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Volumn 25, Issue 6, 2013, Pages 206-211

Panax notoginseng saponins improve the erectile dysfunction in diabetic rats by protecting the endothelial function of the penile corpus cavernosum

Author keywords

Corpus cavernosum endothelium; Diabetes mellitus; ED; Endothelial nitric oxide synthase; NO

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CYCLIC GMP; DNA NUCLEOTIDYLEXOTRANSFERASE; GLUCOSE; NITRIC OXIDE SYNTHASE; SAPONIN DERIVATIVE;

EID: 84887626013     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/ijir.2013.19     Document Type: Article
Times cited : (25)

References (42)
  • 1
    • 0038487156 scopus 로고    scopus 로고
    • Optimizing treatment for diabetes mellitus induced erectile dysfunction
    • discussion S39
    • Costabile RA. Optimizing treatment for diabetes mellitus induced erectile dysfunction. J Urol 2003; 170: S35-S38, discussion S39.
    • (2003) J Urol , vol.170
    • Costabile, R.A.1
  • 3
    • 0035670773 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase protein expression, localization, and activity in the penis of the alloxan-induced diabetic rat
    • Akingba AG, Burnett AL. Endothelial nitric oxide synthase protein expression, localization, and activity in the penis of the alloxan-induced diabetic rat. Mol Urol 2001; 5: 189-197.
    • (2001) Mol Urol , vol.5 , pp. 189-197
    • Akingba, A.G.1    Burnett, A.L.2
  • 4
    • 0035075785 scopus 로고    scopus 로고
    • Advanced glycation end-products are responsible for the impairment of corpus cavernosal smooth muscle relaxation seen in diabetes
    • Cartledge JJ, Eardley I, Morrison JF. Advanced glycation end-products are responsible for the impairment of corpus cavernosal smooth muscle relaxation seen in diabetes. BJU Int 2001; 87: 402-407.
    • (2001) BJU Int , vol.87 , pp. 402-407
    • Cartledge, J.J.1    Eardley, I.2    Morrison, J.F.3
  • 5
    • 24044534162 scopus 로고    scopus 로고
    • Erectile dysfunction in diabetic patients
    • Chaiban JT, Azar ST. Erectile dysfunction in diabetic patients. J Med Liban 2004; 52: 217-219.
    • (2004) J Med Liban , vol.52 , pp. 217-219
    • Chaiban, J.T.1    Azar, S.T.2
  • 6
    • 0036755003 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction
    • Corbin JD, Francis SH, Webb DJ. Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction. Urology 2002; 60: 4-11.
    • (2002) Urology , vol.60 , pp. 4-11
    • Corbin, J.D.1    Francis, S.H.2    Webb, D.J.3
  • 7
    • 19744364991 scopus 로고    scopus 로고
    • Enhancement of both EDHF and NO/cGMP pathways is necessary to reverse erectile dysfunction in diabetic rats
    • Angulo J, Cuevas P, Gabancho S, Gonzalez-Corrochano R, Videla S, Saenz de Tejada I. Enhancement of both EDHF and NO/cGMP pathways is necessary to reverse erectile dysfunction in diabetic rats. J Sex Med 2005; 2: 341-346.
    • (2005) J Sex Med , vol.2 , pp. 341-346
    • Angulo, J.1    Cuevas, P.2    Gabancho, S.3    Gonzalez-Corrochano, R.4    Videla, S.5    Saenz De Tejada, I.6
  • 8
    • 33845332378 scopus 로고    scopus 로고
    • Pathophysiology and treatment of diabetic erectile dysfunction
    • Moore CR, Wang R. Pathophysiology and treatment of diabetic erectile dysfunction. Asian J Androl 2006; 8: 675-684.
    • (2006) Asian J Androl , vol.8 , pp. 675-684
    • Moore, C.R.1    Wang, R.2
  • 9
    • 33745889215 scopus 로고    scopus 로고
    • Phytochemical and analytical studies of Panax notoginseng (Burk.) FH Chen
    • Wang CZ, McEntee E, Wicks S, Wu JA, Yuan CS. Phytochemical and analytical studies of Panax notoginseng (Burk.) FH Chen. J Nat Med 2006; 60: 97-106.
    • (2006) J Nat Med , vol.60 , pp. 97-106
    • Wang, C.Z.1    McEntee, E.2    Wicks, S.3    Wu, J.A.4    Yuan, C.S.5
  • 10
    • 4544369555 scopus 로고    scopus 로고
    • Total saponins of Panax notoginseng protected rabbit iliac artery against balloon endothelial denudation injury
    • Chen SW, Li XH, Ye KH, Jiang ZF, Ren XD. Total saponins of Panax notoginseng protected rabbit iliac artery against balloon endothelial denudation injury. Acta Pharmacol Sin 2004; 25: 1151-1156.
