Glycaemic control is improved by 7 days of aerobic exercise training in patients with type 2 diabetes

Diabetologia

Volumn 55, Issue 5, 2012, Pages 1417-1423

  Mikus, C R ^a   Oberlin, D J ^a   Libla, J ^a   Boyle, L J ^a   Thyfault, J P ^a  

^a University of Missouri   (United States)

Author keywords

Glycaemic control; Physical activity; Postprandial glycaemia; Type 2 diabetes mellitus

Indexed keywords

C PEPTIDE; GLUCOSE; HEMOGLOBIN A1C; INSULIN;

ADULT; AEROBIC EXERCISE; AGED; ARTICLE; BLOOD GLUCOSE MONITORING; BODY COMPOSITION; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY BALANCE; ENERGY EXPENDITURE; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HABITUAL ADAPTATION; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHYSICAL ACTIVITY; POSTPRANDIAL STATE; PRIORITY JOURNAL;

ADIPOSITY; BLOOD GLUCOSE; BODY MASS INDEX; C-PEPTIDE; DIABETES MELLITUS, TYPE 2; DIET; EXERCISE; EXERCISE THERAPY; FEMALE; GLUCOSE TOLERANCE TEST; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN; MALE; MIDDLE AGED; POSTPRANDIAL PERIOD;

EID: 84862572402     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2490-8     Document Type: Article

References (43)

