Exercise lowers postprandial glucose but not fasting glucose in type 2 diabetes: A meta-analysis of studies using continuous glucose monitoring

Diabetes/Metabolism Research and Reviews

Volumn 29, Issue 8, 2013, Pages 593-603

  Macleod, S F ^a   Terada, T ^a   Chahal, B S ^a   Boule N G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Blood glucose; Diabetes mellitus; Exercise; Meta analysis; Type 2

Indexed keywords

ANTIDIABETIC AGENT; GLUCOSE; INSULIN;

AEROBIC EXERCISE; ARTICLE; BLOOD GLUCOSE MONITORING; CYCLING; DIABETIC DIET; EMBASE; ENDURANCE TRAINING; FASTING BLOOD GLUCOSE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; KINESIOTHERAPY; LONG TERM CARE; MEDLINE; META ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESISTANCE TRAINING; SHORT COURSE THERAPY; SYSTEMATIC REVIEW; TREADMILL EXERCISE; WALKING;

BLOOD GLUCOSE; DIABETES MELLITUS; EXERCISE; META-ANALYSIS; TYPE 2;

BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; EXERCISE; FASTING; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MONITORING, AMBULATORY; POSTPRANDIAL PERIOD;

EID: 84887780475     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.2461     Document Type: Article

References (47)

