Clot composition and treatment approach to acute ischemic stroke: The road so far

Annals of Indian Academy of Neurology

Volumn 16, Issue 4, 2013, Pages 494-497

  Singh, Paramdeep ^a   Kaur, Rupinderjeet ^a   Kaur, Amarpreet ^a  

^a GGS Medical College & Hospital Faridkot   (India)

Author keywords

Clot composition; histopathology; stroke; thrombus

Indexed keywords

ALTEPLASE; FIBRIN;

ANGIOGRAPHY; BLOOD CLOT; BLOOD CLOT LYSIS; BRAIN ISCHEMIA; CAROTID ARTERY; DRUG RESPONSE; ERYTHROCYTE; HISTOLOGY; HISTOPATHOLOGY; HUMAN; MECHANICAL THROMBECTOMY; MICROSCOPY; MIDDLE CEREBRAL ARTERY; MULTIDETECTOR COMPUTED TOMOGRAPHY; NEUTROPHIL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; REVIEW; SCANNING ELECTRON MICROSCOPY; THROMBOEMBOLISM; THROMBUS;

EID: 84887577123     PISSN: 09722327     EISSN: 19983549     Source Type: Journal    
DOI: 10.4103/0972-2327.120433     Document Type: Review

References (29)

1. Torvik A, Joergensen L. Thrombotic and embolic occlusions of the carotid arteries in an autopsy material. i. prevalence, location and associated diseases. J. Neurol Sci 1964;41:24-39.
2. Minnerup J, Kleinschnitz C. Visualization of clot composition in ischemic stroke: Do we get what we see? Stroke 2011;42:1193-4.
3. Marder VJ, Chute DJ, Starkman S, Abolian AM, Kidwell C, Liebeskind D, et al. Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke. Stroke 2006;37:2086-93.
4. Liebeskind DS, Sanossian N, Yong WH, Starkman S, Tsang MP, Moya AL, et al. CT and MRI early vessel signs reflect clot composition in acute stroke. Stroke 2011;42:1237-43.
5. Jang IK, Gold HK, Ziskind AA, Fallon JT, Holt RE, Leinbach RC, et al. Differential sensitivity of erythrocyte-rich and platelet-rich arterial thrombi to lysis with recombinant tissue-Type plasminogen activator. A possible explanation for resistance to coronary thrombolysis. Circulation 1989;79:920-8.
6. Kirchhof K, Sikinger M, Welzel T, Zoubaa S, Sartor K. Does the result of thrombolysis with recombinant tissue-Type plasminogen activator (rt-PA) in rabbits depend on the erythrocyte-.and fibrin-content of a thrombus? Rofo 2004;176:98-105.
7. Kimura K, Iguchi Y, Shibazaki K, Terasawa Y, Aoki J, Matsumoto N. The presence of a right-To-left shunt is associated with dramatic improvement after thrombolytic therapy in patients with acute ischemic stroke. Stroke 2009;40:303-5.
8. Almekhlafi MA, Hu WY, Hill MD, Auer RN. Calcification and endothelialization of thrombi in acute stroke. Ann Neurol 2008;64:344-8.
9. Nogueira RG, Sukavaneshvar S, Rabinov JD, Dabus G, Yoo AJ, Buonanno FS, et al. Scanning electron microscopy analysis of thromboembolic material retrieved from cerebral and cervical arteries of patients with acute ischemic stroke: Abstracts from the 2008 international stroke conference. Stroke 2008;39:562.
10. Mehta BP, Nogueira RG. Should clot composition affect choice of endovascular therapy? Neurology 2012;79:S63-7.
11. Flacke S, Fischer S, Scott MJ, Fuhrhop RJ, Allen JS, McLean M, et al. Novel MRI contrast agent for molecular imaging of fibrin: Implications for detecting vulnerable plaques. Circulation 2001;104:1280-5.
12. von zur Muhlen C, von Elverfeldt D, Moeller JA, Choudhury RP, Paul D, Hagemeyer CE, et al. Magnetic resonance imaging contrast agent targeted toward activated platelets allows in vivo detection of thrombosis and monitoring of thrombolysis. Circulation 2008;118:258-67.
13. Overoye-Chan K, Koerner S, Looby RJ, Kolodziej AF, Zech SG, Deng Q, et al. EP-2104R: A fibrin-specific gadolinium-Based MRI contrast agent for detection of thrombus. J. Am Chem Soc 2008;130:6025-39.