    • (2004) Acta Pharmacol Sin , vol.25 , pp. 1151-1156
    • Chen, S.W.1    Li, X.H.2    Ye, K.H.3    Jiang, Z.F.4    Ren, X.D.5
  • 11
    • 65649110072 scopus 로고    scopus 로고
    • Angiogenic effect of saponin extract from Panax notoginseng on HUVECs in vitro and zebrafish in vivo
    • Hong SJ, Wan JB, Zhang Y, Hu G, Lin HC, Seto SW et al. Angiogenic effect of saponin extract from Panax notoginseng on HUVECs in vitro and zebrafish in vivo. Phytother Res 2009; 23: 677-686.
    • (2009) Phytother Res , vol.23 , pp. 677-686
    • Hong, S.J.1    Wan, J.B.2    Zhang, Y.3    Hu, G.4    Lin, H.C.5    Seto, S.W.6
  • 12
    • 75449116364 scopus 로고    scopus 로고
    • Effect of total saponins of "panax notoginseng root" on aortic intimal hyperplasia and the expressions of cell cycle protein and extracellular matrix in rats
    • Wu L, Zhang W, Tang YH, Li H, Chen BY, Zhang GM et al. Effect of total saponins of "panax notoginseng root" on aortic intimal hyperplasia and the expressions of cell cycle protein and extracellular matrix in rats. Phytomedicine 2010; 17: 233-240.
    • (2010) Phytomedicine , vol.17 , pp. 233-240
    • Wu, L.1    Zhang, W.2    Tang, Y.H.3    Li, H.4    Chen, B.Y.5    Zhang, G.M.6
  • 13
    • 34547405823 scopus 로고    scopus 로고
    • Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide- induced microcirculatory disturbance in rat mesentery
    • Sun K, Wang CS, Guo J, Horie Y, Fang SP, Wang F et al. Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide- induced microcirculatory disturbance in rat mesentery. Life Sci 2007; 81: 509-518.
    • (2007) Life Sci , vol.81 , pp. 509-518
    • Sun, K.1    Wang, C.S.2    Guo, J.3    Horie, Y.4    Fang, S.P.5    Wang, F.6
  • 14
    • 33748690115 scopus 로고    scopus 로고
    • Ginsenoside-Rd from panax notoginseng blocks Ca2O influx through receptor- and store-operated Ca2O channels in vascular smooth muscle cells
    • Guan YY, Zhou JG, Zhang Z, Wang GL, Cai BX, Hong L et al. Ginsenoside-Rd from panax notoginseng blocks Ca2O influx through receptor- and store-operated Ca2O channels in vascular smooth muscle cells. Eur J Pharmacol 2006; 548: 129-136.
    • (2006) Eur J Pharmacol , vol.548 , pp. 129-136
    • Guan, Y.Y.1    Zhou, J.G.2    Zhang, Z.3    Wang, G.L.4    Cai, B.X.5    Hong, L.6
  • 15
    • 0034531895 scopus 로고    scopus 로고
    • Effects of Panax notoginseng saponins on vascular endothelial cells in vitro
    • Kwan CY, Kwan TK. Effects of Panax notoginseng saponins on vascular endothelial cells in vitro. Acta Pharmacol Sin 2000; 21: 1101-1105.
    • (2000) Acta Pharmacol Sin , vol.21 , pp. 1101-1105
    • Kwan, C.Y.1    Kwan, T.K.2
  • 16
    • 77954956789 scopus 로고    scopus 로고
    • Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components
    • Yang CY, Wang J, Zhao Y, Shen L, Jiang X, Xie ZG et al. Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components. J Ethnopharmacol 2010; 130: 231-236.
    • (2010) J Ethnopharmacol , vol.130 , pp. 231-236
    • Yang, C.Y.1    Wang, J.2    Zhao, Y.3    Shen, L.4    Jiang, X.5    Xie, Z.G.6
  • 17
    • 31744431907 scopus 로고    scopus 로고
    • Vascular endothelial growth factor restores erectile function through modulation of the insulin-like growth factor system and sex hormone receptors in diabetic rat
    • Shirai M, Yamanaka M, Shiina H, Igawa M, Kawakami T, Ishii N et al. Vascular endothelial growth factor restores erectile function through modulation of the insulin-like growth factor system and sex hormone receptors in diabetic rat. Biochem Biophys Res Commun 2006; 341: 755-762.
