Evaluation of antiviral activities of four local Malaysian phyllanthus species against herpes simplex viruses and possible antiviral target

International Journal of Medical Sciences

Volumn 10, Issue 13, 2013, Pages 1817-1829

  Tan, Wee Chee ^a   Jaganath, Indu Bala ^b   Manikam, Rishya ^c   Sekaran, Shamala Devi ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b MALAYSIAN AGRICULTURAL RESEARCH AND DEVELOPMENT INSTITUTE MARDI   (Malaysia)

^c UNIVERSITY MALAYA MEDICAL CENTRE   (Malaysia)

Author keywords

Antiviral; Cytoskeleton; Herpes simplex virus; Phyllanthus

Indexed keywords

ANTIVIRUS AGENT; CELL PROTEIN; PHYLLANTHUS AMARUS EXTRACT; PHYLLANTHUS NIRURI EXTRACT; PHYLLANTHUS URINARIA EXTRACT; PHYLLANTHUS WATSONII EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG TARGETING; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; NONHUMAN; PHYLLANTHUS; PHYLLANTHUS URINARIA; PHYLLANTHUS WATSONII; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; TWO DIMENSIONAL GEL ELECTROPHORESIS; VERO CELL LINE; VIRUS INFECTION; VIRUS REPLICATION; WESTERN BLOTTING;

ANTIVIRAL; CYTOSKELETON.; HERPES SIMPLEX VIRUS; PHYLLANTHUS;

ANIMALS; ANTIVIRAL AGENTS; BASE SEQUENCE; BLOTTING, WESTERN; CERCOPITHECUS AETHIOPS; DNA PRIMERS; DRUG EVALUATION, PRECLINICAL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; MALAYSIA; MICROBIAL SENSITIVITY TESTS; PHYLLANTHUS; PLANT EXTRACTS; REAL-TIME POLYMERASE CHAIN REACTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; VERO CELLS; VIRAL PLAQUE ASSAY;

EID: 84887711117     PISSN: 14491907     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijms.6902     Document Type: Article

References (38)