14. Botnar RM, Perez AS, Witte S, Wiethoff AJ, Laredo J, Hamilton J, et al. In vivo molecular imaging of acute and subacute thrombosis using a fibrin-binding magnetic resonance imaging contrast agent. Circulation 2004;109:2023-9.
15. Spuentrup E, Fausten B, Kinzel S, Wiethoff AJ, Botnar RM, Graham PB, et al. Molecular magnetic resonance imaging of atrial clots in a swine model. Circulation 2005;112:396-9.
16. Sirol M, Fuster V, Badimon JJ, Fallon JT, Moreno PR, Toussaint JF, et al. Chronic thrombus detection with in vivo magnetic resonance imaging and a fibrin-Targeted contrast agent. Circulation 2005;112:1594-600.
17. Mitsumori LM, Hatsukami TS, Ferguson MS, Kerwin WS, Cai J, Yuan C. In vivo accuracy of multisequence MR imaging for identifying unstable fibrous caps in advanced human carotid plaques. J. Magn Reson Imaging 2003;17:410-20.
18. Hatsukami TS, Ross R, Polissar NL, Yuan C. Visualization of fibrous cap thickness and rupture in human atherosclerotic carotid plaque in vivo with high-resolution magnetic resonance imaging. Circulation 2000;102:959-64.
19. Yuan C, Zhang SX, Polissar NL, Echelard D, Ortiz G, Davis JW, et al. Identification of fibrous cap rupture with magnetic resonance imaging is highly associated with recent transient ischemic attack or stroke. Circulation 2002;105:181-5.
20. Saba L, Caddeo G, Sanfilippo R, Montisci R, Mallarini G. CT and ultrasound in the study of ulcerated carotid plaque compared with surgical results: Potentialities and advantages of multidetector row CT angiography. AJNR Am J. Neuroradiol 2007;28:1061-6.
21. Hardie AD, Kramer CM, Raghavan P, Baskurt E, Nandalur KR. The impact of expansive arterial remodeling on clinical presentation in carotid artery disease: A multidetector CT angiography study. AJNR Am J. Neuroradiol 2007;28:1067-70.
22. Rothwell PM, Gibson R, Warlow CP. Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischemic stroke in patients with symptomatic carotid stenosis. On behalf of the European Carotid Surgery Trialists' Collaborative Group. Stroke 2000;31:615-21.
23. Eliasziw M, Streifler JY, Fox AJ, Hachinski VC, Ferguson GG, Barnett HJ. Significance of plaque ulceration in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial. Stroke 1994;25:304-8.
24. Bassiouny HS, Sakaguchi Y, Mikucki SA, McKinsey JF, Piano G, Gewertz BL, et al. Juxtalumenal location of plaque necrosis and neoformation in symptomatic carotid stenosis. J. Vasc Surg 1997;26:585-94.
25. Figueroa AL, Subramanian SS, Cury RC, Truong QA, Gardecki JA, Tearney GJ, et al. Distribution of inflammation within carotid atherosclerotic plaques with high-risk morphological features: A comparison between positron emission tomography activity, plaque morphology, and histopathology. Circ Cardiovasc Imaging 2012;5:69-77.
26. Graebe M, Pedersen SF, Højgaard L, Kjaer A, Sillesen H. 18FDG PET and ultrasound echolucency in carotid artery plaques. JACC Cardiovasc Imaging 2010;3:289-95.
27. Silvera SS, Aidi HE, Rudd JH, Mani V, Yang L, Farkouh M, et al. Multimodality imaging of atherosclerotic plaque activity and composition using FDG-PET/CT and MRI in carotid and femoral arteries. Atherosclerosis 2009;207:139-43.
28. Spuentrup E, Botnar RM, Wiethoff AJ, Ibrahim T, Kelle S, Katoh M, et al. MR imaging of thrombi using EP-2104R, a fibrin-specific contrast agent: Initial results in patients. Eur Radiol 2008;18:1995-2005.
29. Uppal R, Catana C, Ay I, Benner T, Sorensen AG, Caravan P. Bimodal thrombus imaging: Simultaneous PET/MR imaging with a fibrin-Targeted dual PET/MR probe: Feasibility study in rat model. Radiology 2011;258:812-20.