    • (2006) Biochem Biophys Res Commun , vol.341 , pp. 755-762
    • Shirai, M.1    Yamanaka, M.2    Shiina, H.3    Igawa, M.4    Kawakami, T.5    Ishii, N.6
  • 18
    • 10344242040 scopus 로고    scopus 로고
    • Vascular endothelial growth factor restores erectile function through inhibition of apoptosis in diabetic rat penile crura
    • Yamanaka M, Shirai M, Shiina H, Tanaka Y, Enokida H, Tsujimura A et al. Vascular endothelial growth factor restores erectile function through inhibition of apoptosis in diabetic rat penile crura. J Urol 2005; 173: 318-323.
    • (2005) J Urol , vol.173 , pp. 318-323
    • Yamanaka, M.1    Shirai, M.2    Shiina, H.3    Tanaka, Y.4    Enokida, H.5    Tsujimura, A.6
  • 19
    • 62549108148 scopus 로고    scopus 로고
    • Loss of surface N-methyl-Daspartate receptor proteins in mouse cortical neurones during anaesthesia induced by chloral hydrate in vivo
    • LacKamp A, Zhang GC, Mao LM, Fibuch EE, Wang JQ. Loss of surface N-methyl-Daspartate receptor proteins in mouse cortical neurones during anaesthesia induced by chloral hydrate in vivo. Br J Anaesth 2009; 102: 515-522.
    • (2009) Br J Anaesth , vol.102 , pp. 515-522
    • Lackamp, A.1    Zhang, G.C.2    Mao, L.M.3    Fibuch, E.E.4    Wang, J.Q.5
  • 20
    • 77954512966 scopus 로고    scopus 로고
    • Effects of buried penis on the structure and function of corpus cavernosum in a rat model
    • Cheng F, Yu WM, Xia Y, Zhang XB, Yang SX, Ge MH. Effects of buried penis on the structure and function of corpus cavernosum in a rat model. Chin Med J (Engl) 2010; 123: 1736-1740.
    • (2010) Chin Med J (Engl) , vol.123 , pp. 1736-1740
    • Cheng, F.1    Yu, W.M.2    Xia, Y.3    Zhang, X.B.4    Yang, S.X.5    Ge, M.H.6
  • 21
    • 84863232936 scopus 로고    scopus 로고
    • Yidiyin, a Chinese herbal decoction, improves erectile dysfunction in diabetic patients and rats through the NO-cGMP pathway
    • Feng XT, Qin CB, Leng J, Tang QL, Shi H, Zhai LN et al. Yidiyin, a Chinese herbal decoction, improves erectile dysfunction in diabetic patients and rats through the NO-cGMP pathway. Biosci Biotechnol Biochem 2012; 76: 257-263.
    • (2012) Biosci Biotechnol Biochem , vol.76 , pp. 257-263
    • Feng, X.T.1    Qin, C.B.2    Leng, J.3    Tang, Q.L.4    Shi, H.5    Zhai, L.N.6
  • 23
    • 33847372051 scopus 로고    scopus 로고
    • Endothelial dysfunction in diabetic erectile dysfunction
    • Musicki B, Burnett AL. Endothelial dysfunction in diabetic erectile dysfunction. Int J Impot Res 2007; 19: 129-138.
    • (2007) Int J Impot Res , vol.19 , pp. 129-138
    • Musicki, B.1    Burnett, A.L.2
  • 24
    • 0026625948 scopus 로고
    • Hypertension, the endothelial cell, and the vascular complications of diabetes mellitus
    • Hsueh WA, Anderson PW. Hypertension, the endothelial cell, and the vascular complications of diabetes mellitus. Hypertension 1992; 20: 253-263.
    • (1992) Hypertension , vol.20 , pp. 253-263
    • Hsueh, W.A.1    Anderson, P.W.2
  • 25
    • 0033023938 scopus 로고    scopus 로고
    • Intracavernous pressure during erection in rats: An integrative approach based on telemetric recording
    • Bernabe J, Rampin O, Sachs BD, Giuliano F. Intracavernous pressure during erection in rats: an integrative approach based on telemetric recording. Am J Physiol 1999; 276: R441-R449.
    • (1999) Am J Physiol , vol.276
    • Bernabe, J.1    Rampin, O.2    Sachs, B.D.3    Giuliano, F.4
  • 26
    • 0029965790 scopus 로고    scopus 로고
    • The rabbit as an intracavernous injection study model
    • Lin YM, Lin JS. The rabbit as an intracavernous injection study model. Urol Res 1996; 24: 27-32.