1. Stratton IM, Adler AI, Neil HA et al (2000) Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 321: 405-412
2. The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulindependent diabetes mellitus. N Engl J Med 329: 977-986
3. Association AD (2010) Standards of medical care in diabetes- 2010. Diabetes Care 33(Suppl 1): S11-S61
4. Gerstein HC, Miller ME, Byington RP et al (2008) Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 358: 2545-2559
5. Patel A, MacMahon S, Chalmers J et al (2008) Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 358: 2560-2572
6. Duckworth W, Abraira C, Moritz T et al (2009) Glucose control and vascular complications in veterans with type 2 diabetes. NEngl J Med 360: 129-139
7. Skyler JS, Bergenstal R, Bonow RO et al (2009) Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA diabetes trials: aposition statement of the American Diabetes Association and ascientific statement of the American College of Cardiology Foundation and the American Heart Association. Diabetes Care 32: 187-192
8. Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M et al (2011) Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ 343: d4169
9. Sacks DB, Bruns DE, Goldstein DE, Maclaren NK, McDonald JM, Parrott M (2002) Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem 48: 436-472
10. Dandona P, Chaudhuri A, Dhindsa S (2010) Proinflammatory and prothrombotic effects of hypoglycemia. Diabetes Care 33: 1686-1687
11. Wright E Jr, Scism-Bacon JL, Glass LC (2006) Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia. Int J Clin Pract 60: 308-314
12. Temelkova-Kurktschiev TS, Koehler C, Henkel E, Leonhardt W, Fuecker K, Hanefeld M (2000) Postchallenge plasma glucose and glycemic spikes are more strongly associated with atherosclerosis than fasting glucose or HbA1c level. Diabetes Care 23: 1830-1834
13. Cederberg H, Saukkonen T, Laakso M et al (2010) Postchallenge glucose, HbA1c, and fasting glucose as predictors of type 2 diabetes and cardiovascular disease: a 10-year prospective cohort study. Diabetes Care 33: 2077-2083
14. Levitan EB, Song Y, Ford ES, Liu S (2004) Is nondiabetic hyperglycemia a risk factor for cardiovascular disease? A meta-analysis of prospective studies. Arch Intern Med 164: 2147-2155
15. Saydah SH, Miret M, Sung J, Varas C, Gause D, Brancati FL (2001) Postchallenge hyperglycemia and mortality in a national sample of U.S. adults. Diabetes Care 24: 1397-1402
16. Cavalot F, Pagliarino A, Valle M et al (2011) Postprandial blood glucose predicts cardiovascular events and all-cause mortality in type 2 diabetes in a 14-year follow-up: lessons from the San Luigi Gonzaga Diabetes Study. Diabetes Care 34: 2237-2243
17. Knowler WC, Barrett-Connor E, Fowler SE et al (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346: 393-403
18. Colberg SR, Sigal RJ, Fernhall B et al (2010) Exercise and type 2 diabetes: theAmerican College of SportsMedicine and theAmerican Diabetes Association: joint position statement. Diabetes Care 33: e147-e167
19. Umpierre D, Ribeiro PA, Kramer CK et al (2011) Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: a systematic review and metaanalysis. JAMA: J Am Med Assoc 305: 1790-1799
20. Church TS, Blair SN, Cocreham S et al (2010) Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial. JAMA: J Am Med Assoc 304: 2253-2262
21. Bassuk SS, Manson JE (2005) Epidemiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease. J Appl Physiol 99: 1193-1204
22. Heath GW, Gavin JR 3rd, Hinderliter JM, Hagberg JM, Bloomfield SA, Holloszy JO (1983) Effects of exercise and lack of exercise on glucose tolerance and insulin sensitivity. J Appl Physiol 55: 512-517
23. Kirwan JP, Solomon TP, Wojta DM, Staten MA, Holloszy JO (2009) Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 297: E151-E156
24. Rogers MA, Yamamoto C, King DS, Hagberg JM, Ehsani AA, Holloszy JO (1988) Improvement in glucose tolerance after 1 wk of exercise in patients with mild NIDDM. Diabetes Care 11: 613-618
25. Winnick JJ, Sherman WM, Habash DL et al (2008) Short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole-body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivity. J Clin Endocrinol Metab 93: 771-778
26. Kang J, Robertson RJ, Hagberg JM et al (1996) Effect of exercise intensity on glucose and insulin metabolism in obese individuals and obese NIDDM patients. Diabetes Care 19: 341-349
27. Mikus CR, Fairfax ST, Libla JL et al (2011) Seven days of aerobic exercise training improves conduit artery blood flow following glucose ingestion in patients with type 2 diabetes. J Appl Physiol 111: 657-664
28. Karvonen J, Vuorimaa T (1988) Heart rate and exercise intensity during sports activities. Practical application. Sports Med 5: 303-311
29. American College of Sports Medicine (2010) ACSM's guidelines for exercise testing and prescription, 8th edn. Lippincott Williams and Wilkins, Philadelphia, PA
30. Mikus CR, Oberlin DJ, Libla JL, Taylor AM, Booth FW, Thyfault JP (2012) Lowering physical activity impairs glycemic control in healthy volunteers. Med Sci Sports Exerc 44: 225-231
31. Angelopoulos TJ, Schultz RM, Denton JC, Jamurtas AZ (2002) Significant enhancements in glucose tolerance and insulin action in centrally obese subjects following ten days of training. Clin J Sport Med 12: 113-118
32. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419
33. Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22: 1462-1470
34. Hasson RE, Freedson PS, Braun B (2010) Use of continuous glucose monitoring in normoglycemic, insulin-resistant women. Eur J Appl Physiol Occup Physiol 108: 1181-1187
35. Avignon A, Radauceanu A, Monnier L (1997) Nonfasting plasma glucose is a better marker of diabetic control than fasting plasma glucose in type 2 diabetes. Diabetes Care 20: 1822-1826
36. Cavalot F, Petrelli A, Traversa M et al (2006) Postprandial blood glucose is a stronger predictor of cardiovascular events than fasting blood glucose in type 2 diabetes mellitus, particularly in women: lessons from the San Luigi Gonzaga Diabetes Study. J Clin Endocrinol Metab 91: 813-819
37. Bonora E, Muggeo M (2001) Postprandial blood glucose as a risk factor for cardiovascular disease in type II diabetes: the epidemiological evidence. Diabetologia 44: 2107-2114
38. Boyne MS, Silver DM, Kaplan J, Saudek CD (2003) Timing of changes in interstitial and venous blood glucose measured with a continuous subcutaneous glucose sensor. Diabetes 52: 2790-2794
39. Steil GM, Rebrin K, Mastrototaro J, Bernaba B, Saad MF (2003) Determination of plasma glucose during rapid glucose excursions with a subcutaneous glucose sensor. Diabetes Technol Ther 5: 27-31
40. Weinstein RL, Schwartz SL, Brazg RL, Bugler JR, Peyser TA, McGarraugh GV (2007) Accuracy of the 5-day FreeStyle Navigator Continuous Glucose Monitoring System: comparison with frequent laboratory reference measurements. Diabetes Care 30: 1125-1130
41. Buckingham BA, Kollman C, Beck R et al (2006) Evaluation of factors affecting CGMS calibration. Diabetes Technol Ther 8: 318-325
42. Wallace AJ, Willis JA, Monro JA, Frampton CM, Hedderley DI, Scott RS (2006) No difference between venous and capillary blood sampling and the Minimed continuous glucose monitoring system for determining the blood glucose response to food. Nutr Res (New York, NY) 26: 403-408
43. Hay LC, Wilmshurst EG, Fulcher G (2003) Unrecognized hypoand hyperglycemia in well-controlled patients with type 2 diabetes mellitus: the results of continuous glucose monitoring. Diabetes Technol Ther 5: 19-26