Pkd1 is required for male reproductive tract development

Mechanisms of Development

Volumn 130, Issue 11-12, 2013, Pages 567-576

  Nie, Xuguang ^a   Arend, Lois J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Efferent duct; Epididymis; Mice; Polycystic kidney disease; Polycystin 1

Indexed keywords

BONE MORPHOGENETIC PROTEIN; POLYCYSTIN 1; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR PAX2; TRANSFORMING GROWTH FACTOR; TUBULIN;

ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; CELL DEDIFFERENTIATION; CELL PROLIFERATION; CYTOSKELETON; EPIDIDYMIS; EPIDIDYMIS DISEASE; GENE MUTATION; INCIDENCE; KIDNEY POLYCYSTIC DISEASE; MALE; MALE GENITAL SYSTEM; MALE INFERTILITY; MESONEPHROS; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

MURINAE; MUS;

ADPKD; AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE; EFFERENT DUCT; EPIDIDYMIS; IG; IMMUNOGLOBULIN; MICE; PC1; PKD; POLYCYSTIC KIDNEY DISEASE; POLYCYSTIN-1; POLYCYSTIN1;

ANIMALS; BODY PATTERNING; CYTOSKELETON; EMBRYO, MAMMALIAN; EPIDIDYMIS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INFERTILITY, MALE; INTEGRASES; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PAX2 TRANSCRIPTION FACTOR; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TRPP CATION CHANNELS; TUBULIN; UROTHELIUM; WOLFFIAN DUCTS;

EID: 84887610145     PISSN: 09254773     EISSN: 18726356     Source Type: Journal    
DOI: 10.1016/j.mod.2013.07.006     Document Type: Article

References (47)

