The role of an MMP inhibitor in the regulation of mechanical tension by Dupuytren's disease fibroblasts

Journal of Hand Surgery: European Volume

Volumn 34, Issue 6, 2009, Pages 783-787

  Townley, W A ^a   Cambrey, A D ^a   Khaw, P T ^a   Grobbelaar, A O ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

Dupuytren's disease; Fibroblast; Ilomastat; Matrix remodelling; MMP; Tension

Indexed keywords

CYTOCHALASIN D; ENZYME INHIBITOR; ILOMASTAT; INDOLE DERIVATIVE; MATRIX METALLOPROTEINASE; NUCLEIC ACID SYNTHESIS INHIBITOR;

ARTICLE; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; DUPUYTREN CONTRACTURE; FIBROBLAST; HUMAN; PATHOLOGY;

CELLS, CULTURED; CYTOCHALASIN D; DUPUYTREN CONTRACTURE; ENZYME INHIBITORS; FIBROBLASTS; HUMANS; INDOLES; MATRIX METALLOPROTEINASES; NUCLEIC ACID SYNTHESIS INHIBITORS;

EID: 74549176823     PISSN: 17531934     EISSN: None     Source Type: Journal    
DOI: 10.1177/1753193409345188     Document Type: Article

References (28)

1. Aarabi, S, KA Bhatt, and Y Shi (2007). Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. Faseb J, 21, 3250-3261. (Pubitemid 47565543)
2. Augoff, K, K Ratajczak, J Gosk, R Tabola, and R Rutowski (2006). Gelatinase A activity in Dupuytren's disease. J Hand Surg Am, 31, 1635-1639.
3. Bisson, MA, DA McGrouther, V Mudera, and AO Grobbelaar (2003). The different characteristics of Dupuytren's disease fibroblasts derived from either nodule or cord: expression of alpha-smooth muscle actin and the response to stimulation by TGF-beta1. J Hand Surg Br, 28, 351-356.
4. Bisson, MA, V Mudera, DA McGrouther, and AO Grobbelaar (2004). The contractile properties and responses to tensional loading of Dupuytren's disease-derived fibroblasts are altered: a cause of the contracture? Plast Reconstr Surg, 113, 611-621.
5. Citron, N, and A Hearnden (2003). Skin tension in the aetiology of Dupuytren's disease; a prospective trial. J Hand Surg Br, 28, 528-530.
6. Daniels, JT, AD Cambrey, and NL Occleston (2003). Matrix metalloproteinase inhibition modulates fibroblast-mediated matrix contraction and collagen production in vitro. Invest Ophthalmol Vis Sci, 44, 1104-1110.
7. Dias, JJ, and J Braybrooke (2006). Dupuytren's contracture: an audit of the outcomes of surgery. J Hand Surg Br, 31, 514-521.
8. Eastwood, M, DA McGrouther, and RA Brown (1994). A culture force monitor for measurement of contraction forces generated in human dermal fibroblast cultures: evidence for cell-matrix mechanical signalling. Biochim Biophys Acta, 1201, 186-192.
9. Ehrlich, HP, A Desmouliere, and RF Diegelmann (1994). Morphological and immunochemical differences between keloid and hypertrophic scar. Am J Pathol, 145, 105-113.
10. Ehrlich, HP, and JB Rajaratnam (1990). Cell locomotion forces versus cell contraction forces for collagen lattice contraction: an in vitro model of wound contraction. Tissue Cell, 22, 407-417.
11. Gabbiani, G, and G Majno (1972). Dupuytren's contracture: fibroblast contraction? An ultrastructural study. Am J Pathol, 66, 131-146.
12. Harris, AK, D Stopak, and P Wild (1981). Fibroblast traction as a mechanism for collagen morphogenesis. Nature, 290, 249-251.
13. Howard, JC, VM Varallo, and DC Ross (2003). Elevated levels of betacatenin and fibronectin in three-dimensional collagen cultures of Dupuytren's disease cells are regulated by tension in vitro. BMC Musculoskelet Disord, 4, 16.
14. Hueston, JT, JV Hurley, and S Whittingham (1976). The contracting fibroblast as a clue to Dupuytren's contracture. Hand, 8, 10-12.
15. Johnston, P, AJ Chojnowski, RK Davidson, GP Riley, ST Donell, and IM Clark (2007). A complete expression profile of matrix-degrading metalloproteinases in Dupuytren's disease. J Hand Surg Am, 32, 343-351.
16. Johnston, P, D Larson, IM Clark, and AJ Chojnowski (2008). Metalloproteinase gene expression correlates with clinical outcome in Dupuytren's disease. J Hand Surg Am, 33, 1160-1167.
17. Marenzana, M, N Wilson-Jones, V Mudera, and RA Brown (2006). The origins and regulation of tissue tension: identification of collagen tensionfixation process in vitro. Exp Cell Res, 312, 423-433.
18. Mudera, VC, R Pleass, and M Eastwood (2000). Molecular responses of human dermal fibroblasts to dual cues: contact guidance and mechanical load. Cell Motil Cytoskeleton, 45, 1-9.
19. Nagase, H, R Visse, and G Murphy (2006). Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res, 69, 562-573.
20. Phillips, JA, CA Vacanti, and LJ Bonassar (2003). Fibroblasts regulate contractile force independent of MMP activity in 3D-collagen. Biochem Biophys Res Commun, 312, 725-732.
21. Qian, A, RA Meals, J Rajfer, and NF Gonzalez-Cadavid (2004). Comparison of gene expression profiles between Peyronie's disease and Dupuytren's contracture. Urology, 64, 399-404.
22. Sheridan, CM, NL Occleston, P Hiscott, CH Kon, PT Khaw, and I Grierson (2001). Matrix metalloproteinases: a role in the contraction of vitreo-retinal scar tissue. Am J Pathol, 159, 1555-1566.
23. Sternlicht, MD, and Z Werb (2001). How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol, 17, 463-516.
24. Tayebjee, MH, GY Lip, and RJ MacFadyen (2005). Matrix metalloproteinases in coronary artery disease: clinical and therapeutic implications and pathological significance. Curr Med Chem, 12, 917-925.
25. Tomasek, JJ, G Gabbiani, B Hinz, C Chaponnier, and RA Brown (2002). Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol, 3, 349-363.
26. Townley, WA, AD Cambrey, PT Khaw, and AO Grobbelaar (2008). Matrix metalloproteinase inhibition reduces contraction by Dupuytren's fibroblasts. J Hand Surg Am, 33, 1608-1616.
27. Tranquillo, RT (1999). Self-organization of tissue-equivalents: the nature and role of contact guidance. Biochem Soc Symp, 65, 27-42.
28. Wong, TT, AL Mead, and PT Khaw (2003). Matrix metalloproteinase inhibition modulates postoperative scarring after experimental glaucoma filtration surgery. Invest Ophthalmol Vis Sci, 44, 1097-1103.