSMISSION; LIGAND BINDING DOMAIN; LIGAND-GATED ION CHANNELS; N-METHYL-D-ASPARTATE; PHARMACOLOGICAL CHARACTERIZATION; RECEPTOR ANTAGONISTS; REPLACEMENT STRATEGY;

BINDING ENERGY; LIGANDS;

AMINO ACIDS;

1 THIOXO 1,2 DIHYDRO[1,2,4]TRIAZOLO[4,3 A]QUINOXALIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2C; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2D; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 3A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 3B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PURIFICATION; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BIOISOSTER; COMPETITIVE ANTAGONIST; CRYSTAL STRUCTURE; GLYCINE SITE; ION CHANNELS; LIGAND-BINDING PROTEIN; MOLECULAR PHARMACOLOGY; NEUROTRANSMITTER RECEPTORS; NMDA RECEPTOR; SCHILD ANALYSIS;

ANIMALS; BINDING SITES; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; QUINOXALINES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; TRIAZOLES; XENOPUS LAEVIS;

EID: 84887836929     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.480210     Document Type: Article

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