Abundance and diversity of plasmid-associated genes among clinical isolates of Enterococcus faecalis

Plasmid

Volumn 70, Issue 3, 2013, Pages 329-342

  Wardal, Ewa ^a   Gawryszewska, Iwona ^a   Hryniewicz, Waleria ^a   Sadowy, Ewa ^a  

^a NATIONAL MEDICINES INSTITUTE   (Poland)

Author keywords

Asa; Cyl; HiRECC; Par; Rep

Indexed keywords

NUCLEASE S1; PHEROMONE;

ANTIBIOTIC RESISTANCE; ARTICLE; ASA1 GENE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; BEELOCUS GENE; CONTROLLED STUDY; CYLA GENE; ENTEROCOCCUS FAECALIS; GENE SEQUENCE; GENETIC VARIABILITY; MICROBIOME; NONHUMAN; NUCLEOTIDE SEQUENCE; OMEGA EPSILON ZETA GENE; PAR GENE; PLASMID; PLASMID CONTENT; POLYMERASE CHAIN REACTION; PULSED FIELD GEL ELECTROPHORESIS; REP10PIM13 GENE; REP13PC194 GENE; REP1PIP501 GENE; REP2PRE25 GENE; REP4PMBB1 GENE; REP6PS86 GENE; REP7PT181 GENE; REP8PAM373 GENE; REP9PAD1/PTEF2/PCF10 GENE; UNINDEXED SEQUENCE;

ENTEROCOCCUS FAECALIS;

ASA; CYL; HIRECC; PAR; REP;

BACTERIAL PROTEINS; DEOXYRIBONUCLEASES; DNA TRANSPOSABLE ELEMENTS; ELECTROPHORESIS, GEL, PULSED-FIELD; ENTEROCOCCUS FAECALIS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; GENETIC VARIATION; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; PHEROMONES; PHYLOGENY; PLASMIDS; SEQUENCE ANALYSIS, DNA;

EID: 84887621731     PISSN: 0147619X     EISSN: 10959890     Source Type: Journal    
DOI: 10.1016/j.plasmid.2013.07.003     Document Type: Article

References (47)