    • (1996) Urol Res , vol.24 , pp. 27-32
    • Lin, Y.M.1    Lin, J.S.2
  • 27
    • 78650690458 scopus 로고    scopus 로고
    • Pentoxifylline promotes recovery of erectile function in a rat model of postprostatectomy erectile dysfunction
    • Albersen M, Fandel TM, Zhang H, Banie L, Lin G, De Ridder D et al. Pentoxifylline promotes recovery of erectile function in a rat model of postprostatectomy erectile dysfunction. Eur Urol 2011; 59: 286-296.
    • (2011) Eur Urol , vol.59 , pp. 286-296
    • Albersen, M.1    Fandel, T.M.2    Zhang, H.3    Banie, L.4    Lin, G.5    De Ridder, D.6
  • 28
    • 52949116001 scopus 로고    scopus 로고
    • Effect of caffeine on erectile function via up-regulating cavernous cyclic guanosine monophosphate in diabetic rats
    • Yang R, Wang J, Chen Y, Sun Z, Wang R, Dai Y. Effect of caffeine on erectile function via up-regulating cavernous cyclic guanosine monophosphate in diabetic rats. J Androl 2008; 29: 586-591.
    • (2008) J Androl , vol.29 , pp. 586-591
    • Yang, R.1    Wang, J.2    Chen, Y.3    Sun, Z.4    Wang, R.5    Dai, Y.6
  • 29
    • 77955242336 scopus 로고    scopus 로고
    • The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemiaassociated erectile dysfunction in a rat model
    • Huang YC, Ning H, Shindel AW, Fandel TM, Lin G, Harraz AM et al. The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemiaassociated erectile dysfunction in a rat model. J Sex Med 2010; 7: 1391-1400.
    • (2010) J Sex Med , vol.7 , pp. 1391-1400
    • Huang, Y.C.1    Ning, H.2    Shindel, A.W.3    Fandel, T.M.4    Lin, G.5    Harraz, A.M.6
  • 30
    • 67649850654 scopus 로고    scopus 로고
    • Metrics for evaluation of age-related changes in erectile capacity in a rodent model
    • Zhao W, Sato Y, Melman A, Andersson KE, Christ G. Metrics for evaluation of age-related changes in erectile capacity in a rodent model. J Sex Med 2009; 6: 1885-1892.
    • (2009) J Sex Med , vol.6 , pp. 1885-1892
    • Zhao, W.1    Sato, Y.2    Melman, A.3    Andersson, K.E.4    Christ, G.5
  • 31
    • 75649113803 scopus 로고    scopus 로고
    • Diabetes exacerbates the functional deficiency of NO/cGMP pathway associated with erectile dysfunction in human corpus cavernosum and penile arteries
    • Angulo J, Gonzalez-Corrochano R, Cuevas P, Fernandez A, La Fuente JM, Rolo F et al. Diabetes exacerbates the functional deficiency of NO/cGMP pathway associated with erectile dysfunction in human corpus cavernosum and penile arteries. J Sex Med 2010; 7: 758-768.
    • (2010) J Sex Med , vol.7 , pp. 758-768
    • Angulo, J.1    Gonzalez-Corrochano, R.2    Cuevas, P.3    Fernandez, A.4    La Fuente, J.M.5    Rolo, F.6
  • 32
    • 0035073019 scopus 로고    scopus 로고
    • Nitric oxide-mediated corpus cavernosal smooth muscle relaxation is impaired in ageing and diabetes
    • Cartledge JJ, Eardley I, Morrison JF. Nitric oxide-mediated corpus cavernosal smooth muscle relaxation is impaired in ageing and diabetes. BJU Int 2001; 87: 394-401.
    • (2001) BJU Int , vol.87 , pp. 394-401
    • Cartledge, J.J.1    Eardley, I.2    Morrison, J.F.3
  • 33
    • 33646556664 scopus 로고    scopus 로고
    • Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells
    • Leung KW, Cheng YK, Mak NK, Chan KK, Fan TP, Wong RN. Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells. FEBS Lett 2006; 580: 3211-3216.
    • (2006) FEBS Lett , vol.580 , pp. 3211-3216
    • Leung, K.W.1    Cheng, Y.K.2    Mak, N.K.3    Chan, K.K.4    Fan, T.P.5    Wong, R.N.6
  • 34
    • 70349813767 scopus 로고    scopus 로고
    • Role of microRNA-214 in ginsenoside-Rg1- induced angiogenesis
    • Chan LS, Yue PY, Mak NK, Wong RN. Role of microRNA-214 in ginsenoside-Rg1- induced angiogenesis. Eur J Pharm Sci 2009; 38: 370-377.