1. Umpierre D, Ribeiro PAB, Kramer CK, et al. Physical Activity Advice Only or Structured Exercise Training and Association With HbA1c Levels in Type 2 Diabetes A Systematic Review and Meta-analysis. JAMA 2011; 305(17): 1790-1799.
2. Snowling NJ, Hopkins WG. Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients. Diabetes Care 2006; 29(11): 2518-2527.
3. Boulé NG, Haddad E, Kenny GP, Wells GA, Sigal RJ. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus. JAMA 2001; 286(10): 1218-1227.
4. Thomas D, Elliott E, Naughton G. Exercise for type 2 diabetes mellitus. Cochrane Database Syst Rev 2006; 3. Art. No.: CD002968. DOI: 10.1002/14651858.CD002968.pub2
5. Saudek CD, Derr RL, Kalyani RR. Assessing glycemia in diabetes using self-monitoring blood glucose and hemoglobin A1c. JAMA 2006; 295(14): 1688-1697.
6. Stratton IM, Adler AI, Neil HAW, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000; 321(7258): 405-412.
7. Cavalot F, Pagliarino A, Valle M, et al. Postprandial Blood Glucose Predicts Cardiovascular Events and All-Cause Mortality in Type 2 Diabetes in a 14-Year Follow-Up. Diabetes Care 2011; 34(10): 2237-2243.
8. Jackson C, Yudkin J, Forrest R. A comparison of the relationships of the glucose tolerance test and the glycated haemoglobin assay with diabetic vascular disease in the community. The Islington Diabetes Survey. Diabetes Res Clin Pract 1992; 17(2): 111-123.
9. De Vegt F, Dekker J, Ruhe H, et al. Hyperglycaemia is associated with all-cause and cardiovascular mortality in the Hoorn population: the Hoorn Study. Diabetologia 1999; 42(8): 926-931.
10. Meigs JB, Nathan DM, D'Agostino RB Sr, Wilson PW. Fasting and postchallenge Glycemia and cardiovascular disease risk the framingham offspring Study. Diabetes Care 2002; 25(10): 1845-1850.
11. Ceriello A, Taboga C, Tonutti L, et al. Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation effects of short-and long-term Simvastatin treatment. Circulation 2002; 106(10): 1211-1218.
12. Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA 2006; 295(14): 1681-1687.
13. Higgins J, Green S. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011].The Cochrane Collaboration, 2011. Chapter 7: Selecting studies and collecting data.
14. Praet SF, Manders RJ, Lieverse AG, et al. Influence of acute exercise on hyperglycemia in insulin-treated type 2 diabetes. Med Sci Sports Exerc 2006; 38(12): 2037-2044.
15. Manders RJ, Van Dijk JW, van Loon LJ. Low-intensity exercise reduces the prevalence of hyperglycemia in type 2 diabetes. Med Sci Sports Exerc 2010; 42(2): 219-225.
16. van Dijk JW, Tummers K, Stehouwer CDA, Hartgens F, van Loon LJC. Exercise Therapy in Type 2 Diabetes Is daily exercise required to optimize glycemic control? Diabetes Care 2012; 35(5): 948-954.
17. Mikus CR, Oberlin DJ, Libla J, Boyle LJ, Thyfault JP. Glycaemic control is improved by 7days of aerobic exercise training in patients with type 2 diabetes. Diabetologia 2012; 55(5): 1417-1423.
18. Higgins J, Green S. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011].The Cochrane Collaboration, 2011. Chapter 16: Special topics in statistics.
19. Higgins J, Green S. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011].The Cochrane Collaboration, 2011. Chapter 10: Addressing reporting biases.
20. Gillen JB, Little JP, Punthakee Z, Tarnopolsky MA, Riddell MC, Gibala MJ. Acute high-intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycemia in patients with type 2 diabetes. Diabetes Obes Metab 2012; 14(6): 575-577.
21. MacDonald AL, Philp A, Harrison M, Bone AJ, Watt PW. Monitoring exercise-induced changes in glycemic control in type 2 diabetes. Med Sci Sports Exerc 2006; 38(2): 201-207.
22. van Dijk JW, Manders RJ, Tummers K, et al. Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients. Diabetologia 2012; 55(5): 1273-1282.
23. Newton PG, White NH. Impact of acute moderate intensity exercise on blood glucose (BG) in youth with type 2 diabetes mellitus (T2D). Diabetes 2012; 61: A334-A335.
24. Higgins J, Green S. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011].The Cochrane Collaboration, 2011. Chapter 9: Analysing data and undertaking meta-analyses.
25. Little JP, Gillen JB, Percival ME, et al. Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes. J Appl Physiol 2011; 111(6): 1554-1560.
26. Cauza E, Hanusch-Enserer U, Strasser B, Kostner K, Dunky A, Haber P. Strength and endurance training lead to different post exercise glucose profiles in diabetic participants using a continuous subcutaneous glucose monitoring system. Eur J Clin Invest 2005; 35(12): 745-751.
27. Karstoft K, Winding K, Knudsen SH, et al. The effects of free-living interval-walking training on glycemic control, body composition, and physical fitness in type 2 diabetic patients: A randomized, controlled trial. Diabetes Care 2013; 36(2): 228-236.
28. Bacchi E, Negri C, Trombetta M, et al. Differences in the Acute Effects of Aerobic and Resistance Exercise in Subjects with Type 2 Diabetes: Results from the RAED2 Randomized Trial. PLoS One 2012 Article Number: e4; 7(12), 2012:ate of Pubaton: 05 e 2012.
29. Colberg SR, Sigal RJ, Fernhall B, et al. Exercise and Type 2 Diabetes The American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care 2010; 33(12): 2692-2696.
30. Hordern MD, Dunstan DW, Prins JB, Baker MK, Singh MAF, Coombes JS. Exercise prescription for patients with type 2 diabetes and pre-diabetes: A position statement from Exercise and Sport Science Australia. J Sci Med Sport 2012; 15(1): 25-31.
31. Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. Canadian Diabetes Association 2008 clinical practice guidelines for the prevention and management of diabetes in Canada. Can J Diabetes 2008; 32(suppl 1): S1-S201.
32. Perseghin G, Price TB, Petersen KF, et al. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med 1996; 335(18): 1357-1362.
33. Kjaer M, Hollenbeck CB, Frey-Hewitt B, Galbo H, Haskell W, Reaven GM. Glucoregulation and hormonal responses to maximal exercise in non-insulin-dependent diabetes. J Appl Physiol 1990; 68(5): 2067-2074.
34. DiPietro L, Dziura J, Yeckel CW, Neufer PD. Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. J Appl Physiol 2006; 100(1): 142-149.
35. Abdul-Ghani MA, Jenkinson CP, Richardson DK, Tripathy D, DeFronzo RA. Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance. Diabetes 2006; 55(5): 1430-1435.
36. Nathan DM, Davidson MB, DeFronzo RA, et al. Impaired fasting glucose and impaired glucose tolerance. Diabetes Care 2007; 30(3): 753-759.
37. Wahren J, Ekberg K. Splanchnic regulation of glucose production. Annu Rev Nutr 2007; 27: 329-345.
38. Winnick JJ, Sherman WM, Habash DL, et al. Short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole-body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivity. J Clin Endocrinol Metab 2008; 93(3): 771-778.
39. Boulé NG, Weisnagel SJ, Lakka TA, et al. Effects of exercise training on glucose homeostasis. Diabetes Care 2005; 28(1): 108-114.
40. Rönnemaa T, Mattila K, Lehtonen A, Kallio V. A Controlled Randomized Study on the Effect of Long-term Physical Exercise on the Metabolic Control in Type 2 Diabetic Patients. Acta Med Scand 1986; 220(3): 219-224.
41. Mikus CR, Oberlin DJ, Libla JL, Taylor AM, Booth FW, Thyfault JP. Lowering physical activity impairs glycemic control in healthy volunteers. Med Sci Sports Exerc 2012; 44(2): 225-231.
42. Bonora E, Calcaterra F, Lombardi S, et al. Plasma glucose levels throughout the day and HbA1c interrelationships in type 2 diabetes. Diabetes Care 2001; 24(12): 2023-2029.
43. Woerle HJ, Neumann C, Zschau S, et al. Impact of fasting and postprandial glycemia on overall glycemic control in type 2 diabetes Importance of postprandial glycemia to achieve target HbA1c levels. Diabetes Res Clin Pract 2007; 77(2): 280.
44. Monnier L, Colette C, Boniface H. Contribution of postprandial glucose to chronic hyperglycaemia: from the "glucose triad" to the trilogy of "sevens". Diabetes Metab 2006; 32(S2): 11-16.
45. Brownlee M, Hirsch IB. Glycemic variability: a hemoglobin A1c-independent risk factor for diabetic complications. JAMA 2006; 295(14): 1707-1708.
46. Rosenthal R, DiMatteo MR. Meta-analysis: Recent developments in quantitative methods for literature reviews. Annu Rev Psychol 2001; 52(1): 59-82.
47. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009; 339: b2535.