1. Roizman B, Knipe DM, Whitley RJ. Herpes Simplex Viruses. In: Knipe DM, Howley PM, editors. Fields Virology, 5th edition. Philadelphia: Lippincott Williams & Wilkins; 2006;: 2501-2601.
2. Fatahzadeh M, Schwartz RA. Human herpes simplex infections: Epidemiology, pathogenesis, symptomatology, diagnosis, and management. Journal of the American Academy of Dermatology. 2007; 57: 737-763.
3. Whitley RJ, Roizman B. Herpes simplex virus infections. The Lancet. 2001; 357: 1513-1518.
4. Looker KJ, Garnett GP, Schmid GP. An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. Bulletin of the World Health Organization. 2008; 86: 805-12A.
5. Celum C, Wald A, Lingappa JR, Magaret AS, Wang RS, Mugo N. Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2. New England Journal of Medicine. 2010; 362: 427-439.
6. Corey L. Synergistic Copathogens- HIV-1 and HSV-2. New England Journal of Medicine. 2007; 356: 854-856.
7. Morfin F, Thouvenot D. Herpes simplex virus resistance to antiviral drugs. Journal of Clinical Virology. 2003; 26: 29-37.
8. Bacon TH, Levin MJ, Leary JJ, Sarisky RT, Sutton D. Herpes Simplex Virus Resistance to Acyclovir and Penciclovir after Two Decades of Antiviral Therapy. Clinical Microbiology Reviews. 2003; 16: 114-128.
9. Piret J, Boivin G. Resistance of Herpes Simplex Viruses to Nucleoside Analogues: Mechanisms, Prevalence, and Management. Antimicrobial Agents and Chemotherapy. 2011; 55: 459-472.
10. Vilhelmova N, Jacquet R, Quideau S, Stoyanova A, Galabov AS. Three-dimensional analysis of combination effect of ellagitannins and acyclovir on herpes simplex virus type 1 and 2. Antiviral research. 2011; 89: 174-181.
11. Xiong HR, Luo J, Hou W, Xiao H, Yang ZQ. The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, agaist herpes simplex virus in vitro and in vivo. Journal of Ethnopharmacology. 2011; 133: 718-723.
12. Chen X, Qiao H, Liu T, Yang Z, Xu L, Xu Y, et al. Inhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation. Antiviral Research. 2012; 95: 30-36.
13. Mukhtar M, Arshad M, Ahmad M, Pomerantz RJ, Wigdahl B, Parveen Z. Antiviral potentials of medicinal plants. Virus Research. 2008; 131: 111-120.
14. Joseph B, Raj SJ. An Overview: Pharmacognostic Properties of Phyllanthus amarus Linn. International Journal of Pharmacology. 2011; 7: 40-45.
15. Calixto JB, Santos ARS, Filho VC, Yunes RA. A review of the plants of the genus Phyllanthus: Their chemistry, pharmacology, and therapeutic potential. Medical Research Reviews. 1998; 18: 225-258.
16. Unander DW, Webster GL, Blumberg BS. Usage and bioassays in Phyllanthus (Euphorbiaceae). IV. Clustering of antiviral uses and other effects. Journal of Ethnopharmacology. 1995; 45: 1-18.
17. Venkateswaran PS, Millman I, Blumberg BS. Effects of an extract from Phyllanthus niruri on hepatitis B and woodchuck hepatitis viruses: in vitro and in vivo. Proceedings of the National Academy of Sciences. 1987; 84: 274-278.
18. Xiang YF, Pei Y, Wang YF. Current status of natural products from plants as anti-herpes simplex virus 1 agents. Virologica Sinica. 2008; 23: 305-314.
19. Khan MTH, Ather A, Thompson KD, Gambari R. Extracts and molecules from medicinal plants against herpes simplex viruses. Antiviral Research. 2005; 67: 107-119.
20. Álvarez ÁL, Dalton KP, Nicieza I, Diñeiro Y, Picinelli A, Melón S, et al. Bioactivity-guided Fractionation of Phyllanthus orbicularis and Identification of the Principal Anti HSV-2 Compounds. Phytotherapy Research. 2012; 26: 1513-1520.
21. Tang YQ, Jaganath IB, Sekaran SD. Phyllanthus spp. Induces Selective Growth Inhibition of PC-3 and MeWo Human Cancer Cells through Modulation of Cell Cycle and Induction of Apoptosis. PLoS ONE. 2010; 5: e12644.
22. Lee SH, Jaganath IB, Wang SM, Sekaran SD. Antimetastatic Effects of Phyllanthus on Human Lung (A549) and Breast (MCF-7) Cancer Cell. PLoS ONE. 2011; 6: e20994.
23. Rajeshkumar NV, Kuttan R. Phyllanthus amarus extract administration increases the life span of rats with hepatocellular carcinoma. Journal of Ethnopharmacology. 2000; 73: 215-219.
24. Khanna AK, Rizvi F, Chander R. Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats. Journal of Ethnopharmacology. 2002; 82: 19-22.
25. Ali H, Houghton PJ, Soumyanath A. α-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. Journal of Ethnopharmacology. 2006; 107: 449-455.
26. Yang C-M, Cheng HY, Lin T-C, Chiang LC, Lin CC. Acetone, ethanol and methanol extracts of Phyllanthus urinaria inhibit HSV-2 infection in vitro. Antiviral Research. 2005; 67: 24-30.
27. Yang CM, Cheng HY, Lin TC, Chiang LC, Lin CC. The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-β-d-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection. Journal of Ethnopharmacology. 2007; 110: 555-558.
28. Chattopadhyay D, Chawla-Sarkar M, Chatterjee T, Dey RS, Bag P, Chakraborti S, et al. Recent advancements for the evaluation of anti-viral activities of natural products. New Biotechnology. 2009; 25: 347-368.
29. Cheng HY, Yang CM, Lin TC, Chiang LC, Lin CC. Excoecarianin, Isolated from Phyllanthus urinaria Linnea, Inhibits Herpes Simplex Virus Type 2 Infection through Inactivation of Viral Particles. Evidence-Based Complementary and Alternative Medicine. 2011;:259103.
30. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proceedings of the National Academy of Sciences. 1979; 76: 4350-4354.
31. Zhong MG, Xiang YF, Qiu XX, Liu Z, Kitazato K, Wang YF. Natural products as a source of anti-herpes simplex virus agents. RSC Advances. 2012. doi:10.1039/c2ra21464d.
32. Naithani R, Huma LC, Holland LE, Louis EH, Shukla D, McCormick DL, et al. Antiviral Activity of Phytochemicals: A Comprehensive Review. Mini Reviews in Medicinal Chemistry. 2008; 8: 1106-1133.
33. Antrobus R, Grant K, Gangadharan B, Chittenden D, Everett RD, Zitzmann N, et al. Proteomic analysis of cells in the early stages of herpes simplex virus type-1 infection reveals widespread changes in the host cell proteome. Proteomics. 2009; 9: 3913-3927.
34. Oikonomou KG, Zachou K, Dalekos GN. Alpha-actinin: A multidisciplinary protein with important role in B-cell driven autoimmunity. Autoimmunity Reviews. 2011; 10: 389-96.
35. Lan S, Wang H, Jiang H, Mao H, Liu X, Zhang X, et al. Direct interaction between α-actinin and hepatitis C virus NS5B. FESB Letters. 2003; 554: 289-294.
36. Otey CA, Carpen O. α-actinin revisited: A fresh look at an old player. Cell Motility and the Cytoskeleton. 2004; 58: 104-111.
37. Abrantes JL, Alves CM, Costa J, Almeida FCL, Sola-Penna M, Fontes CFL, et al. Herpes simplex type 1 activates glycolysis through engagement of the enzyme 6-phosphofructo-1-kinase (PFK-1). Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2012; 1822: 1198-1206.
38. Jamaluddin M, Wiktorowicz JE, Soman KV, Boldogh I, Forbus JD, Spratt H, et al. Role of Peroxiredoxin 1 and Peroxiredoxin 4 in Protection of Respiratory Syncytial Virus-Induced Cysteinyl Oxidation of Nuclear Cytoskeletal Proteins. Journal of Virology. 2010; 84: 9533-9545.