1. Airik R., Bussen M., Singh M.K., Petry M., Kispert A. Tbx18 regulates the development of the ureteral mesenchyme. J. Clin. Invest. 2006, 116:663-674.
2. Belet U., Danaci M., Sarikaya S., Odabas F., Utas C., Tokgoz B., Sezer T., Turgut T., Erdogan N., Akpolat T. Prevalence of epididymal, seminal vesicle, prostate, and testicular cysts in autosomal dominant polycystic kidney disease. Urology 2002, 60:138-141.
3. Bhunia A.K., Piontek K., Boletta A., Liu L., Qian F., Xu P.N., Germino F.J., Germino G.G. PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 2002, 109:157-168.
4. Boca M., D'Amato L., Distefano G., Polishchuk R.S., Germino G.G., Boletta A. Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion. Mol. Biol. Cell 2007, 18:4050-4061.
5. Calvet J.P. Polycystic kidney disease: primary extracellular matrix abnormality or defective cellular differentiation?. Kidney Int. 1993, 43:101-108.
6. Chapin H.C., Caplan M.J. The cell biology of polycystic kidney disease. J. Cell Biol. 2010, 191:701-710.
7. Chapman A.B. Autosomal dominant polycystic kidney disease: time for a change?. J. Am. Soc. Nephrol.: JASN 2007, 18:1399-1407.
8. Chauvet V., Qian F., Boute N., Cai Y., Phakdeekitacharoen B., Onuchic L.F., Attie-Bitach T., Guicharnaud L., Devuyst O., Germino G.G., Gubler M.C. Expression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney development. Am. J. Pathol. 2002, 160:973-983.
9. Cooke P.S., Young P., Cunha G.R. Androgen receptor expression in developing male reproductive organs. Endocrinology 1991, 128:2867-2873.
10. Cornwall G.A. New insights into epididymal biology and function. Hum. Reprod. Update 2009, 15:213-227.
11. Delmas P., Nomura H., Li X., Lakkis M., Luo Y., Segal Y., Fernandez-Fernandez J.M., Harris P., Frischauf A.M., Brown D.A., Zhou J. Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. J. Biol. Chem. 2002, 277:11276-11283.
12. Di Giovanni V., Alday A., Chi L., Mishina Y., Rosenblum N.D. Alk3 controls nephron number and androgen production via lineage-specific effects in intermediate mesoderm. Development 2011, 138:2717-2727.
13. Drummond I.A. Polycystins, focal adhesions and extracellular matrix interactions. Biochim. Biophys. Acta 2011, 1812:1322-1326.
14. Grantham J.J., Mulamalla S., Swenson-Fields K.I. Why kidneys fail in autosomal dominant polycystic kidney disease. Nat. Rev. Nephrol. 2011, 7:556-566.
15. Guay-Woodford L.M. Murine models of polycystic kidney disease: molecular and therapeutic insights. Am. J. Physiol. Renal Physiol. 2003, 285:F1034-49.
16. Hannema S.E., Hughes I.A. Regulation of Wolffian duct development. Horm. Res. 2007, 67:142-151.
17. Hinton B.T., Galdamez M.M., Sutherland A., Bomgardner D., Xu B., Abdel-Fattah R., Yang L. How do you get six meters of epididymis inside a human scrotum?. J. Androl. 2011, 32:558-564.
18. Hsia N., Cornwall G.A. DNA microarray analysis of region-specific gene expression in the mouse epididymis. Biol. Reprod. 2004, 70:448-457.
19. Joseph A., Yao H., Hinton B.T. Development and morphogenesis of the Wolffian/epididymal duct, more twists and turns. Dev. Biol. 2009, 325:6-14.
20. Kanagarajah P., Ayyathurai R., Lynne C.M. Male infertility and adult polycystic kidney disease revisited: case report and current literature review. Andrologia 2012, 44(Suppl. 1):838-841.
21. Kitagaki J., Ueda Y., Chi X., Sharma N., Elder C.M., Truffer E., Costantini F., Lewandoski M., Perantoni A.O. FGF8 is essential for formation of the ductal system in the male reproductive tract. Development 2011, 138:5369-5378.
22. Klattig J., Englert C. The Mullerian duct: recent insights into its development and regression. Sex. Dev. genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2007, 1:271-278.
23. Manno M., Marchesan E., Tomei F., Cicutto D., Maruzzi D., Maieron A., Turco A. Polycystic kidney disease and infertility: case report and literature review. Archivio italiano di urologia, andrologia: organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica/Associazione ricerche in, urologia 2005, 77:25-28.
24. Nie X., Xu J., El-Hashash A., Xu P.X. Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev. Biol. 2011, 352:141-151.
25. Nishio S., Hatano M., Nagata M., Horie S., Koike T., Tokuhisa T., Mochizuki T. Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation. J. Clin. Invest. 2005, 115:910-918.
26. Ohyama T., Groves A.K. Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome. Genesis 2004, 38:195-199.
27. Orvis G.D., Behringer R.R. Cellular mechanisms of Mullerian duct formation in the mouse. Dev. Biol. 2007, 306:493-504.
28. Piontek K.B., Huso D.L., Grinberg A., Liu L., Bedja D., Zhao H., Gabrielson K., Qian F., Mei C., Westphal H., Germino G.G. A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J. Am. Soc. Nephrol. JASN 2004, 15:3035-3043.
29. Qian F., Germino F.J., Cai Y., Zhang X., Somlo S., Germino G.G. PKD1 interacts with PKD2 through a probable coiled-coil domain. Nat. Genet. 1997, 16:179-183.
30. Sakurai H. Molecular mechanism of ureteric bud development. Semin. Cell Dev. Biol. 2003, 14:217-224.
31. Sandford R., Sgotto B., Aparicio S., Brenner S., Vaudin M., Wilson R.K., Chissoe S., Pepin K., Bateman A., Chothia C., Hughes J., Harris P. Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains. Hum. Mol. Genet. 1997, 6:1483-1489.
32. Shannon M.B., Patton B.L., Harvey S.J., Miner J.H. A hypomorphic mutation in the mouse laminin alpha5 gene causes polycystic kidney disease. J. Am. Soc. Nephrol. JASN 2006, 17:1913-1922.
33. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 1999, 21:70-71.
34. Staack A., Donjacour A.A., Brody J., Cunha G.R., Carroll P. Mouse urogenital development: a practical approach. Differ. Res. Biol. Diversity 2003, 71:402-413.
35. Sullivan L.P., Grantham J.J. Mechanisms of fluid secretion by polycystic epithelia. Kidney Int. 1996, 49:1586-1591.
36. Sullivan L.P., Wallace D.P., Grantham J.J. Epithelial transport in polycystic kidney disease. Physiol. Rev. 1998, 78:1165-1191.
37. Tomaszewski J., Joseph A., Archambeault D., Yao H.H. Essential roles of inhibin beta A in mouse epididymal coiling. Proc. Natl. Acad. Sci. USA 2007, 104:11322-11327.
38. Torra R., Sarquella J., Calabia J., Marti J., Ars E., Fernandez-Llama P., Ballarin J. Prevalence of cysts in seminal tract and abnormal semen parameters in patients with autosomal dominant polycystic kidney disease. Clin. J. Am. Soc. Nephrol. CJASN 2008, 3:790-793.
39. Vora N., Perrone R., Bianchi D.W. Reproductive issues for adults with autosomal dominant polycystic kidney disease. Am. J. Kidney Dis. the Official Journal of the National Kidney Foundation 2008, 51:307-318.
40. Wilhelm D., Koopman P. The makings of maleness: towards an integrated view of male sexual development. Nat. Rev. Genet. 2006, 7:620-631.
41. Wilson P.D. Polycystin: new aspects of structure, function, and regulation. J. Am. Soc. Nephrol. JASN 2001, 12:834-845.
42. Wilson P.D. Polycystic kidney disease. N. Engl. J. Med. 2004, 350:151-164.
43. Wilson P.D. Mouse models of polycystic kidney disease. Curr. Top. Dev. Biol. 2008, 84:311-350.
44. Xu B., Abdel-Fattah R., Yang L., Crenshaw S.A., Black M.B., Hinton B.T. Testicular lumicrine factors regulate ERK, STAT, and NFKB pathways in the initial segment of the rat epididymis to prevent apoptosis. Biol. Reprod. 2011, 84:1282-1291.
45. Xu B., Yang L., Lye R.J., Hinton B.T. P-MAPK1/3 and DUSP6 regulate epididymal cell proliferation and survival in a region-specific manner in mice. Biol. Reprod. 2010, 83:807-817.
46. Xu G.M., Gonzalez-Perrett S., Essafi M., Timpanaro G.A., Montalbetti N., Arnaout M.A., Cantiello H.F. Polycystin-1 activates and stabilizes the polycystin-2 channel. J. Biol. Chem. 2003, 278:1457-1462.
47. Xu G.M., Sikaneta T., Sullivan B.M., Zhang Q., Andreucci M., Stehle T., Drummond I., Arnaout M.A. Polycystin-1 interacts with intermediate filaments. J. Biol. Chem. 2001, 276:46544-46552.