Panax notoginseng saponins preconditioning protects rat liver grafts from ischemia/reperfusion injury via an antiapoptotic pathway

Hepatobiliary and Pancreatic Diseases International

Volumn 4, Issue 2, 2005, Pages 207-212

  Zhang, Yi ^a   Ye, Qi Fa ^b   Lu, Li ^a   Xu, Xian Lin ^a   Ming, Ying Zi ^b   Xiao, Jian Sheng ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b The First People s Hospital of Changde City)   (China)

Author keywords

Apoptosis; Ischemia reperfusion injury; Liver transplantation; Panax notoginseng saponins

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; MESSENGER RNA; PANAX NOTOGINSENG EXTRACT; PROTEIN BCL 2; SAPONIN; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; HISTOPATHOLOGY; LIVER GRAFT; LIVER ISCHEMIA; LIVER PROTECTION; LIVER TRANSPLANTATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGAN DONOR; PROTEIN EXPRESSION; RAT; RAT STRAIN; RECIPIENT; REPERFUSION INJURY;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BASE SEQUENCE; BIOPSY, NEEDLE; DISEASE MODELS, ANIMAL; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOHISTOCHEMISTRY; ISCHEMIC PRECONDITIONING; LIVER FUNCTION TESTS; LIVER TRANSPLANTATION; MALE; MOLECULAR SEQUENCE DATA; PANAX; PROBABILITY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SAPONINS; SENSITIVITY AND SPECIFICITY;

EID: 20344396358     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Ke B, Shen XD, Lassman CR, Gao F, Katori M, Busuttil RW, et al. Interleukin-13 gene transfer protects rat livers from antigen-independent injury induced by ischemia and reperfusion. Transplantation 2003;75:1118-1123.
2. Rudiger HA, Graf R, Clavien PA. Liver ischemia: apoptosis as a central mechanism of injury. J Invest Surg 2003; 16: 149-159.
3. Kamada N, Calne RY. Orthotopic liver transplantation in the rat: Technique using cuff for portal vein anastomosis and biliary drainage. Transplantation 1979;28:47-50.
4. Katori M, Buelow R, Ke B, Ma J, Coito AJ, Iyer S, et al. Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway. Transplantation 2002;73:287-292.
5. Oshiro T, Shiraishi M, Muto Y. Adenovirus mediated gene transfer of antiapoptotic protein in hepatic ischemia-reperfusion injury: the paradoxical effect of Bcl-2 expression in reperfused liver. J Surg Res 2002;103:30-36.
6. Zhang SJ, Zhu CJ, Zhao YF, Li J, Guo WZ. Different ischemic preconditioning for rat liver graft: protection and mechanism. Hepatobiliary Pancreat Dis Int 2003;2:509-512.
7. Ding WX, Yin XM. Dissection of the multiple mechanisms of TNF-α-induced apoptosis in liver injury. J Cell Mol Med 2004; 8:445-454.
8. Yin XM, Ding WX. Death receptor activation-induced hepatocyte apoptosis and liver injury. Curr Mol Med 2003;3:491-508.
9. Kohli V, Selzner M, Madden JF, Bentley RC, Clavien PA. Endothelial cell and hepatocyte deaths occurs by apoptosis; after ischemia-reperfusion injury in the rat liver. Transplantation 1999;67:1099-1105.
10. Wei ZZ, Xia SS. Gamma-hydroxybutyrate protects the liver from warm ischemia-reperfusion injury in rat. Hepatobiliary Pancreat Dis Int 2004;3:245-249.
11. Zhu LQ, Fan JP, Huang QF, Sun SL, Gao Y, Zou YH, et al. Study on the anti-apoptosis induced by hypoxia/hypoglycemia and reoxygenation of panax notoginseng saponins in culture rat hippocampal neurons. Zhongguo Zhong Yao Za Zhi 2003;28:52-55.
12. Ben-Ari Z, Hochhauser E, Burstein I, Papo O, Kaganovsky E, Krasnov T, et al. Role of anti-tumor necrosis factor-α in ischemia/reperfusion injury in isolated rat liver in a blood-free environment. Transplantation 2002;73:1875-1880.
13. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev 2001;15:2922-2933.
14. Gross A, McDonnell JM, Koorsmever SJ. Bcl-2 family members and the mitochondria in apoptosis. Genes Dev 1999;13:1899-1911.
15. Bilbao G, Contreras JL, Eckhoff DE, Mikheeva G, Krasnykh V, Douglas J, et al. Reduction of ischemia-reperfusion injury of the liver by in vivo adenovirus-mediated gene transfer of the anti-apoptotic Bcl-2 gene. Ann Surg 1999;230:185-190.
16. Fumarola C, Cuidotti GG. Stress-induced apoptosis: Toward a symmetry with receptor-mediated cell death. Apoptosis 2004;9:77-82.
17. Xu WH, Ye QF, Xia SS. Apoptosis and proliferation of intrahepatic bile duct after ischemia-reperfusion injury. Hepatobiliary Pancreat Dis Int 2004;3:428-432.
18. Saikumar P, Venkatachalam MA, Role of apoptosis in hypoxic/ischemic damage in the kidney. Semin Nephrol 2003;2:511-521.
19. Cursio R, Gugenheim J, Ricci J, Crenesse D, Rostagno P, Maulon L, et al. Caspase inhibition protects from liver injury following ischemia and reperfusion in rats. Transpl Int 2000;13:S568-S572.
20. Natori S, Selzner M, Valentino CL, Fritz LC, Srinivasan A, Clavien PA, et al. Apoptosis of sinusoidal endothelia cells occurs during liver preservation injury by a caspase-dependent mechanism. Transplantation 1999;68:89-96.
21. Li JW, Zhu PC, Si YC, Xu H, Wu HX. Research on the effects of panax notoginseng saponins on proapoptotic Caspase-3 in the forebrain in the rats with intracerebral hemorrhage. J Beijing Univ Trad Chin Med 2003;26:22-25.