1. Arias C.A., Murray B.E. The rise of the Enterococcus: beyond vancomycin resistance. Nat. Rev. Microbiol. 2012, 10:266-278.
2. Barton B.M., Harding G.P., Zuccarelli A.J. A general method for detecting and sizing large plasmids. Anal. Biochem. 1995, 226:235-240.
3. Coburn P.S., Baghdayan A.S., Craig N., Burroughs A., Tendolkar P., Miller K., Najar F.Z., Roe B.A., Shankar N. A novel conjugative plasmid from Enterococcus faecalis E99 enhances resistance to ultraviolet radiation. Plasmid 2010, 64:18-25.
4. Coque T.M. Evolutionary biology of pathogenic enterococci. Evolutionary Biology of Bacterial and Fungal Pathogens 2008, 501-523. ASM Press, Washington, DC. F. Baquero, C. Nombela, G.H. Cassell, J.A. Gutierrez (Eds.).
5. De Boever E.H., Clewell D.B., Fraser C.M. Enterococcus faecalis conjugative plasmid pAM373: complete nucleotide sequence and genetic analyses of sex pheromone response. Mol. Microbiol. 2000, 37:1327-1341.
6. de Lencastre H., Severina E.P., Roberts R.B., Kreiswirth B.N., Tomasz A. Testing the efficacy of a molecular surveillance network: methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF) genotypes in six hospitals in the metropolitan New York City area. The BARG initiative pilot study group. Bacterial antibiotic resistance group. Microb. Drug. Resist. 1996, 2:343-351.
7. Dunny G.M., Brown B.L., Clewell D.B. Induced cell aggregation and mating in Streptococcus faecalis: evidence for a bacterial sex pheromone. Proc. Natl. Acad. Sci. USA 1978, 75:3479-3483.
8. Freitas, A.R., Ruiz-Garbajosa, P., Francia, M.V., Novais, C., Zervos, M.J., Donabedian, S., Peixe, L., Baquero, F., Coque, T.M., 2011. Spread of vancomycin-resistant among Enterococcus faecalis: the influence of pAD1 and Inc18-plasmids (1987-2005). 21th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). Milan, Italy.
9. Galli D., Lottspeich F., Wirth R. Sequence analysis of Enterococcus faecalis aggregation substance encoded by the sex pheromone plasmid pAD1. Mol. Microbiol. 1990, 4:895-904.
10. Hancock L.E., Gilmore M.S. Pathogenicity of enterococci. Gram-Positive Pathogens 2000, 251-258. ASM Press, Washington, DC. V.A. Fischetti, R.P. Novick, J.J. Ferretti, D.A. Portnoy, J.I. Rood (Eds.).
11. Handwerger S., Skoble J., Discotto L.F., Pucci M.J. Heterogeneity of the vanA gene cluster in clinical isolates of enterococci from the northeastern United States. Antimicrob. Agents Chemother. 1995, 39:362-368.
12. Hegstad K., Mikalsen T., Coque T.M., Werner G., Sundsfjord A. Mobile genetic elements and their contribution to the emergence of antimicrobial resistant Enterococcus faecalis and Enterococcus faecium. Clin. Microbiol. Infect. 2010, 16:541-554.
13. Hendrickx A.P., van Luit-Asbroek M., Schapendonk C.M., van Wamel W.J., Braat J.C., Wijnands L.M., Bonten M.J., Willems R.J. SgrA, a nidogen-binding LPXTG surface adhesin implicated in biofilm formation, and EcbA, a collagen binding MSCRAMM, are two novel adhesins of hospital-acquired Enterococcus faecium. Infect. Immun. 2009, 77:5097-5106.
14. Hirt H., Wirth R., Muscholl A. Comparative analysis of 18 sex pheromone plasmids from Enterococcus faecalis: detection of a new insertion element on pPD1 and implications for the evolution of this plasmid family. Mol. Gen. Genet. 1996, 252:640-647.
15. Ike Y., Clewell D.B. Genetic analysis of the pAD1 pheromone response in Streptococcus faecalis, using transposon Tn917 as an insertional mutagen. J. Bacteriol. 1984, 158:777-783.
16. Jensen L.B., Garcia-Migura L., Valenzuela A.J., Løhr M., Hasman H., Aarestrup F.M. A classification system for plasmids from enterococci and other Gram-positive bacteria. J. Microbiol. Methods 2010, 80:25-43.
17. Kao S.M., Olmsted S.B., Viksnins A.S., Gallo J.C., Dunny G.M. Molecular and genetic analysis of a region of plasmid pCF10 containing positive control genes and structural genes encoding surface proteins involved in pheromone-inducible conjugation in Enterococcus faecalis. J. Bacteriol. 1991, 173:7650-7664.
18. Kawalec M., Pietras Z., Daniłowicz E., Jakubczak A., Gniadkowski M., Hryniewicz W., Willems R.J. Clonal structure of Enterococcus faecalis isolated from Polish hospitals: characterization of epidemic clones. J. Clin. Microbiol. 2007, 45:147-153.
19. Khan S.A. Rolling-circle replication of bacterial plasmids. Microbiol. Mol. Biol. Rev. 1997, 61:442-455.
20. Lányí B Classical and rapid identification methods for medically important bacteria. Method Microbiol. 1987, 19:1-67.
21. Laverde Gomez J.A., van Schaik W., Freitas A.R., Coque T.M., Weaver K.E., Francia M.V., Witte W., Werner G. A multiresistance megaplasmid pLG1 bearing a hylEfm genomic island in hospital Enterococcus faecium isolates. Int. J. Med. Microbiol. 2011, 301:165-175.
22. Leavis H.L., Bonten M.J., Willems R.J. Identification of high-risk enterococcal clonal complexes: global dispersion and antibiotic resistance. Curr. Opin. Microbiol. 2006, 9:454-460.
23. León-Sampedro, R., Tedim, A.P., del Campo, R., Rodríguez, M.C., Francia, M.V., Willems, R.W., Baquero, F., Coque, T.M., 2012. Clonal and plasmid diversity among Enterococcus faecalis from wild and migratory birds. In: International Plasmid Biology Conference, 2012. Santander, Spain.
24. Martínez-Bueno M., Valdivia E., Gálvez A., Maqueda M. pS86, a new theta-replicating plasmid from Enterococcus faecalis. Curr. Microbiol. 2000, 41:257-261.
25. McBride S.M., Fischetti V.A., Leblanc D.J., Moellering R.C., Gilmore M.S. Genetic diversity among Enterococcus faecalis. PLoS One 2007, 2:e582.