    • (2009) Eur J Pharm Sci , vol.38 , pp. 370-377
    • Chan, L.S.1    Yue, P.Y.2    Mak, N.K.3    Wong, R.N.4
  • 35
    • 3242678853 scopus 로고    scopus 로고
    • Ginsenoside Rg1-induced alterations in gene expression in TNF-alpha stimulated endothelial cells
    • Lu JP, Ma ZC, Yang J, Huang J, Wang SR, Wang SQ. Ginsenoside Rg1-induced alterations in gene expression in TNF-alpha stimulated endothelial cells. Chin Med J (Engl) 2004; 117: 871-876.
    • (2004) Chin Med J (Engl) , vol.117 , pp. 871-876
    • Lu, J.P.1    Ma, Z.C.2    Yang, J.3    Huang, J.4    Wang, S.R.5    Wang, S.Q.6
  • 36
    • 0031451658 scopus 로고    scopus 로고
    • Advanced glycation end products in human penis: Elevation in diabetic tissue, site of deposition, and possible effect through iNOS or eNOS
    • Seftel AD, Vaziri ND, Ni Z, Razmjouei K, Fogarty J, Hampel N et al. Advanced glycation end products in human penis: elevation in diabetic tissue, site of deposition, and possible effect through iNOS or eNOS. Urology 1997; 50: 1016-1026.
    • (1997) Urology , vol.50 , pp. 1016-1026
    • Seftel, A.D.1    Vaziri, N.D.2    Ni, Z.3    Razmjouei, K.4    Fogarty, J.5    Hampel, N.6
  • 37
    • 0035135246 scopus 로고    scopus 로고
    • Advanced glycation end-products: A review
    • Singh R, Barden A, Mori T, Beilin L. Advanced glycation end-products: a review. Diabetologia 2001; 44: 129-146.
    • (2001) Diabetologia , vol.44 , pp. 129-146
    • Singh, R.1    Barden, A.2    Mori, T.3    Beilin, L.4
  • 38
    • 76449087141 scopus 로고    scopus 로고
    • The effects and mechanism of saponins of Panax notoginseng on glucose metabolism in 3T3-L1 cells
    • Kim JJ, Xiao H, Tan Y, Wang ZZ, Paul Seale J, Qu X. The effects and mechanism of saponins of Panax notoginseng on glucose metabolism in 3T3-L1 cells. Am J Chin Med 2009; 37: 1179-1189.
    • (2009) Am J Chin Med , vol.37 , pp. 1179-1189
    • Kim, J.J.1    Xiao, H.2    Tan, Y.3    Wang, Z.Z.4    Paul Seale, J.5    Qu, X.6
  • 40
    • 0037664875 scopus 로고    scopus 로고
    • Diabetes induced erectile dysfunction and apoptosis in penile crura are recovered by insulin treatment in rats
    • Yamanaka M, Shirai M, Shiina H, Tanaka Y, Tsujimura A, Matsumiya K et al. Diabetes induced erectile dysfunction and apoptosis in penile crura are recovered by insulin treatment in rats. J Urol 2003; 170: 291-297.
    • (2003) J Urol , vol.170 , pp. 291-297
    • Yamanaka, M.1    Shirai, M.2    Shiina, H.3    Tanaka, Y.4    Tsujimura, A.5    Matsumiya, K.6
  • 41
    • 20344396358 scopus 로고    scopus 로고
    • Panax notoginseng saponins preconditioning protects rat liver grafts from ischemia/reperfusion injury via an antiapoptotic pathway
    • Zhang Y, Ye QF, Lu L, Xu XL, Ming YZ, Xiao JS. Panax notoginseng saponins preconditioning protects rat liver grafts from ischemia/reperfusion injury via an antiapoptotic pathway. Hepatobiliary Pancreat Dis Int 2005; 4: 207-212.
    • (2005) Hepatobiliary Pancreat Dis Int , vol.4 , pp. 207-212
    • Zhang, Y.1    Ye, Q.F.2    Lu, L.3    Xu, X.L.4    Ming, Y.Z.5    Xiao, J.S.6
  • 42
    • 79952570374 scopus 로고    scopus 로고
    • Protective effects and mechanism of Panax Notoginseng saponins on oxidative stress-induced damage and apoptosis of rabbit bone marrow stromal cells
    • Qiang H, Zhang C, Shi ZB, Yang HQ, Wang KZ. Protective effects and mechanism of Panax Notoginseng saponins on oxidative stress-induced damage and apoptosis of rabbit bone marrow stromal cells. Chin J Integr Med 2010; 16: 525-530.
    • (2010) Chin J Integr Med , vol.16 , pp. 525-530
    • Qiang, H.1    Zhang, C.2    Shi, Z.B.3    Yang, H.Q.4    Wang, K.Z.5


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