Isometric contraction of dupuytren's myofibroblasts is inhibited by blocking intercellular junctions

Journal of Investigative Dermatology

Volumn 133, Issue 12, 2013, Pages 2664-2671

  Verhoekx, Jennifer S N ^a,b   Verjee, Liaquat S ^a   Izadi, David ^a   Chan, James K K ^a   Nicolaidou, Vicky ^a   Davidson, Dominique ^c   Midwood, Kim S ^a   Nanchahal, Jagdeep ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c ST JOHN'S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; COLLAGEN;

ARTICLE; CELL ACTIVITY; CELL COMMUNICATION; CELL JUNCTION; CONTROLLED STUDY; DOWN REGULATION; DUPUYTREN CONTRACTURE; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; MATRICARIA; MUSCLE ISOMETRIC CONTRACTION; MYOFIBROBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCAR FORMATION; SYNCYTIUM; WOUND CONTRACTION;

EID: 84887821278     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.219     Document Type: Article

References (29)

1. Asazuma-Nakamura Y, Dai P, Harada Y et al. (2009) Cx43 contributes to TGF-beta signaling to regulate differentiation of cardiac fibroblasts into myofibroblasts. Exp Cell Res 315:1190-9
2. Au K, Ehrlich HP (2007) Does rat granulation tissue maturation involve gap junction communications Plast Reconstr Surg 120:91-9
3. Bisson MA, Mudera V, McGrouther DA et al. (2004) The contractile properties and responses to tensional loading of Dupuytrens disease-derived fibroblasts are altered: a cause of the contracture Plast Reconstr Surg 113:611-21
4. Cooper JA (1987) Effects of cytochalasin and phalloidin on actin. J Cell Biol 105:1473-8
5. Dibenedetti DB, Nguyen D, Zografos L et al. (2011) Prevalence, incidence, and treatments of Dupuytrens disease in the United States: results from a population-based study. Hand (NY) 6:149-58
6. Ehrlich HP, Diez T (2003) Role for gap junctional intercellular communications in wound repair. Wound Repair Regen 11:481-9
7. Ermakov YA, Kamaraju K, Sengupta K et al. (2010) Gadolinium ions block mechanosensitive channels by altering the packing and lateral pressure of anionic lipids. Biophys J 98:1018-27
8. Follonier L, Schaub S, Meister JJ et al. (2008) Myofibroblast communication is controlled by intercellular mechanical coupling. J Cell Sci 121:3305-16
9. Guan X, Wilson S, Schlender KK et al. (1996) Gap-junction disassembly and connexin 43 dephosphorylation induced by 18 beta-glycyrrhetinic acid. Mol Carcinog 16:157-64
10. Haswell ES, Phillips R, Rees DC (2011) Mechanosensitive channels: what can they do and how do they do it Structure 19:1356-69
11. Hatta K, Takeichi M (1986) Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development. Nature 320:447-9
12. Heinrich M, Oberbach A, Schlichting N et al. (2011) Cytokine effects on gap junction communication and connexin expression in human bladder smooth muscle cells and suburothelial myofibroblasts. PLoS One 6:e20792
13. Hinz B, Mastrangelo D, Iselin CE et al. (2001) Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation. Am J Pathol 159:1009-20
14. Hinz B, Pittet P, Smith-Clerc J et al. (2004) Myofibroblast development is characterized by specific cell-cell adherens junctions. Mol Biol Cell 15:4310-20
15. Ko KS, Arora PD, McCulloch CA (2001) Cadherins mediate intercellular mechanical signaling in fibroblasts by activation of stretch-sensitive calcium-permeable channels. J Biol Chem 276:35967-77
16. Mori R, Power KT, Wang CM et al. (2006) Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration. J Cell Sci 119:5193-203
17. Moyer KE, Banducci DR, Graham WP 3rd et al. (2002) Dupuytrens disease: physiologic changes in nodule and cord fibroblasts through aging in vitro. Plast Reconstr Surg 110:187-93
18. Neuhaus J, Heinrich M, Schwalenberg T et al. (2009) TGF-beta1 inhibits Cx43 expression and formation of functional syncytia in cultured smooth muscle cells from human detrusor. Eur Urol 55:491-7
19. Pittet P, Lee K, Kulik AJ et al. (2008) Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds. J Cell Sci 121:877-86
20. Rama A, Matsushita T, Charolidi N et al. (2006) Up-regulation of connexin43 correlates with increased synthetic activity and enhanced contractile differentiation in TGF-beta-treated human aortic smooth muscle cells. Eur J Cell Biol 85:375-86
21. Rombouts JJ, Noel H, Legrain Y et al. (1989) Prediction of recurrence in the treatment of Dupuytrens disease: evaluation of a histologic classification. J Hand Surg Am 14:644-52
22. Skalli O, Ropraz P, Trzeciak A et al. (1986) A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 103:2787-96
23. Sukharev SI, Blount P, Martinac B et al. (1997) Mechanosensitive channels of Escherichia coli: the MscL gene, protein, and activities. Annu Rev Physiol 59:633-57
24. Townley WA, Cambrey AD, Khaw PT et al. (2009) The role of an MMP inhibitor in the regulation of mechanical tension by Dupuytrens disease fibroblasts. J Hand Surg Eur Vol 34:783-7
25. Verjee LS, Midwood K, Davidson D et al. (2009) Myofibroblast distribution in Dupuytrens cords: correlation with digital contracture. J Hand Surg Am 34:1785-94
26. Verjee LS, Midwood K, Davidson D et al. (2010) Post-transcriptional regulation of alpha-smooth muscle actin determines the contractile phenotype of Dupuytrens nodular cells. J Cell Physiol 224:681-90
27. Wei CJ, Francis R, Xu X et al. (2005) Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells. J Biol Chem 280:19925-36
28. Yap AS, Brieher WM, Gumbiner BM (1997) Molecular and functional analysis of cadherin-based adherens junctions. Annu Rev Cell Dev Biol 13:119-46
29. Zhang Y, Wang H, Kovacs A et al. (2010) Reduced expression of Cx43 attenuates ventricular remodeling after myocardial infarction via impaired TGF-beta signaling. Am J Physiol Heart Circ Physiol 298:H477-87