26. Moellering R.C. Emergence of Enterococcus as a significant pathogen. Clin. Infect. Dis. 1992, 14:1173-1176.
27. Moritz E.M., Hergenrother P.J. Toxin-antitoxin systems are ubiquitous and plasmid-encoded in vancomycin-resistant enterococci. Proc. Natl. Acad. Sci. USA 2007, 104:311-316.
28. Nallapareddy S.R., Sillanpää J., Mitchell J., Singh K.V., Chowdhury S.A., Weinstock G.M., Sullam P.M., Murray B.E. Conservation of Ebp-type pilus genes among enterococci and demonstration of their role in adherence of Enterococcus faecalis to human platelets. Infect. Immun. 2011, 79:2911-2920.
29. Paulsen I.T., Banerjei L., Myers G.S., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L., Brinkac L., Beanan M., Daugherty S., DeBoy R.T., Durkin S., Kolonay J., Madupu R., Nelson W., Vamathevan J., Tran B., Upton J., Hansen T., Shetty J., Khouri H., Utterback T., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M. Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science 2003, 299:2071-2074.
30. Rosvoll T.C., Pedersen T., Sletvold H., Johnsen P.J., Sollid J.E., Simonsen G.S., Jensen L.B., Nielsen K.M., Sundsfjord A. PCR-based plasmid typing in Enterococcus faecium strains reveals widely distributed pRE25-, pRUM-, pIP501- and pHTbeta-related replicons associated with glycopeptide resistance and stabilizing toxin-antitoxin systems. FEMS Immunol. Med. Microbiol. 2010, 58:254-268.
31. Rosvoll T.C., Lindstad B.L., Lunde T.M., Hegstad K., Aasnaes B., Hammerum A.M., Lester C.H., Simonsen G.S., Sundsfjord A., Pedersen T. Increased high-level gentamicin resistance in invasive Enterococcus faecium is associated with aac(6')Ie-aph(2″)Ia-encoding transferable megaplasmids hosted by major hospital-adapted lineages. FEMS Immunol. Med. Microbiol. 2012, 66:166-176.
32. Ruiz-Garbajosa P., Bonten M.J., Robinson D.A., et al. Multilocus sequence typing scheme for Enterococcus faecalis reveals hospital-adapted genetic complexes in a background of high rates of recombination. J. Clin. Microbiol. 2006, 44:2220-2228.
33. Sadowy E., Sieńko A., Hryniewicz W. Comparison of multilocus variable-number tandem-repeat analysis with multilocus sequence typing and pulsed-field gel electrophoresis for Enterococcus faecalis. Pol. J. Microbiol. 2011, 60:335-339.
34. Sánchez-Hidalgo M., Maqueda M., Gálvez A., Abriouel H., Valdivia E., Martínez-Bueno M. The genes coding for enterocin EJ97 production by Enterococcus faecalis EJ97 are located on a conjugative plasmid. Appl. Environ. Microbiol. 2003, 69:1633-1641.
35. Schwarz F.V., Perreten V., Teuber M. Sequence of the 50-kb conjugative multiresistance plasmid pRE25 from Enterococcus faecalis RE25. Plasmid 2001, 46:170-187.
36. Semedo T., Santos M.A., Martins P., Silva Lopes M.F., Marques J.J.F., Tenreiro R., Crespo M.T.B. Comparative study using type strains and clinical and food isolates to examine hemolytic activity and occurrence of the cyl operon in Enterococci. J. Clin. Microbiol. 2003, 41. 2569-2476.
37. Song X., Sun J., Mikalsen T., Roberts A.P., Sundsfjord A. Characterisation of the plasmidome within Enterococcus faecalis isolated from marginal periodontitis patients in Norway. PLoS One 2013, 8:e62248.
38. Strzelecki J., Hryniewicz W., Sadowy E. Gelatinase-associated phenotypes and genotypes among clinical isolates of Enterococcus faecalis in Poland. Pol. J. Microbiol. 2011, 60:287-292.
39. Tamura K., Peterson D., Peterson N., Stecher G., Nei M., Kumar S. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol. Biol. Evol. 2011, 28:2731-2739.
40. Tedim, A.P., Miranda, A.C., Ruiz-Garbajosa, P., Freitas, A.R., Francia, M.V., Baquero, F., Coque, T.M., 2011. Molecular characterisation of Enterococcus faecalis plasmids from clinical isolates in Spain, 2001-2009. 21th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). Milan, Italy.
41. Tendolkar P.M., Baghdayan A.S., Shankar N. Putative surface proteins encoded within a novel transferable locus confer a high-biofilm phenotype to Enterococcus faecalis. J. Bacteriol. 2006, 188:2063-2072.
42. Vanek N.N., Simon S.I., Jacques-Palaz K., Mariscalco M.M., Dunny G.M., Rakita R.M. Enterococcus faecalis aggregation substance promotes opsonin-independent binding to human neutrophils via a complement receptor type 3-mediated mechanism. FEMS Immunol. Med. Microbiol. 1999, 26:49-60.
43. Vankerckhoven V., Van Autgaerden T., Vael C., Lammens C., Chapelle S., Rossi R., Jabes D., Goossens H. Development of a multiplex PCR for the detection of asa1, gelE, cylA, esp, and hyl genes in enterococci and survey for virulence determinants among European hospital isolates of Enterococcus faecium. J. Clin. Microbiol. 2004, 42:4473-4479.
44. Wardal E., Sadowy E., Hryniewicz W. Complex nature of enterococcal pheromone-responsive plasmids. Pol. J. Microbiol. 2010, 59:79-87.
45. Weaver K.E., Tritle D.J. Identification and characterization of an Enterococcus faecalis plasmid pAD1-encoded stability determinant which produces two small RNA molecules necessary for its function. Plasmid 1994, 32:168-181.
46. Weaver K.E., Rice L.B., Churchward G. Plasmids and transposons. The Enterococci: Pathogenesis, Molecular Biology and Antibiotic Resistance 2002, 219-265. ASM Press, Washington, DC. M.S. Gilmore (Ed.).
47. Weaver K.E., Kwong S.M., Firth N., Francia M.V. The RepA_N replicons of Gram-positive bacteria: a family of broadly distributed but narrow host range plasmids. Plasmid 2009, 61:94-109.